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Cadps Gene Detail
Summary
  • Symbol
    Cadps
  • Name
    Ca2+-dependent secretion activator
  • Synonyms
    CAPS1, mKIAA1121
  • Feature Type
    protein coding gene
  • IDs
    MGI:1350922
    NCBI Gene: 27062
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:9646684-10097200 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 6.37 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12199 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1350922
 protein coding gene Chr14:9646424-10097203 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021000
 protein coding gene Chr14:4785494-5281063 (-)
A/J MGP_AJ_G0020948
 protein coding gene Chr14:4694377-5155124 (-)
AKR/J MGP_AKRJ_G0020925
 protein coding gene Chr14:4773697-5251519 (-)
BALB/cJ MGP_BALBcJ_G0020951
 protein coding gene Chr14:4684169-5137974 (-)
C3H/HeJ MGP_C3HHeJ_G0020735
 protein coding gene Chr14:4805765-5290338 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021384
 protein coding gene Chr14:4963780-5433970 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018953
 protein coding gene Chr14:5425630-5867744 (-)
CAST/EiJ MGP_CASTEiJ_G0020257
 protein coding gene Chr14:4796075-5263577 (-)
CBA/J MGP_CBAJ_G0020701
 protein coding gene Chr14:5096704-5612493 (-)
DBA/2J MGP_DBA2J_G0020824
 protein coding gene Chr14:4636044-5102106 (-)
FVB/NJ MGP_FVBNJ_G0020806
 protein coding gene Chr14:4601669-5057333 (-)
LP/J MGP_LPJ_G0020900
 protein coding gene Chr14:4751065-5241181 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020832
 protein coding gene Chr14:5196636-5685443 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021417
 protein coding gene Chr14:4754026-5225573 (-)
PWK/PhJ MGP_PWKPhJ_G0020009
 protein coding gene Chr14:4644350-5113196 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019829
 protein coding gene Chr14:4808562-5306970 (-)
WSB/EiJ MGP_WSBEiJ_G0020315
 protein coding gene Chr14:4776464-5250576 (-)



Homology
more
  • Human Ortholog
    CADPS, calcium dependent secretion activator
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CADPS, calcium dependent secretion activator
  • Synonyms
    CADPS1, CAPS, CAPS1, UNC-31
  • Links
    NCBI Gene ID: 8618
    neXtProt AC: NX_Q9ULU8
    UniProt: Q9ULU8

  • Chr Location
    3p14.2; chr3:62398346-62875416 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality, respiratory failure and abnormal adrenal gland physiology. Adult heterozygous null mice display abnormal adrenal gland physiology that is different from that seen in homozygous neonates.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1059
  • Tissues
    131
  • cDNA Data
    65
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054423 Ensembl Gene Model | MGI Sequence Detail 450517 C57BL/6J ±  kb
    transcript ENSMUST00000067491 Ensembl | MGI Sequence Detail 5421 Not Applicable  
    polypeptide ENSMUSP00000064706 Ensembl | MGI Sequence Detail 1361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      cDNA 66
      Primer pair 7
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145766
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 17
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:80393 Cisternas FA, et al., Cloning and characterization of human CADPS and CADPS2, new members of the Ca(2+)-dependent activator for secretion protein family. Genomics. 2003 Mar;81(3):279-91
    • Latest
      J:351960 Shumate KM, et al., RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission. J Neurochem. 2021 Jul;158(2):182-196
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory