Plek2 MGI Mouse Gene Detail - MGI:1351466

Symbol

Plek2
Name

pleckstrin 2

Feature Type

protein coding gene
IDs

MGI:1351466
NCBI Gene: 27260
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:78935465-78953738 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 35.51 cM, cytoband D3
Mapping Data

3 experiments

SNPs within 2kb

641 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351466	protein coding gene	Chr12:78935465-78955166 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019875	protein coding gene	Chr12:79164840-79184957 (-)
A/J	MGP_AJ_G0019833	protein coding gene	Chr12:76315739-76333804 (-)
AKR/J	MGP_AKRJ_G0019808	protein coding gene	Chr12:78385907-78403814 (-)
BALB/cJ	MGP_BALBcJ_G0019812	protein coding gene	Chr12:76568637-76586660 (-)
C3H/HeJ	MGP_C3HHeJ_G0019618	protein coding gene	Chr12:78856504-78875800 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020264	protein coding gene	Chr12:81506839-81526253 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017882	protein coding gene	Chr12:73337912-73357177 (-)
CAST/EiJ	MGP_CASTEiJ_G0019168	protein coding gene	Chr12:73685042-73709006 (-)
CBA/J	MGP_CBAJ_G0019588	protein coding gene	Chr12:84671809-84694029 (-)
DBA/2J	MGP_DBA2J_G0019704	protein coding gene	Chr12:75942995-75961277 (-)
FVB/NJ	MGP_FVBNJ_G0019690	protein coding gene	Chr12:74753731-74772118 (-)
LP/J	MGP_LPJ_G0019776	protein coding gene	Chr12:79090436-79110719 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019729	protein coding gene	Chr12:87729605-87747836 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020300	protein coding gene	Chr12:77901643-77922359 (-)
PWK/PhJ	MGP_PWKPhJ_G0018934	protein coding gene	Chr12:70281589-70302493 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018728	protein coding gene	Chr12:72402604-72423166 (-)
WSB/EiJ	MGP_WSBEiJ_G0019221	protein coding gene	Chr12:78498475-78519747 (-)

Human Ortholog

PLEK2, pleckstrin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLEK2, pleckstrin 2
Links

HGNC:19238

NCBI Gene ID: 26499

neXtProt AC: NX_Q9NYT0

UniProt: Q9NYT0
Chr Location

14q23.3-q24.1; chr14:67386984-67412167 (-) GRCh38

MGI Vertebrate Homology

Plek2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLEK2
Gene Tree

Plek2

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

2
Genomic Mutations

1 involving Plek2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Knockout mice exhibit mild anemia with aging, mild ineffective erythropoiesis, slightly enlarged spleen and increased sensitivity of peripheral red blood cells to oxidative damage.

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All GO Annotations

15
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

10
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

6
UniProt

1
CCDS

CCDS26004.1

Ensembl

ENSMUSG00000021118 (Evidence)
NCBI Gene

27260

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021118	Ensembl Gene Model \| MGI Sequence Detail	18274	C57BL/6J	± kb
transcript	ENSMUST00000021544	Ensembl \| MGI Sequence Detail	1583	Not Applicable
polypeptide	ENSMUSP00000021544	Ensembl \| MGI Sequence Detail	353	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000012852 pleckstrin-2

(term hierarchy)
PDB

1V3F
InterPro Domains

IPR000591 DEP domain

IPR011993 PH-like domain superfamily

IPR037370 Pleckstrin

IPR037369 Pleckstrin-2, DEP domain

IPR001849 Pleckstrin homology domain

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 10

cDNA 10

Microarray probesets 2

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 12
Earliest

J:58788 Inazu T, et al., Cloning and expression of pleckstrin 2, a novel member of the pleckstrin family. Biochem Biophys Res Commun. 1999 Nov;265(1):87-93
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Plek2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116800	Chr12:78955149-78955161 (-)	-1,417 bp
Tssr116799	Chr12:78953703-78953744 (-)	14 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24