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Grm1 Gene Detail
Summary
  • Symbol
    Grm1
  • Name
    glutamate receptor, metabotropic 1
  • Synonyms
    4930455H15Rik, Gprc1a, Grm1, mGluR1, nmf373, rcw
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351338
    NCBI Gene: 14816
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:10561803-10958100 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 3.44 cM, cytoband A2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9730 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351338
 protein coding gene Chr10:10561803-10958126 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017011
 protein coding gene Chr10:8048758-8452053 (-)
A/J MGP_AJ_G0016989
 protein coding gene Chr10:7664077-8063331 (-)
AKR/J MGP_AKRJ_G0016953
 protein coding gene Chr10:7854241-8262948 (-)
BALB/cJ MGP_BALBcJ_G0016947
 protein coding gene Chr10:7653208-8077808 (-)
C3H/HeJ MGP_C3HHeJ_G0016772
 protein coding gene Chr10:8017958-8422530 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017409
 protein coding gene Chr10:8221470-8652121 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015114
 protein coding gene Chr10:7084424-7468042 (-)
CAST/EiJ MGP_CASTEiJ_G0016354
 protein coding gene Chr10:7886598-8289687 (-)
CBA/J MGP_CBAJ_G0016744
 protein coding gene Chr10:8509539-8955487 (-)
DBA/2J MGP_DBA2J_G0016852
 protein coding gene Chr10:7594391-7982108 (-)
FVB/NJ MGP_FVBNJ_G0016847
 protein coding gene Chr10:7506259-7885555 (-)
LP/J MGP_LPJ_G0016927
 protein coding gene Chr10:7838139-8247079 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016877
 protein coding gene Chr10:8428458-8863737 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017447
 protein coding gene Chr10:7800115-8197861 (-)
PWK/PhJ MGP_PWKPhJ_G0016139
 protein coding gene Chr10:7511320-7901855 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015922
 protein coding gene Chr10:7833058-8245697 (-)
WSB/EiJ MGP_WSBEiJ_G0016416
 protein coding gene Chr10:7798911-8219059 (-)



Homology
more
  • Human Ortholog
    GRM1, glutamate metabotropic receptor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRM1, glutamate metabotropic receptor 1
  • Synonyms
    GPRC1A, MGLU1, MGLUR1, PPP1R85, SCA44, SCAR13
  • Links
    NCBI Gene ID: 2911
    neXtProt AC: NX_Q13255
    UniProt: Q13255

  • Chr Location
    6q24.3; chr6:146027646-146437601 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Grm1 mouse models; 2 with human GRM1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 2 models
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    61 phenotypes from 14 alleles in 15 genetic backgrounds
    7 phenotypes from multigenic genotypes
    96 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations show impairements in motor coordination, spatial learning, hippocampal mossy fiber long-term potentiation, and cerebellar long-term depression. Homozygotes for a spontaneous mutation are small and exhibit ataxia, kyphoscoliosis, albuminuria and glomerular damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1080
  • Tissues
    208
  • cDNA Data
    13
  • Literature Summary
    35
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019828 Ensembl Gene Model | MGI Sequence Detail 396298 C57BL/6J ±  kb
    transcript ENSMUST00000044306 Ensembl | MGI Sequence Detail 6930 Not Applicable  
    polypeptide ENSMUSP00000037255 Ensembl | MGI Sequence Detail 1199 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008263 metabotropic glutamate receptor 1
      (term hierarchy)
    • InterPro Domains
      IPR000337 GPCR, family 3
      IPR017979 GPCR, family 3, conserved site
      IPR017978 GPCR family 3, C-terminal
      IPR000162 GPCR, family 3, metabotropic glutamate receptor
      IPR001256 GPCR, family 3, metabotropic glutamate receptor 1
      IPR011500 GPCR, family 3, nine cysteines domain
      IPR038550 GPCR, family 3, nine cysteines domain superfamily
      IPR050726 Metabotropic Glutamate Receptor
      IPR019588 Metabotropic glutamate receptor, Homer-binding domain
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      P97772 6 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 14
      Primer pair 4
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10264, MGI:1922125, MGI:2652657, MGI:3584411, MGI:3588965, MGI:95825
    References
    more
    • Summaries
      All 222
      Developmental Gene Expression 35
      Diseases 3
      Gene Ontology 19
      Phenotypes 96
    • Earliest
      J:11894 Colon-Teicher L, et al., Genomic sequences capable of committing mouse and rat fibroblasts to adipogenesis. Nucleic Acids Res. 1993 May 11;21(9):2223-8
    • Latest
      J:348733 Staebler S, et al., Transcription factor activating enhancer-binding protein 2epsilon (AP2epsilon) modulates phenotypic plasticity and progression of malignant melanoma. Cell Death Dis. 2024 May 21;15(5):351
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory