About   Help   FAQ
Tlx2 Gene Detail
Summary
  • Symbol
    Tlx2
  • Name
    T cell leukemia, homeobox 2
  • Synonyms
    Enx, Hox11l1, Hox11L.1, NCX, Ncx1, Tlx1l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1350935
    NCBI Gene: 21909
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83045306-83047206 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM, cytoband C3-D1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1350935
 protein coding gene Chr6:83045305-83047274 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030914
 protein coding gene Chr6:84071842-84073811 (-)
A/J MGP_AJ_G0030883
 protein coding gene Chr6:80859252-80861221 (-)
AKR/J MGP_AKRJ_G0030811
 protein coding gene Chr6:83188147-83190116 (-)
BALB/cJ MGP_BALBcJ_G0030893
 protein coding gene Chr6:80871924-80873893 (-)
C3H/HeJ MGP_C3HHeJ_G0030817
 protein coding gene Chr6:101191934-101193903 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031353
 protein coding gene Chr6:86351365-86353334 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028539
 protein coding gene Chr6:79217507-79219455 (-)
CAST/EiJ MGP_CASTEiJ_G0030002
 protein coding gene Chr6:83188567-83190529 (-)
CBA/J MGP_CBAJ_G0030580
 protein coding gene Chr6:89763657-89765626 (-)
DBA/2J MGP_DBA2J_G0030733
 protein coding gene Chr6:80179021-80180990 (-)
FVB/NJ MGP_FVBNJ_G0030686
 protein coding gene Chr6:79385826-79387795 (-)
LP/J MGP_LPJ_G0030812
 protein coding gene Chr6:84065916-84067885 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030722
 protein coding gene Chr6:94068988-94070957 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031377
 protein coding gene Chr6:83002119-83004075 (-)
PWK/PhJ MGP_PWKPhJ_G0029717
 protein coding gene Chr6:79071527-79073482 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029545
 protein coding gene Chr6:81847478-81849440 (-)
WSB/EiJ MGP_WSBEiJ_G0030083
 protein coding gene Chr6:83440478-83442447 (-)



Homology
more
  • Human Ortholog
    TLX2, T cell leukemia homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLX2, T cell leukemia homeobox 2
  • Synonyms
    HOX11L1, NCX
  • Links
    NCBI Gene ID: 3196
    neXtProt AC: NX_O43763
    UniProt: O43763

  • Chr Location
    2p13.1; chr2:74513463-74517148 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tlx2 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 4 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for two targeted null mutations exhibit megacolon with hyperinnervated enteric ganglia which undergo neuronal degeneration. Homozygotes for a third null mutation die in utero with defects in formation of the primitive streak and mesoderm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    981
  • Tissues
    187
  • cDNA Data
    13
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21909 NCBI Gene Model | MGI Sequence Detail 1901 C57BL/6J ±  kb
    transcript NM_009392 RefSeq | MGI Sequence Detail 1434 ZRU/MplStud  
    polypeptide Q61663 UniProt | EBI | MGI Sequence Detail 284 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 5
      cDNA 14
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15138, MGD-MRK-26032, MGD-MRK-26033, MGD-MRK-27029, MGI:104666, MGI:98770
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 14
      Diseases 2
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:12674 Kennedy MA, et al., HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8900-4
    • Latest
      J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory