Aoah Gene Detail

Summary

• Symbol
  Aoah
• Name
  acyloxyacyl hydrolase
• Synonyms
  4930433E13Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1350928
  NCBI Gene: 27052
• Alliance
  gene page
• Transcription Start Sites
  137 TSS

Location &
Maps

• Sequence Map
  Chr13:20978283-21220787 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 13, 7.49 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  7007 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1350928	protein coding gene	Chr13:20978273-21220787 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020265	protein coding gene	Chr13:18020630-18261671 (+)
A/J	MGP_AJ_G0020222	protein coding gene	Chr13:17655038-17864547 (+)
AKR/J	MGP_AKRJ_G0020196	protein coding gene	Chr13:17923930-18152652 (+)
BALB/cJ	MGP_BALBcJ_G0020208	protein coding gene	Chr13:17705942-17926206 (+)
C3H/HeJ	MGP_C3HHeJ_G0020011	protein coding gene	Chr13:18029772-18258748 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020652	protein coding gene	Chr13:18664717-18904615 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018259	protein coding gene	Chr13:16057956-16260991 (+)
CAST/EiJ	MGP_CASTEiJ_G0019546	protein coding gene	Chr13:17815511-18044687 (+)
CBA/J	MGP_CBAJ_G0019975	protein coding gene	Chr13:19323923-19563398 (+)
DBA/2J	MGP_DBA2J_G0020094	protein coding gene	Chr13:17275335-17496206 (+)
FVB/NJ	MGP_FVBNJ_G0020076	protein coding gene	Chr13:16938512-17173278 (+)
LP/J	MGP_LPJ_G0020165	protein coding gene	Chr13:18260900-18506715 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020114	protein coding gene	Chr13:19736764-19973655 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020681	protein coding gene	Chr13:17751832-17988259 (+)
PWK/PhJ	MGP_PWKPhJ_G0019309	protein coding gene	Chr13:17341135-17555988 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019115	protein coding gene	Chr13:16770131-16998477 (+)
WSB/EiJ	MGP_WSBEiJ_G0019605	protein coding gene	Chr13:17810218-18055995 (+)

Homology

• Human Ortholog
  AOAH, acyloxyacyl hydrolase

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  AOAH, acyloxyacyl hydrolase
  
• Links
  HGNC:548

  NCBI Gene ID: 313

  neXtProt AC: NX_P28039

  UniProt: P28039

  
  
• Chr Location
  7p14.2; chr7:36512941-36724549 (-)  GRCh38

---

• MGI Vertebrate Homology
  Aoah stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: AOAH
• Gene Tree
  Aoah
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  32 phenotype references
  

• All Mutations and Alleles
  22
• Chemically induced (other)
  1
• Endonuclease-mediated
  4
• Gene trapped
  14
• Radiation induced
  1
• Targeted
  2
• Genomic Mutations
  2 involving Aoah
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  53 strains or lines available

Homozygous null mice have a reduced ability to deacylate bacterial lipopolysaccharides.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  16
• GO References
  7

Expression

• Assay Results
  707
• Tissues
  1
• cDNA Data
  21
• Literature Summary
  2

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase aoah

Sequences &
Gene Models

• All Sequences
  65
• RefSeq
  16
• UniProt
  7
• CCDS
  CCDS26266.1, CCDS88418.1

• Ensembl
  ENSMUSG00000021322 (Evidence)
• NCBI Gene
  27052

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000021322	Ensembl Gene Model | MGI Sequence Detail	242505	C57BL/6J
transcript	ENSMUST00000021757	Ensembl | MGI Sequence Detail	2921	Not Applicable
polypeptide	ENSMUSP00000021757	Ensembl | MGI Sequence Detail	574	Not Applicable

Protein
Information

• UniProt
  7 Sequences
• Protein Ontology
  PR:000004085 acyloxyacyl hydrolase
  (term hierarchy)
• PDB
  5W7D, 5W7E, 5W7F
• EC
  3.1.1.77
• InterPro Domains
  IPR039676 Acyloxyacyl hydrolase
  IPR048593 Acyloxyacyl hydrolase, N-terminal domain
  IPR001087 GDSL lipase/esterase
  IPR008139 Saposin B type domain
  IPR011001 Saposin-like
  IPR036514 SGNH hydrolase superfamily
• GlyGen
  O35298 4 sites

Molecular
Reagents

• All nucleic 22

  cDNA 22

  
  

  Microarray probesets 5

Other
Accession IDs

MGI:1921929

References

• Summaries
  All 63

  Developmental Gene Expression 2

  Gene Ontology 7

  Phenotypes 32
• Earliest
  J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Aoah:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118602	Chr13:20978298-20978349 (+)	41 bp
Tssr118603	Chr13:20978357-20978374 (+)	83 bp
Tssr118604	Chr13:20978382-20978393 (+)	105 bp
Tssr118605	Chr13:20978468-20978477 (+)	190 bp
Tssr118606	Chr13:20978482-20978534 (+)	225 bp
Tssr118607	Chr13:20978615-20978622 (+)	336 bp
Tssr118608	Chr13:20979090-20979112 (+)	818 bp
Tssr118609	Chr13:20980559-20980561 (+)	2,277 bp
Tssr118610	Chr13:20980588-20980637 (+)	2,330 bp
Tssr118611	Chr13:20980679-20980696 (+)	2,405 bp
Tssr118612	Chr13:20981840-20981854 (+)	3,564 bp
Tssr118613	Chr13:20983262-20983274 (+)	4,985 bp
Tssr118614	Chr13:20984208-20984234 (+)	5,938 bp
Tssr118615	Chr13:20985335-20985347 (+)	7,058 bp
Tssr118616	Chr13:20985782-20985790 (+)	7,503 bp
Tssr118617	Chr13:20986050-20986082 (+)	7,783 bp
Tssr118618	Chr13:20987283-20987302 (+)	9,010 bp
Tssr118619	Chr13:20989340-20989350 (+)	11,062 bp
Tssr118620	Chr13:20989351-20989360 (+)	11,073 bp
Tssr118621	Chr13:20998098-20998104 (+)	19,818 bp
Tssr118622	Chr13:21001955-21001991 (+)	23,690 bp
Tssr118623	Chr13:21002503-21002524 (+)	24,231 bp
Tssr118624	Chr13:21002989-21003015 (+)	24,719 bp
Tssr118625	Chr13:21003038-21003047 (+)	24,760 bp
Tssr118626	Chr13:21008315-21008345 (+)	30,047 bp
Tssr118627	Chr13:21008854-21008896 (+)	30,592 bp
Tssr118628	Chr13:21009440-21009444 (+)	31,159 bp
Tssr118634	Chr13:21013524-21013537 (+)	35,248 bp
Tssr118635	Chr13:21013704-21013725 (+)	35,432 bp
Tssr118636	Chr13:21015275-21015286 (+)	36,998 bp
Tssr118637	Chr13:21015294-21015304 (+)	37,016 bp
Tssr118638	Chr13:21019854-21019865 (+)	41,577 bp
Tssr118639	Chr13:21020073-21020077 (+)	41,792 bp
Tssr118640	Chr13:21020131-21020136 (+)	41,851 bp
Tssr118641	Chr13:21020214-21020219 (+)	41,934 bp
Tssr118642	Chr13:21020241-21020256 (+)	41,966 bp
Tssr118643	Chr13:21020278-21020283 (+)	41,998 bp
Tssr118644	Chr13:21020291-21020302 (+)	42,014 bp
Tssr118645	Chr13:21020334-21020337 (+)	42,053 bp
Tssr118646	Chr13:21020369-21020380 (+)	42,092 bp
Tssr118647	Chr13:21020383-21020410 (+)	42,114 bp
Tssr118648	Chr13:21021388-21021410 (+)	43,116 bp
Tssr118649	Chr13:21025031-21025067 (+)	46,766 bp
Tssr118650	Chr13:21025128-21025139 (+)	46,851 bp
Tssr118651	Chr13:21026206-21026218 (+)	47,929 bp
Tssr118652	Chr13:21026388-21026395 (+)	48,109 bp
Tssr118653	Chr13:21026400-21026421 (+)	48,128 bp
Tssr118654	Chr13:21026489-21026501 (+)	48,212 bp
Tssr118655	Chr13:21030202-21030206 (+)	51,921 bp
Tssr118656	Chr13:21030934-21030944 (+)	52,656 bp
Tssr118657	Chr13:21031433-21031442 (+)	53,155 bp
Tssr118658	Chr13:21031882-21031896 (+)	53,606 bp
Tssr118659	Chr13:21032001-21032020 (+)	53,728 bp
Tssr118660	Chr13:21033687-21033697 (+)	55,409 bp
Tssr118661	Chr13:21033882-21033893 (+)	55,605 bp
Tssr118662	Chr13:21034164-21034211 (+)	55,905 bp
Tssr118663	Chr13:21035559-21035571 (+)	57,282 bp
Tssr118664	Chr13:21036897-21036911 (+)	58,621 bp
Tssr118665	Chr13:21036959-21036970 (+)	58,682 bp
Tssr118666	Chr13:21037797-21037808 (+)	59,520 bp
Tssr118667	Chr13:21038002-21038031 (+)	59,734 bp
Tssr118668	Chr13:21038045-21038060 (+)	59,770 bp
Tssr118669	Chr13:21038067-21038087 (+)	59,794 bp
Tssr118670	Chr13:21038089-21038116 (+)	59,820 bp
Tssr118671	Chr13:21038224-21038233 (+)	59,946 bp
Tssr118672	Chr13:21038979-21038991 (+)	60,702 bp
Tssr118673	Chr13:21039864-21039875 (+)	61,587 bp
Tssr118674	Chr13:21039998-21040007 (+)	61,720 bp
Tssr118675	Chr13:21041478-21041491 (+)	63,202 bp
Tssr118676	Chr13:21041942-21041956 (+)	63,666 bp
Tssr118677	Chr13:21042512-21042530 (+)	64,238 bp
Tssr118678	Chr13:21043423-21043433 (+)	65,145 bp
Tssr118679	Chr13:21043756-21043768 (+)	65,479 bp
Tssr118680	Chr13:21043853-21043862 (+)	65,575 bp
Tssr118681	Chr13:21044782-21044791 (+)	66,504 bp
Tssr118682	Chr13:21044800-21044811 (+)	66,523 bp
Tssr118683	Chr13:21068267-21068273 (+)	89,987 bp
Tssr118684	Chr13:21069242-21069253 (+)	90,965 bp
Tssr118685	Chr13:21069278-21069306 (+)	91,009 bp
Tssr118686	Chr13:21069312-21069322 (+)	91,034 bp
Tssr118687	Chr13:21069381-21069432 (+)	91,124 bp
Tssr118688	Chr13:21069452-21069462 (+)	91,174 bp
Tssr118689	Chr13:21069468-21069521 (+)	91,212 bp
Tssr118690	Chr13:21069527-21069537 (+)	91,249 bp
Tssr118691	Chr13:21070683-21070700 (+)	92,409 bp
Tssr118692	Chr13:21079724-21079746 (+)	101,452 bp
Tssr118693	Chr13:21080678-21080688 (+)	102,400 bp
Tssr118694	Chr13:21081798-21081819 (+)	103,526 bp
Tssr118695	Chr13:21083415-21083432 (+)	105,141 bp
Tssr118696	Chr13:21083772-21083794 (+)	105,500 bp
Tssr118697	Chr13:21083808-21083833 (+)	105,538 bp
Tssr118698	Chr13:21087060-21087071 (+)	108,783 bp
Tssr118699	Chr13:21087086-21087114 (+)	108,817 bp
Tssr118700	Chr13:21087140-21087153 (+)	108,864 bp
Tssr118701	Chr13:21087179-21087199 (+)	108,906 bp
Tssr118702	Chr13:21087219-21087230 (+)	108,942 bp
Tssr118703	Chr13:21092719-21092720 (+)	114,437 bp
Tssr118704	Chr13:21094830-21094842 (+)	116,553 bp
Tssr118705	Chr13:21101829-21101846 (+)	123,555 bp
Tssr118706	Chr13:21107109-21107121 (+)	128,832 bp
Tssr118707	Chr13:21107160-21107182 (+)	128,888 bp
Tssr118708	Chr13:21107239-21107250 (+)	128,962 bp
Tssr118709	Chr13:21107278-21107289 (+)	129,001 bp
Tssr118710	Chr13:21107312-21107331 (+)	129,039 bp
Tssr118711	Chr13:21107337-21107348 (+)	129,060 bp
Tssr118712	Chr13:21107564-21107576 (+)	129,287 bp
Tssr118713	Chr13:21108061-21108069 (+)	129,782 bp
Tssr118714	Chr13:21108931-21108941 (+)	130,653 bp
Tssr118715	Chr13:21118138-21118170 (+)	139,871 bp
Tssr118716	Chr13:21118761-21118782 (+)	140,489 bp
Tssr118717	Chr13:21118828-21118861 (+)	140,562 bp
Tssr118718	Chr13:21120551-21120579 (+)	142,282 bp
Tssr118719	Chr13:21120742-21120758 (+)	142,467 bp
Tssr118720	Chr13:21129216-21129220 (+)	150,935 bp
Tssr118721	Chr13:21140883-21140897 (+)	162,607 bp
Tssr118722	Chr13:21143748-21143763 (+)	165,473 bp
Tssr118723	Chr13:21143846-21143854 (+)	165,567 bp
Tssr118724	Chr13:21148053-21148071 (+)	169,779 bp
Tssr118725	Chr13:21148261-21148272 (+)	169,984 bp
Tssr118726	Chr13:21148717-21148721 (+)	170,436 bp
Tssr118727	Chr13:21150832-21150848 (+)	172,557 bp
Tssr118728	Chr13:21162215-21162218 (+)	183,934 bp
Tssr118729	Chr13:21169305-21169316 (+)	191,028 bp
Tssr118730	Chr13:21170332-21170347 (+)	192,057 bp
Tssr118731	Chr13:21170374-21170383 (+)	192,096 bp
Tssr118732	Chr13:21170393-21170405 (+)	192,116 bp
Tssr118733	Chr13:21170464-21170476 (+)	192,187 bp
Tssr118734	Chr13:21170501-21170522 (+)	192,229 bp
Tssr118735	Chr13:21170565-21170580 (+)	192,290 bp
Tssr118736	Chr13:21170587-21170632 (+)	192,327 bp
Tssr118737	Chr13:21177540-21177544 (+)	199,259 bp
Tssr118738	Chr13:21184129-21184175 (+)	205,869 bp
Tssr118739	Chr13:21185894-21185911 (+)	207,620 bp
Tssr118740	Chr13:21186878-21186891 (+)	208,602 bp
Tssr118741	Chr13:21187628-21187632 (+)	209,347 bp
Tssr118742	Chr13:21192750-21192764 (+)	214,474 bp
Tssr118743	Chr13:21208111-21208153 (+)	229,849 bp