Dok3 MGI Mouse Gene Detail - MGI:1351490

Symbol

Dok3
Name

docking protein 3
Synonyms

p62Dok-like protein

Feature Type

protein coding gene
IDs

MGI:1351490
NCBI Gene: 27261
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:55671044-55677109 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 30.06 cM
Mapping Data

1 experiment

SNPs within 2kb

185 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351490	protein coding gene	Chr13:55671044-55678158 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020601	protein coding gene	Chr13:55012647-55017952 (-)
A/J	MGP_AJ_G0020555	protein coding gene	Chr13:52978026-52983366 (-)
AKR/J	MGP_AKRJ_G0020533	protein coding gene	Chr13:54543815-54549381 (-)
BALB/cJ	MGP_BALBcJ_G0020551	protein coding gene	Chr13:53210298-53215625 (-)
C3H/HeJ	MGP_C3HHeJ_G0020350	protein coding gene	Chr13:54354928-54360291 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020985	protein coding gene	Chr13:56669848-56675107 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018567	protein coding gene	Chr13:50916183-50921723 (-)
CAST/EiJ	MGP_CASTEiJ_G0019864	protein coding gene	Chr13:54457814-54463153 (-)
CBA/J	MGP_CBAJ_G0020310	protein coding gene	Chr13:58848043-58853383 (-)
DBA/2J	MGP_DBA2J_G0020433	protein coding gene	Chr13:52529233-52534540 (-)
FVB/NJ	MGP_FVBNJ_G0020412	protein coding gene	Chr13:52000044-52005344 (-)
LP/J	MGP_LPJ_G0020509	protein coding gene	Chr13:55265646-55270956 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020441	protein coding gene	Chr13:58312130-58317432 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021028	protein coding gene	Chr13:54123746-54129021 (-)
PWK/PhJ	MGP_PWKPhJ_G0019620	protein coding gene	Chr13:52556274-52561670 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019447	protein coding gene	Chr13:53053298-53058639 (-)
WSB/EiJ	MGP_WSBEiJ_G0019926	protein coding gene	Chr13:54482601-54487920 (-)

Human Ortholog

DOK3, docking protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DOK3, docking protein 3
Synonyms

DOKL
Links

HGNC:24583

NCBI Gene ID: 79930

neXtProt AC: NX_Q7L591

UniProt: Q7L591
Chr Location

5q35.3; chr5:177501904-177511274 (-) GRCh38

MGI Vertebrate Homology

Dok3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DOK3
Gene Tree

Dok3

Diseases

1 with human DOK3 associations

				Human Disease	Mouse Models
				colorectal adenocarcinoma IDs colorectal adenocarcinoma DOID:0050861 NCI:C5105 UMLS_CUI:C1319315

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 3 alleles in 3 genetic backgrounds
13 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

7
Genomic Mutations

2 involving Dok3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased incidence of lung adenocarcinomas. Mice for another null alelle show increased IgM antibodies and have enchanced humoral immune responses to T cell-independent type I and II antigens.

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All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

26

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

4
UniProt

3
CCDS

CCDS26548.1

Ensembl

ENSMUSG00000035711 (Evidence)
NCBI Gene

27261

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035711	Ensembl Gene Model \| MGI Sequence Detail	6066	C57BL/6J	± kb
transcript	ENSMUST00000223563	Ensembl \| MGI Sequence Detail	1644	Not Applicable
polypeptide	ENSMUSP00000153308	Ensembl \| MGI Sequence Detail	444	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006630 docking protein 3

(term hierarchy)
InterPro Domains

IPR050996 Docking Protein Family (DOK)

IPR037751 Dok1/2/3, PTB domain

IPR002404 IRS-type PTB domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

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All nucleic 28

Genomic 2

cDNA 26

Microarray probesets 3

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MGI:2145244

Summaries

All 48

Diseases 1

Gene Ontology 4

Phenotypes 19
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:336030 Loh JT, et al., Dok3 restrains neutrophil production of calprotectin during TLR4 sensing of SARS-CoV-2 spike protein. Front Immunol. 2022;13:996637

TSS for Dok3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122716	Chr13:55677193-55677198 (-)	-87 bp
Tssr122715	Chr13:55677153-55677180 (-)	-58 bp
Tssr122714	Chr13:55676375-55676393 (-)	725 bp
Tssr122713	Chr13:55676324-55676374 (-)	760 bp
Tssr122712	Chr13:55676258-55676262 (-)	849 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24