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Pla2g7 Gene Detail
Summary
  • Symbol
    Pla2g7
  • Name
    phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
  • Synonyms
    PAF acetylhydrolase, PAF-AH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351327
    NCBI Gene: 27226
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:43879009-43923093 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.74 cM, cytoband C
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1826 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351327
 protein coding gene Chr17:43878989-43923093 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023776
 protein coding gene Chr17:44461638-44511119 (+)
A/J MGP_AJ_G0023734
 protein coding gene Chr17:43462259-43507701 (+)
AKR/J MGP_AKRJ_G0023705
 protein coding gene Chr17:43704505-43748512 (+)
BALB/cJ MGP_BALBcJ_G0023738
 protein coding gene Chr17:43354704-43399748 (+)
C3H/HeJ MGP_C3HHeJ_G0023502
 protein coding gene Chr17:44395366-44445709 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024181
 protein coding gene Chr17:46450082-46495660 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021631
 protein coding gene Chr17:40289551-40333678 (+)
CAST/EiJ MGP_CASTEiJ_G0022983
 protein coding gene Chr17:44430045-44481794 (+)
CBA/J MGP_CBAJ_G0023478
 protein coding gene Chr17:48086062-48132366 (+)
DBA/2J MGP_DBA2J_G0023604
 protein coding gene Chr17:42265293-42309280 (+)
FVB/NJ MGP_FVBNJ_G0023571
 protein coding gene Chr17:41827155-41873249 (+)
LP/J MGP_LPJ_G0023685
 protein coding gene Chr17:45128650-45176455 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023600
 protein coding gene Chr17:47729073-47777793 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024226
 protein coding gene Chr17:44054156-44099442 (+)
PWK/PhJ MGP_PWKPhJ_G0022728
 protein coding gene Chr17:41516646-41563454 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022543
 protein coding gene Chr17:40918758-40966724 (+)
WSB/EiJ MGP_WSBEiJ_G0023048
 protein coding gene Chr17:44571865-44619869 (+)



Homology
more
  • Human Ortholog
    PLA2G7, phospholipase A2 group VII
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLA2G7, phospholipase A2 group VII
  • Synonyms
    LDL-PLA2, LP-PLA2, PAFAD, PAFAH
  • Links
    NCBI Gene ID: 7941
    neXtProt AC: NX_Q13093
    UniProt: Q13093

  • Chr Location
    6p12.3; chr6:46704201-46735721 (-)  GRCh38
Human Diseases
more
  • Diseases
    10 with human PLA2G7 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced early mortality in response to bacterial exposure, formula feeding and asphyxia, but survivors show a significantly higher incidence of necrotizing enterocolitis relative to wild-type controls.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    980
  • Tissues
    144
  • cDNA Data
    13
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27226 NCBI Gene Model | MGI Sequence Detail 44085 C57BL/6J ±  kb
    transcript NM_013737 RefSeq | MGI Sequence Detail 1855 C57BL/6  
    polypeptide Q60963 UniProt | EBI | MGI Sequence Detail 440 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 13
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147157
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 16
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:29539 Tjoelker LW, et al., Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic triad. J Biol Chem. 1995 Oct 27;270(43):25481-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory