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Dpysl3 Gene Detail
Summary
  • Symbol
    Dpysl3
  • Name
    dihydropyrimidinase-like 3
  • Synonyms
    9430041P20Rik, CRMP-4, CRMP4, TUC4, Ulip, Ulip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349762
    NCBI Gene: 22240
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:43454049-43571351 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, Syntenic
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3397 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349762
 protein coding gene Chr18:43454044-43571354 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024385
 protein coding gene Chr18:42021120-42152822 (-)
A/J MGP_AJ_G0024352
 protein coding gene Chr18:40548347-40661822 (-)
AKR/J MGP_AKRJ_G0024321
 protein coding gene Chr18:41660603-41779922 (-)
BALB/cJ MGP_BALBcJ_G0024352
 protein coding gene Chr18:40634341-40750762 (-)
C3H/HeJ MGP_C3HHeJ_G0024118
 protein coding gene Chr18:41721032-41840554 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024794
 protein coding gene Chr18:43497531-43623951 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022232
 protein coding gene Chr18:40375510-40485311 (-)
CAST/EiJ MGP_CASTEiJ_G0023593
 protein coding gene Chr18:41699209-41833365 (-)
CBA/J MGP_CBAJ_G0024088
 protein coding gene Chr18:44723472-44837574 (-)
DBA/2J MGP_DBA2J_G0024218
 protein coding gene Chr18:40138047-40252924 (-)
FVB/NJ MGP_FVBNJ_G0024184
 protein coding gene Chr18:39744459-39865338 (-)
LP/J MGP_LPJ_G0024302
 protein coding gene Chr18:42061751-42185717 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024215
 protein coding gene Chr18:46023171-46144833 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024843
 protein coding gene Chr18:41545159-41664493 (-)
PWK/PhJ MGP_PWKPhJ_G0023337
 protein coding gene Chr18:40320278-40472764 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023142
 protein coding gene Chr18:41697398-41899585 (-)
WSB/EiJ MGP_WSBEiJ_G0023656
 protein coding gene Chr18:41464301-41584961 (-)



Homology
more
  • Human Ortholog
    DPYSL3, dihydropyrimidinase like 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPYSL3, dihydropyrimidinase like 3
  • Synonyms
    CRMP-4, CRMP4, DRP-3, DRP3, LCRMP, ULIP, ULIP-1
  • Links
    NCBI Gene ID: 1809
    neXtProt AC: NX_Q14195
    UniProt: Q14195

  • Chr Location
    5q32; chr5:147390808-147510068 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired axon extension, abnormal neuron growth cones morphology and impaired anterograde transportation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1004
  • Tissues
    158
  • cDNA Data
    16
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024501 Ensembl Gene Model | MGI Sequence Detail 117303 C57BL/6J ±  kb
    transcript ENSMUST00000121805 Ensembl | MGI Sequence Detail 5479 Not Applicable  
    polypeptide ENSMUSP00000112928 Ensembl | MGI Sequence Detail 683 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000006681 dihydropyrimidinase-related protein 3
      (term hierarchy)
    • InterPro Domains
      IPR006680 Amidohydrolase-related
      IPR011778 Hydantoinase/dihydropyrimidinase
      IPR032466 Metal-dependent hydrolase
      IPR011059 Metal-dependent hydrolase, composite domain superfamily
      IPR050378 Metallo-dependent Hydrolases Superfamily
    • GlyGen
      Q62188 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37079, MGI:108043, MGI:1924595
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 20
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:30653 Byk T, et al., Identification and molecular characterization of Unc-33-like phosphoprotein (Ulip), a putative mammalian homolog of the axonal guidance-associated unc-33 gene product. J Neurosci. 1996 Jan 15;16(2):688-701
    • Latest
      J:321443 Osawa K, et al., CRMP4 is required for the positioning and maturation of newly generated neurons in adult mouse hippocampus. Neurosci Lett. 2022 Mar 16;773:136503
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory