Srp9 MGI Mouse Gene Detail - MGI:1350930 - signal recognition particle 9

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Srp9 Gene Detail

Symbol

Srp9
Name

signal recognition particle 9
Synonyms

9kDa

Feature Type

protein coding gene
IDs

MGI:1350930
NCBI Gene: 27058
Alliance

gene page
Transcription Start Sites

4 TSS
Candidate for QTL

3 QTL

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Sequence Map

Chr1:181952302-181959972 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 84.93 cM
Mapping Data

2 experiments

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SNPs within 2kb

416 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1350930	protein coding gene	Chr1:181952302-181959980 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016890	protein coding gene	Chr1:188742260-188751494 (+)
A/J	MGP_AJ_G0016869	protein coding gene	Chr1:181042653-181050905 (+)
AKR/J	MGP_AKRJ_G0016835	protein coding gene	Chr1:186442899-186453596 (+)
BALB/cJ	MGP_BALBcJ_G0016827	protein coding gene	Chr1:181685099-181693500 (+)
C3H/HeJ	MGP_C3HHeJ_G0016652	protein coding gene	Chr1:187225010-187233795 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017290	protein coding gene	Chr1:194829663-194837327 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014997	protein coding gene	Chr1:171996352-172004686 (+)
CAST/EiJ	MGP_CASTEiJ_G0016233	protein coding gene	Chr1:186580551-186592908 (+)
CBA/J	MGP_CBAJ_G0016626	protein coding gene	Chr1:202067260-202075427 (+)
DBA/2J	MGP_DBA2J_G0016732	protein coding gene	Chr1:179858859-179867030 (+)
FVB/NJ	MGP_FVBNJ_G0016728	protein coding gene	Chr1:177978317-177986489 (+)
LP/J	MGP_LPJ_G0016806	protein coding gene	Chr1:189938022-189946482 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016759	protein coding gene	Chr1:209108370-209116547 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017327	protein coding gene	Chr1:186243988-186251585 (+)
PWK/PhJ	MGP_PWKPhJ_G0016021	protein coding gene	Chr1:179019492-179027785 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015797	protein coding gene	Chr1:185195207-185203385 (+)
WSB/EiJ	MGP_WSBEiJ_G0016296	protein coding gene	Chr1:186441678-186449893 (+)

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Human Ortholog

SRP9, signal recognition particle 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRP9, signal recognition particle 9
Synonyms

ALURBP
Links

HGNC:11304

NCBI Gene ID: 6726

neXtProt AC: NX_P49458

UniProt: P49458
Chr Location

1q42.12; chr1:225777813-225790468 (+) GRCh38

MGI Vertebrate Homology

Srp9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SRP9
Protein SuperFamily

Signal_recog_particle_SRP9
Gene Tree

Srp9

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

2
Gene trapped

18
Targeted

3
Genomic Mutations

2 involving Srp9
Incidental Mutations

APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

754
Tissues

41
cDNA Data

118
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase srp9

ZFIN srp9

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All Sequences

51
RefSeq

2
UniProt

4
CCDS

CCDS35812.1

Ensembl

ENSMUSG00000026511 (Evidence)
NCBI Gene

27058

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000026511	Ensembl Gene Model \| MGI Sequence Detail	7671	C57BL/6J	± kb
	transcript	ENSMUST00000027792	Ensembl \| MGI Sequence Detail	1367	Not Applicable
	polypeptide	ENSMUSP00000027792	Ensembl \| MGI Sequence Detail	86	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015628 signal recognition particle 9 kDa protein

(term hierarchy)
PDB

1914
InterPro Domains

IPR008832 Signal recognition particle SRP9

IPR039914 Signal recognition particle SRP9-like

IPR009018 Signal recognition particle, SRP9/SRP14 subunit

IPR039432 SRP9 domain

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All nucleic 119

cDNA 119

Microarray probesets 5

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Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 10
Earliest

J:38553 Bovia F, et al., The SRP9/14 subunit of the human signal recognition particle binds to a variety of Alu-like RNAs and with higher affinity than its mouse homolog. Nucleic Acids Res. 1997 Jan 15;25(2):318-26
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Srp9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10537	Chr1:181952203-181952214 (+)	-93 bp
Tssr10538	Chr1:181952339-181952365 (+)	50 bp
Tssr10539	Chr1:181952367-181952383 (+)	73 bp
Tssr10540	Chr1:181952956-181952960 (+)	656 bp

Srp9 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Actre1	Chr1, 81.08 cM		J:98587	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to 6 previously identified alcohol-related QTLs to identify potential candidate genes. Two different Affymetrix microarrays were used in the analysis. Brain expression data from parental strains and 56 (DBA/2J x C57BL/6J)F2 intercross animals were used for analysis. On mouse Chromosome 1, several candidate genes were identified for Alcw1 at 95.8 cM, Alcdp1 (95.8 cM), and Actre1 (85 cM). The highest priority candidate genes identified for chromosome 1 ethanol-related QTLs are Myoc (83.6 cM), Pou2f1 (87.2 cM), Mgst3, Aldh9a1, Sdhc, Kcnj9 (94.2 cM), Darc (94 cM), and Srp9. Other candidate genes with a ranking of modest priority were identified but are not listed here.
Alcdp1	Chr1, 80.33 cM		J:98587	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to 6 previously identified alcohol-related QTLs to identify potential candidate genes. Two different Affymetrix microarrays were used in the analysis. Brain expression data from parental strains and 56 (DBA/2J x C57BL/6J)F2 intercross animals were used for analysis. On mouse Chromosome 1, several candidate genes were identified for Alcw1 at 95.8 cM, Alcdp1 (95.8 cM), and Actre1 (85 cM). The highest priority candidate genes identified for chromosome 1 ethanol-related QTLs are Myoc (83.6 cM), Pou2f1 (87.2 cM), Mgst3, Aldh9a1, Sdhc, Kcnj9 (94.2 cM), Darc (94 cM), and Srp9. Other candidate genes with a ranking of modest priority were identified but are not listed here.
Alcw1	Chr1, 80.33 cM	Chr1:170868354-171966357	J:98587	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to 6 previously identified alcohol-related QTLs to identify potential candidate genes. Two different Affymetrix microarrays were used in the analysis. Brain expression data from parental strains and 56 (DBA/2J x C57BL/6J)F2 intercross animals were used for analysis. On mouse Chromosome 1, several candidate genes were identified for Alcw1 at 95.8 cM, Alcdp1 (95.8 cM), and Actre1 (85 cM). The highest priority candidate genes identified for chromosome 1 ethanol-related QTLs are Myoc (83.6 cM), Pou2f1 (87.2 cM), Mgst3, Aldh9a1, Sdhc, Kcnj9 (94.2 cM), Darc (94 cM), and Srp9. Other candidate genes with a ranking of modest priority were identified but are not listed here.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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