Chaf1a MGI Mouse Gene Detail - MGI:1351331 - chromatin assembly factor 1, subunit A

Symbol

Chaf1a
Name

chromatin assembly factor 1, subunit A
Synonyms

CAF-1, p150

Feature Type

protein coding gene
IDs

MGI:1351331
NCBI Gene: 27221
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr17:56347404-56375027 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 29.13 cM, cytoband D
Mapping Data

2 experiments

SNPs within 2kb

650 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351331	protein coding gene	Chr17:56347404-56379289 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023909	protein coding gene	Chr17:57670615-57705666 (+)
A/J	MGP_AJ_G0023869	protein coding gene	Chr17:56113969-56144537 (+)
AKR/J	MGP_AKRJ_G0023838	protein coding gene	Chr17:56797876-56827997 (+)
BALB/cJ	MGP_BALBcJ_G0023870	protein coding gene	Chr17:55948890-55979686 (+)
C3H/HeJ	MGP_C3HHeJ_G0023633	protein coding gene	Chr17:57505411-57533307 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024314	protein coding gene	Chr17:59952976-59995808 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021761	protein coding gene	Chr17:52630603-52658026 (+)
CAST/EiJ	MGP_CASTEiJ_G0023116	protein coding gene	Chr17:57816687-57851390 (+)
CBA/J	MGP_CBAJ_G0023610	protein coding gene	Chr17:62258529-62287849 (+)
DBA/2J	MGP_DBA2J_G0023738	protein coding gene	Chr17:54846822-54874191 (+)
FVB/NJ	MGP_FVBNJ_G0023704	protein coding gene	Chr17:54365790-54394050 (+)
LP/J	MGP_LPJ_G0023818	protein coding gene	Chr17:58388547-58417079 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023731	protein coding gene	Chr17:61815412-61844841 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024359	protein coding gene	Chr17:57172190-57201551 (+)
PWK/PhJ	MGP_PWKPhJ_G0022861	protein coding gene	Chr17:54189475-54217289 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022673	protein coding gene	Chr17:53939898-53973316 (+)
WSB/EiJ	MGP_WSBEiJ_G0023180	protein coding gene	Chr17:57785733-57819254 (+)

Human Ortholog

CHAF1A, chromatin assembly factor 1 subunit A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHAF1A, chromatin assembly factor 1 subunit A
Synonyms

CAF-1, CAF1, CAF1B, CAF1P150, P150
Links

HGNC:1910

NCBI Gene ID: 10036

neXtProt AC: NX_Q13111

UniProt: Q13111
Chr Location

19p13.3; chr19:4402640-4450830 (+) GRCh38

MGI Vertebrate Homology

Chaf1a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CHAF1A
Gene Tree

Chaf1a

Diseases

4 with human CHAF1A associations

				Human Disease	Mouse Models
				colon cancer IDs colon cancer DOID:219 ICD10CM:C18 ICD9CM:153 ICD9CM:153.9 MESH:D003110 NCI:C9242 UMLS_CUI:C0007102
				high grade glioma IDs high grade glioma DOID:3070 DOID:2627 KEGG:05214 MESH:D005910 NCI:C3059 NCI:C4822 OMIM:PS137800 ORDO:182067 UMLS_CUI:C0017638 UMLS_CUI:C0555198
				neuroblastoma IDs neuroblastoma DOID:769 EFO:0000621 MESH:D009447 NCI:C3270 ORDO:635 UMLS_CUI:C0027819
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

1
Gene trapped

27
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

46 strains or lines available

Mice homozygous for a null mutation in this gene display lethality before implantation, embryonic growth arrest, and abnormal heterochromatin morphology.

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All GO Annotations

22
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

9
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase chaf1a

ZFIN chaf1a

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All Sequences

42
RefSeq

2
UniProt

3
CCDS

CCDS28892.1

Ensembl

ENSMUSG00000002835 (Evidence)
NCBI Gene

27221

			Length	Strain/Species	Flank
genomic	27221	NCBI Gene Model \| MGI Sequence Detail	27624	C57BL/6J	± kb
transcript	NM_013733	RefSeq \| MGI Sequence Detail	3321	C57BL/6
polypeptide	Q9QWF0	UniProt \| EBI \| MGI Sequence Detail	911	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005402 chromatin assembly factor 1 subunit A

(term hierarchy)
PDB

1S4Z
InterPro Domains

IPR022043 Chromatin assembly factor 1 subunit A

IPR029105 Chromatin assembly factor 1 subunit p150, C-terminal

IPR029091 Chromatin assembly factor 1 subunit p150, N-terminal
GlyGen

Q9QWF0 1 site, 1 O-linked glycan (1 site)

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All nucleic 9

cDNA 9

Microarray probesets 3

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MGI:2146952, MGI:2146957

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 9
Earliest

J:58148 Murzina N, et al., Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins. Mol Cell. 1999 Oct;4(4):529-40
Latest

J:282456 Cheng L, et al., Chromatin Assembly Factor 1 (CAF-1) facilitates the establishment of facultative heterochromatin during pluripotency exit. Nucleic Acids Res. 2019 Dec 2;47(21):11114-11131

TSS for Chaf1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145275	Chr17:56347331-56347349 (+)	-64 bp
Tssr145276	Chr17:56347350-56347420 (+)	-19 bp
Tssr145277	Chr17:56347424-56347445 (+)	31 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24