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Dguok Gene Detail
Summary
  • Symbol
    Dguok
  • Name
    deoxyguanosine kinase
  • Synonyms
    dGK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351602
    NCBI Gene: 27369
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83457199-83483887 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    695 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351602
 protein coding gene Chr6:83457199-83483951 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030932
 protein coding gene Chr6:84485728-84512489 (-)
A/J MGP_AJ_G0030901
 protein coding gene Chr6:81275329-81304501 (-)
AKR/J MGP_AKRJ_G0030829
 protein coding gene Chr6:83628938-83655724 (-)
BALB/cJ MGP_BALBcJ_G0030911
 protein coding gene Chr6:81300272-81327107 (-)
C3H/HeJ MGP_C3HHeJ_G0030799
 protein coding gene Chr6:100734221-100760890 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031371
 protein coding gene Chr6:86812642-86839320 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028557
 protein coding gene Chr6:79629516-79655920 (-)
CAST/EiJ MGP_CASTEiJ_G0030020
 protein coding gene Chr6:83647647-83675610 (-)
CBA/J MGP_CBAJ_G0030598
 protein coding gene Chr6:90217967-90244648 (-)
DBA/2J MGP_DBA2J_G0030751
 protein coding gene Chr6:80592712-80619396 (-)
FVB/NJ MGP_FVBNJ_G0030704
 protein coding gene Chr6:79801110-79827935 (-)
LP/J MGP_LPJ_G0030830
 protein coding gene Chr6:84495174-84521921 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030740
 protein coding gene Chr6:94526390-94553141 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031395
 protein coding gene Chr6:83441041-83467718 (-)
PWK/PhJ MGP_PWKPhJ_G0029735
 protein coding gene Chr6:79497667-79525301 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029563
 protein coding gene Chr6:82289338-82316966 (-)
WSB/EiJ MGP_WSBEiJ_G0030101
 protein coding gene Chr6:83875784-83902710 (-)



Homology
more
  • Human Ortholog
    DGUOK, deoxyguanosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DGUOK, deoxyguanosine kinase
  • Synonyms
    dGK, MTDPS3, NCPH, NCPH1, PEOB4
  • Links
    NCBI Gene ID: 1716
    neXtProt AC: NX_Q16854
    UniProt: Q16854

  • Chr Location
    2p13.1; chr2:73926826-73958961 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human DGUOK associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit weight loss, absent subcutaneous fat tissue, severe mtDNA depletion and mitochondrial dysfunction in the liver with signs of oxidative stress, liver damage and regeneration, increased catabolic lipid metabolism, and a progressive change in fur color.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    843
  • Tissues
    123
  • cDNA Data
    43
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27369 NCBI Gene Model | MGI Sequence Detail 26689 C57BL/6J ±  kb
    transcript NR_177096 RefSeq | MGI Sequence Detail 1104 ZRU/MplStud  
    polypeptide Q9QX60 UniProt | EBI | MGI Sequence Detail 277 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 44

      Microarray probesets 4
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Gene Ontology 15
      Phenotypes 16
    • Earliest
      J:306870 Barker J, et al., Deoxyguanosine kinase of neonatal mouse skin tissue. Biochim Biophys Acta. 1981 Mar 13;658(1):111-23
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory