Ncoa4 MGI Mouse Gene Detail - MGI:1350932 - nuclear receptor coactivator 4

Symbol

Ncoa4
Name

nuclear receptor coactivator 4
Synonyms

1110034E15Rik, 4432406M01Rik

Feature Type

protein coding gene
IDs

MGI:1350932
NCBI Gene: 27057
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr14:31881884-31901210 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 19.40 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

480 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1350932	protein coding gene	Chr14:31881822-31901812 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021139	protein coding gene	Chr14:25392831-25413029 (+)
A/J	MGP_AJ_G0021087	protein coding gene	Chr14:24422969-24442960 (+)
AKR/J	MGP_AKRJ_G0021064	protein coding gene	Chr14:25569574-25589561 (+)
BALB/cJ	MGP_BALBcJ_G0021091	protein coding gene	Chr14:24598823-24620760 (+)
C3H/HeJ	MGP_C3HHeJ_G0020874	protein coding gene	Chr14:25446065-25466050 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021523	protein coding gene	Chr14:26402974-26429397 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019086	protein coding gene	Chr14:24488002-24508296 (+)
CAST/EiJ	MGP_CASTEiJ_G0020399	protein coding gene	Chr14:25237030-25257003 (+)
CBA/J	MGP_CBAJ_G0020841	protein coding gene	Chr14:27393099-27413162 (+)
DBA/2J	MGP_DBA2J_G0020963	protein coding gene	Chr14:24455978-24475998 (+)
FVB/NJ	MGP_FVBNJ_G0020947	protein coding gene	Chr14:24415665-24438127 (+)
LP/J	MGP_LPJ_G0021032	protein coding gene	Chr14:25715350-25736154 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020973	protein coding gene	Chr14:26631430-26651538 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021556	protein coding gene	Chr14:25343975-25363967 (+)
PWK/PhJ	MGP_PWKPhJ_G0020147	protein coding gene	Chr14:23926488-23947232 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019971	protein coding gene	Chr14:24950538-24970437 (+)
WSB/EiJ	MGP_WSBEiJ_G0020454	protein coding gene	Chr14:25405941-25425981 (+)

Human Ortholog

NCOA4, nuclear receptor coactivator 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NCOA4, nuclear receptor coactivator 4
Synonyms

ARA70, ELE1, PTC3, RFG
Links

HGNC:7671

NCBI Gene ID: 8031

neXtProt AC: NX_Q13772

UniProt: Q13772
Chr Location

10q11.22; chr10:46005088-46030623 (-) GRCh38

MGI Vertebrate Homology

Ncoa4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NCOA4
Gene Tree

Ncoa4

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

72
Endonuclease-mediated

7
Gene trapped

60
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

77 strains or lines available

Mouse embryonic fibroblasts isolated from homozygous null mice exhibit abnormal DNA replication, decreased fibroblast proliferation, and early cellular replicative senescence.

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All GO Annotations

5
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

891
Tissues

101
cDNA Data

23
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NCOA4

Xenbase ncoa4

ZFIN ncoa4

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All Sequences

116
RefSeq

34
UniProt

12
CCDS

CCDS36863.1

Ensembl

ENSMUSG00000056234 (Evidence)
NCBI Gene

27057

			Length	Strain/Species	Flank
genomic	27057	NCBI Gene Model \| MGI Sequence Detail	19327	C57BL/6J	± kb
transcript	NM_001284319	RefSeq \| MGI Sequence Detail	3484	C57BL/6
polypeptide	Q5U4H9	UniProt \| EBI \| MGI Sequence Detail	625	Not Applicable

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UniProt

12 Sequences
InterPro Domains

IPR022174 Nuclear coactivator

IPR039947 Nuclear receptor coactivator 4

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All nucleic 25

cDNA 24

Primer pair 1

Microarray probesets 5

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MGI:1913942, MGI:1915907, MGI:2145605

Summaries

All 51

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 17
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:341244 Jin L, et al., STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury. Free Radic Biol Med. 2023 Aug 25;208:348-360

TSS for Ncoa4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124966	Chr14:31881289-31881310 (+)	-584 bp
Tssr124967	Chr14:31881858-31881946 (+)	18 bp
Tssr124968	Chr14:31887485-31887498 (+)	5,608 bp
Tssr124969	Chr14:31887530-31887556 (+)	5,659 bp
Tssr124970	Chr14:31887715-31887724 (+)	5,836 bp
Tssr124971	Chr14:31887741-31887755 (+)	5,864 bp
Tssr124972	Chr14:31887776-31887788 (+)	5,898 bp
Tssr124973	Chr14:31887797-31887813 (+)	5,921 bp
Tssr124974	Chr14:31887831-31887862 (+)	5,963 bp
Tssr124975	Chr14:31888061-31888080 (+)	6,187 bp
Tssr124976	Chr14:31897609-31897611 (+)	15,726 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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