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Pdk4 Gene Detail
Summary
  • Symbol
    Pdk4
  • Name
    pyruvate dehydrogenase kinase, isoenzyme 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351481
    NCBI Gene: 27273
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:5483351-5496278 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 2.06 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    438 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351481
 protein coding gene Chr6:5483351-5496309 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030436
 protein coding gene Chr6:2330366-2345876 (-)
A/J MGP_AJ_G0030409
 protein coding gene Chr6:2241805-2254902 (-)
AKR/J MGP_AKRJ_G0030336
 protein coding gene Chr6:2309494-2322425 (-)
BALB/cJ MGP_BALBcJ_G0030418
 protein coding gene Chr6:2216547-2229983 (-)
C3H/HeJ MGP_C3HHeJ_G0030132
 protein coding gene Chr6:2282130-2296610 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030873
 protein coding gene Chr6:2392986-2408102 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028084
 protein coding gene Chr6:1929873-1942829 (-)
CAST/EiJ MGP_CASTEiJ_G0029533
 protein coding gene Chr6:2268340-2281129 (-)
CBA/J MGP_CBAJ_G0030110
 protein coding gene Chr6:2473033-2488431 (-)
DBA/2J MGP_DBA2J_G0030254
 protein coding gene Chr6:2204080-2217107 (-)
FVB/NJ MGP_FVBNJ_G0030208
 protein coding gene Chr6:2193219-2206173 (-)
LP/J MGP_LPJ_G0030341
 protein coding gene Chr6:2283158-2301388 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030244
 protein coding gene Chr6:2540972-2557898 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030903
 protein coding gene Chr6:2265440-2278597 (-)
PWK/PhJ MGP_PWKPhJ_G0029248
 protein coding gene Chr6:2134413-2147210 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029084
 protein coding gene Chr6:2310537-2323414 (-)
WSB/EiJ MGP_WSBEiJ_G0029610
 protein coding gene Chr6:2255290-2268157 (-)



Homology
more
  • Human Ortholog
    PDK4, pyruvate dehydrogenase kinase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDK4, pyruvate dehydrogenase kinase 4
  • Links
    NCBI Gene ID: 5166
    neXtProt AC: NX_Q16654
    UniProt: Q16654

  • Chr Location
    7q21.3; chr7:95583499-95596516 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered glucose homoeostasis during starvation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    849
  • Tissues
    58
  • cDNA Data
    37
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27273 NCBI Gene Model | MGI Sequence Detail 12928 C57BL/6J ±  kb
    transcript NM_013743 RefSeq | MGI Sequence Detail 3453 ZRU/MplStud  
    polypeptide O70571 UniProt | EBI | MGI Sequence Detail 412 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012507 [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
      (term hierarchy)
    • EC
      2.7.11.-, 2.7.11.2
    • InterPro Domains
      IPR036784 Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
      IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
      IPR005467 Histidine kinase domain
      IPR003594 Histidine kinase/HSP90-like ATPase
      IPR036890 Histidine kinase/HSP90-like ATPase superfamily
      IPR039028 PDK/BCKDK protein kinase
    • GlyGen
      O70571 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 37
      Primer pair 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141608
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 13
      Gene Ontology 15
      Phenotypes 31
    • Earliest
      J:58666 Bowker-Kinley M, et al., Evidence that pyruvate dehydrogenase kinase belongs to the ATPase/kinase superfamily. Biochem J. 1999 Nov 15;344 Pt 1:47-53
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory