G3bp1 MGI Mouse Gene Detail - MGI:1351465 - G3BP stress granule assembly factor 1

Symbol

G3bp1
Name

G3BP stress granule assembly factor 1
Synonyms

GAP SH3 binding protein

Feature Type

protein coding gene
IDs

MGI:1351465
NCBI Gene: 27041
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:55360521-55391722 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 33.09 cM
Mapping Data

2 experiments

SNPs within 2kb

781 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351465	protein coding gene	Chr11:55360511-55395664 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018332	protein coding gene	Chr11:55005736-55043198 (+)
A/J	MGP_AJ_G0018301	protein coding gene	Chr11:52957214-52993779 (+)
AKR/J	MGP_AKRJ_G0018270	protein coding gene	Chr11:54682655-54720108 (+)
BALB/cJ	MGP_BALBcJ_G0018272	protein coding gene	Chr11:53280931-53322683 (+)
C3H/HeJ	MGP_C3HHeJ_G0018083	protein coding gene	Chr11:54616075-54648431 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018724	protein coding gene	Chr11:56667525-56705999 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016374	protein coding gene	Chr11:50370719-50405891 (+)
CAST/EiJ	MGP_CASTEiJ_G0017648	protein coding gene	Chr11:54657028-54686299 (+)
CBA/J	MGP_CBAJ_G0018058	protein coding gene	Chr11:59365282-59405421 (+)
DBA/2J	MGP_DBA2J_G0018167	protein coding gene	Chr11:52637328-52672725 (+)
FVB/NJ	MGP_FVBNJ_G0018159	protein coding gene	Chr11:52305414-52341538 (+)
LP/J	MGP_LPJ_G0018242	protein coding gene	Chr11:55465777-55501666 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018185	protein coding gene	Chr11:60540203-60576446 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018766	protein coding gene	Chr11:54702633-54748359 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0017216	protein coding gene	Chr11:54492368-54534410 (+)
WSB/EiJ	MGP_WSBEiJ_G0017696	protein coding gene	Chr11:54345953-54377098 (+)

Human Ortholog

G3BP1, G3BP stress granule assembly factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

G3BP1, G3BP stress granule assembly factor 1
Synonyms

G3BP, HDH-VIII
Links

HGNC:30292

NCBI Gene ID: 10146

neXtProt AC: NX_Q13283

UniProt: Q13283
Chr Location

5q33.1; chr5:151771045-151812911 (+) GRCh38

MGI Vertebrate Homology

G3bp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: G3BP1
Gene Tree

G3bp1

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References

1 with disease annotations

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

64
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

53
Targeted

5
Genomic Mutations

2 involving G3bp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

73 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display perinatal lethality with severe cell death in the nervous system and decreased cell proliferation. Neonates from heterozygous null female mice display increased mortality.

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All GO Annotations

52
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

897
Tissues

159
cDNA Data

14
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA G3BP1

Xenbase g3bp1

ZFIN g3bp1

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All Sequences

57
RefSeq

10
UniProt

3
CCDS

CCDS24714.1

Ensembl

ENSMUSG00000018583 (Evidence)
NCBI Gene

27041

			Length	Strain/Species	Flank
genomic	27041	NCBI Gene Model \| MGI Sequence Detail	31202	C57BL/6J	± kb
transcript	NM_001417587	RefSeq \| MGI Sequence Detail	3112	C57BL/6
polypeptide	P97855	UniProt \| EBI \| MGI Sequence Detail	465	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007743 Ras GTPase-activating protein-binding protein 1

(term hierarchy)
EC

3.6.4.12, 3.6.4.13
InterPro Domains

IPR034374 G3BP1, RNA recognition motif

IPR032710 NTF2-like domain superfamily

IPR002075 Nuclear transport factor 2 domain

IPR018222 Nuclear transport factor 2, eukaryote

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR039539 Ras GTPase-activating protein-binding protein

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain
GlyGen

P97855 6 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (4 sites)

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All nucleic 25

cDNA 15

Primer pair 9

Other 1

Microarray probesets 6

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MGI:2144303, MGI:2144694

Summaries

All 76

Developmental Gene Expression 7

Diseases 1

Gene Ontology 13

Phenotypes 28
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for G3bp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101622	Chr11:55360474-55360485 (+)	-41 bp
Tssr101623	Chr11:55360503-55360542 (+)	2 bp
Tssr101624	Chr11:55360550-55360568 (+)	38 bp
Tssr101625	Chr11:55360991-55361007 (+)	478 bp
Tssr101626	Chr11:55387393-55387400 (+)	26,876 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24