Sh3d19 MGI Mouse Gene Detail - MGI:1350923

Symbol

Sh3d19
Name

SH3 domain protein D19
Synonyms

Kryn

Feature Type

protein coding gene
IDs

MGI:1350923
NCBI Gene: 27059
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr3:85878416-86037833 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 37.83 cM, cytoband F1
Mapping Data

4 experiments

SNPs within 2kb

4470 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1350923	protein coding gene	Chr3:85878112-86037833 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027351	protein coding gene	Chr3:86000485-86164640 (+)
A/J	MGP_AJ_G0027315	protein coding gene	Chr3:83091849-83249804 (+)
AKR/J	MGP_AKRJ_G0027281	protein coding gene	Chr3:85065241-85250732 (+)
BALB/cJ	MGP_BALBcJ_G0027324	protein coding gene	Chr3:83176952-83336461 (+)
C3H/HeJ	MGP_C3HHeJ_G0027068	protein coding gene	Chr3:85389670-85549704 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027770	protein coding gene	Chr3:89182945-89350118 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025123	protein coding gene	Chr3:78740852-78897807 (+)
CAST/EiJ	MGP_CASTEiJ_G0026515	protein coding gene	Chr3:85584142-85753562 (+)
CBA/J	MGP_CBAJ_G0027043	protein coding gene	Chr3:92166982-92339714 (+)
DBA/2J	MGP_DBA2J_G0027179	protein coding gene	Chr3:82588527-82747475 (+)
FVB/NJ	MGP_FVBNJ_G0027147	protein coding gene	Chr3:80891635-81052540 (+)
LP/J	MGP_LPJ_G0027287	protein coding gene	Chr3:86934487-87101784 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027166	protein coding gene	Chr3:98442248-98613512 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027828	protein coding gene	Chr3:84867614-85032633 (+)
PWK/PhJ	MGP_PWKPhJ_G0026249	protein coding gene	Chr3:82397173-82561708 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026065	protein coding gene	Chr3:84028663-84192133 (+)
WSB/EiJ	MGP_WSBEiJ_G0026593	protein coding gene	Chr3:85241001-85401098 (+)

Human Ortholog

SH3D19, SH3 domain containing 19

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SH3D19, SH3 domain containing 19
Synonyms

EBP, Eve-1, EVE1, Kryn, SH3P19
Links

HGNC:30418

NCBI Gene ID: 152503

neXtProt AC: NX_Q5HYK7

UniProt: Q5HYK7
Chr Location

4q31.3; chr4:151102751-151325605 (-) GRCh38

MGI Vertebrate Homology

Sh3d19 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SH3D19
Gene Tree

Sh3d19

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

58
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

55
Radiation induced

1
Genomic Mutations

2 involving Sh3d19
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

6
cDNA Data

64
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sh3d19

ZFIN sh3d19

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All Sequences

73
RefSeq

18
UniProt

4
CCDS

CCDS38469.2, CCDS89646.1

Ensembl

ENSMUSG00000028082 (Evidence)
NCBI Gene

27059

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028082	Ensembl Gene Model \| MGI Sequence Detail	159418	C57BL/6J	± kb
transcript	ENSMUST00000238443	Ensembl \| MGI Sequence Detail	7217	Not Applicable
polypeptide	ENSMUSP00000158699	Ensembl \| MGI Sequence Detail	1065	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014822 SH3 domain-containing protein 19

(term hierarchy)
InterPro Domains

IPR001452 SH3 domain

IPR035834 SH3 domain-containing protein 19, SH3 domain 1

IPR035835 SH3 domain-containing protein 19, SH3 domain 3

IPR036028 SH3-like domain superfamily

IPR050670 Signal Transducing Adapter Molecule

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All nucleic 66

cDNA 66

Microarray probesets 4

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MGI:2139947

Summaries

All 39

Developmental Gene Expression 1

Diseases 1

Gene Ontology 4

Phenotypes 13
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sh3d19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29770	Chr3:85878377-85878482 (+)	14 bp
Tssr29771	Chr3:85878528-85878543 (+)	120 bp
Tssr29772	Chr3:85906174-85906178 (+)	27,760 bp
Tssr29773	Chr3:85918897-85918921 (+)	40,493 bp
Tssr29774	Chr3:85924538-85924552 (+)	46,129 bp
Tssr29775	Chr3:85946144-85946198 (+)	67,755 bp
Tssr29776	Chr3:85947838-85947878 (+)	69,442 bp
Tssr29777	Chr3:85948112-85948132 (+)	69,706 bp
Tssr29778	Chr3:86011331-86011370 (+)	132,935 bp
Tssr29779	Chr3:86011506-86011524 (+)	133,099 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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