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Grm5 Gene Detail
Summary
  • Symbol
    Grm5
  • Name
    glutamate receptor, metabotropic 5
  • Synonyms
    6430542K11Rik, Glu5R, Gprc1e, mGluR5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351342
    NCBI Gene: 108071
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:87233376-87784115 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 49.01 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13926 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351342
 protein coding gene Chr7:87233212-87784271 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032491
 protein coding gene Chr7:89931620-90505878 (+)
A/J MGP_AJ_G0032465
 protein coding gene Chr7:87768668-88334046 (+)
AKR/J MGP_AKRJ_G0032401
 protein coding gene Chr7:89904783-90418158 (+)
BALB/cJ MGP_BALBcJ_G0032476
 protein coding gene Chr7:87487437-88024659 (+)
C3H/HeJ MGP_C3HHeJ_G0032191
 protein coding gene Chr7:90251689-90803236 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032974
 protein coding gene Chr7:93504438-94053798 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029969
 protein coding gene Chr7:90461371-91352952 (+)
CAST/EiJ MGP_CASTEiJ_G0031518
 protein coding gene Chr7:81661850-82237767 (+)
CBA/J MGP_CBAJ_G0032157
 protein coding gene Chr7:96556038-97168646 (+)
DBA/2J MGP_DBA2J_G0032310
 protein coding gene Chr7:86278837-86808310 (+)
FVB/NJ MGP_FVBNJ_G0032266
 protein coding gene Chr7:86144389-86679312 (+)
LP/J MGP_LPJ_G0032399
 protein coding gene Chr7:91183203-91749298 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032300
 protein coding gene Chr7:97524100-98205314 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032996
 protein coding gene Chr7:89127883-89706421 (+)
PWK/PhJ MGP_PWKPhJ_G0031236
 protein coding gene Chr7:79285739-79835635 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031079
 protein coding gene Chr7:76444585-76997694 (+)
WSB/EiJ MGP_WSBEiJ_G0031635
 protein coding gene Chr7:89765808-90328120 (+)



Homology
more
  • Human Ortholog
    GRM5, glutamate metabotropic receptor 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRM5, glutamate metabotropic receptor 5
  • Synonyms
    GPRC1E, mGlu5, MGLUR5, PPP1R86
  • Links
    NCBI Gene ID: 2915
    neXtProt AC: NX_P41594
    UniProt: P41594

  • Chr Location
    11q14.2-q14.3; chr11:88504576-89065982 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Grm5 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 6 alleles in 9 genetic backgrounds
    5 phenotypes from multigenic genotypes
    141 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have reduced corticostriatal long term potentiation, do not exhibit hyperactivity after cocaine consumption and do not self-administer cocaine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    54
  • cDNA Data
    5
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049583 Ensembl Gene Model | MGI Sequence Detail 550740 C57BL/6J ±  kb
    transcript ENSMUST00000155358 Ensembl | MGI Sequence Detail 4500 Not Applicable  
    polypeptide ENSMUSP00000114927 Ensembl | MGI Sequence Detail 1203 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000008267 metabotropic glutamate receptor 5
      (term hierarchy)
    • InterPro Domains
      IPR000337 GPCR, family 3
      IPR017979 GPCR, family 3, conserved site
      IPR017978 GPCR family 3, C-terminal
      IPR000162 GPCR, family 3, metabotropic glutamate receptor
      IPR000202 GPCR, family 3, metabotropic glutamate receptor 5
      IPR011500 GPCR, family 3, nine cysteines domain
      IPR038550 GPCR, family 3, nine cysteines domain superfamily
      IPR050726 Metabotropic Glutamate Receptor
      IPR019588 Metabotropic glutamate receptor, Homer-binding domain
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      Q3UVX5 12 sites, 7 N-linked glycans (6 sites), 1 O-linked glycan (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 2
      cDNA 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10268, MGI:2142054, MGI:95829
    References
    more
    • Summaries
      All 265
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 15
      Phenotypes 141
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:359487 Ramos-Prats A, et al., Loss of mGlu(5) receptors in somatostatin-expressing neurons alters negative emotional states. Mol Psychiatry. 2024 Sep;29(9):2774-2786
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory