Pabpc1 MGI Mouse Gene Detail - MGI:1349722 - poly(A) binding protein, cytoplasmic 1

Symbol

Pabpc1
Name

poly(A) binding protein, cytoplasmic 1
Synonyms

Pabp1, Pabpl1

Feature Type

protein coding gene
IDs

MGI:1349722
NCBI Gene: 18458
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr15:36595902-36609825 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 14.51 cM, cytoband C
Mapping Data

2 experiments

SNPs within 2kb

325 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349722	protein coding gene	Chr15:36595902-36609912 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021796	protein coding gene	Chr15:34984273-35001023 (-)
A/J	MGP_AJ_G0021757	protein coding gene	Chr15:33688735-33704774 (-)
AKR/J	MGP_AKRJ_G0021736	protein coding gene	Chr15:34620133-34633233 (-)
BALB/cJ	MGP_BALBcJ_G0021764	protein coding gene	Chr15:33692792-33705771 (-)
C3H/HeJ	MGP_C3HHeJ_G0021538	protein coding gene	Chr15:34584581-34599093 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022203	protein coding gene	Chr15:36327411-36340817 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019740	protein coding gene	Chr15:31495434-31510120 (-)
CAST/EiJ	MGP_CASTEiJ_G0021054	protein coding gene	Chr15:34979757-34996277 (-)
CBA/J	MGP_CBAJ_G0021507	protein coding gene	Chr15:37498430-37514897 (-)
DBA/2J	MGP_DBA2J_G0021631	protein coding gene	Chr15:33502066-33515261 (-)
FVB/NJ	MGP_FVBNJ_G0021609	protein coding gene	Chr15:32905818-32919564 (-)
LP/J	MGP_LPJ_G0021700	protein coding gene	Chr15:34903403-34916582 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021633	protein coding gene	Chr15:40597227-40611568 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022226	protein coding gene	Chr15:34765854-34779137 (-)
PWK/PhJ	MGP_PWKPhJ_G0020798	protein coding gene	Chr15:33531587-33545716 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020636	protein coding gene	Chr15:34470636-34483540 (-)
WSB/EiJ	MGP_WSBEiJ_G0021110	protein coding gene	Chr15:34741649-34758164 (-)

Human Ortholog

PABPC1, poly(A) binding protein cytoplasmic 1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PABPC1, poly(A) binding protein cytoplasmic 1
Synonyms

PAB1, PABP, PABP1, PABPC2, PABPL1
Links

HGNC:8554

NCBI Gene ID: 26986

neXtProt AC: NX_P11940

UniProt: P11940
Chr Location

8q22.3; chr8:100685816-100722809 (-) GRCh38

Human Ortholog

PABPC3, poly(A) binding protein cytoplasmic 3
Synonyms

PABP3, PABPL3, tPABP
Links

HGNC:8556

NCBI Gene ID: 5042

neXtProt AC: NX_Q9H361

UniProt: Q9H361
Chr Location

13q12.13; chr13:25096136-25099254 (+) GRCh38

MGI Vertebrate Homology

Pabpc1 stringent orthology
2 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PABPC1, PABPC3
Gene Tree

Pabpc1

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Phenotype Summary

17 phenotype references

All Mutations and Alleles

34
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

26
Targeted

4
Genomic Mutations

2 involving Pabpc1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available

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All GO Annotations

52
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

58
cDNA Data

1108
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PABPC1

Xenbase pabpc1

ZFIN pabpc1a

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All Sequences

75
RefSeq

4
UniProt

8
CCDS

CCDS27431.1

Ensembl

ENSMUSG00000022283 (Evidence)
NCBI Gene

18458

			Length	Strain/Species	Flank
genomic	18458	NCBI Gene Model \| MGI Sequence Detail	13924	C57BL/6J	± kb
transcript	NM_008774	RefSeq \| MGI Sequence Detail	2842	C57BL/6
polypeptide	P29341	UniProt \| EBI \| MGI Sequence Detail	636	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000012204 polyadenylate-binding protein 1

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR036053 PABC (PABP) domain

IPR034364 PABP, RNA recognition motif 1

IPR045305 PABP, RNA recognition motif 2

IPR006515 Polyadenylate binding protein, human types 1, 2, 3, 4

IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR003954 RNA recognition motif domain, eukaryote
GlyGen

P29341 5 sites, 1 O-linked glycan (5 sites)

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All nucleic 1114

cDNA 1108

Primer pair 5

Other 1

Microarray probesets 4

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MGD-MRK-13120, MGD-MRK-27031, MGI:104668

Summaries

All 86

Developmental Gene Expression 12

Gene Ontology 17

Phenotypes 17
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:349174 Herron RS, et al., A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway. Elife. 2023 Sep 4;12

TSS for Pabpc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134043	Chr15:36609812-36609864 (-)	-13 bp
Tssr134042	Chr15:36609784-36609810 (-)	28 bp
Tssr134041	Chr15:36609755-36609772 (-)	61 bp
Tssr134040	Chr15:36609378-36609383 (-)	444 bp
Tssr134039	Chr15:36609203-36609227 (-)	610 bp
Tssr134038	Chr15:36609070-36609084 (-)	748 bp
Tssr134037	Chr15:36609038-36609046 (-)	783 bp
Tssr134036	Chr15:36608989-36609016 (-)	822 bp
Tssr134035	Chr15:36608936-36608964 (-)	875 bp
Tssr134034	Chr15:36608894-36608905 (-)	925 bp
Tssr134033	Chr15:36608868-36608879 (-)	951 bp
Tssr134032	Chr15:36608865-36608866 (-)	959 bp
Tssr134031	Chr15:36608795-36608863 (-)	996 bp
Tssr134030	Chr15:36608728-36608757 (-)	1,082 bp
Tssr134029	Chr15:36608611-36608621 (-)	1,209 bp
Tssr134028	Chr15:36608599-36608604 (-)	1,223 bp
Tssr134027	Chr15:36608090-36608099 (-)	1,730 bp
Tssr134026	Chr15:36605759-36605798 (-)	4,046 bp
Tssr134025	Chr15:36601163-36601184 (-)	8,651 bp
Tssr134024	Chr15:36598341-36598368 (-)	11,470 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24