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Rpl3 Gene Detail
Summary
  • Symbol
    Rpl3
  • Name
    ribosomal protein L3
  • Synonyms
    F2, J1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351605
    NCBI Gene: 27367
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79961993-79967553 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    306 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351605
 protein coding gene Chr15:79961992-79976069 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022092
 protein coding gene Chr15:80384388-80400809 (-)
A/J MGP_AJ_G0022053
 protein coding gene Chr15:77608802-77623960 (-)
AKR/J MGP_AKRJ_G0022028
 protein coding gene Chr15:79777598-79791816 (-)
BALB/cJ MGP_BALBcJ_G0022059
 protein coding gene Chr15:77611574-77631361 (-)
C3H/HeJ MGP_C3HHeJ_G0021830
 protein coding gene Chr15:79764015-79780303 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022502
 protein coding gene Chr15:83545222-83567643 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020032
 protein coding gene Chr15:74088714-74102767 (-)
CAST/EiJ MGP_CASTEiJ_G0021351
 protein coding gene Chr15:80482243-80497266 (-)
CBA/J MGP_CBAJ_G0021795
 protein coding gene Chr15:86186131-86208347 (-)
DBA/2J MGP_DBA2J_G0021924
 protein coding gene Chr15:77101333-77115942 (-)
FVB/NJ MGP_FVBNJ_G0021902
 protein coding gene Chr15:76122573-76128515 (-)
LP/J MGP_LPJ_G0021992
 protein coding gene Chr15:80571190-80587554 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021922
 protein coding gene Chr15:91226901-91246770 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022516
 protein coding gene Chr15:79804742-79823259 (-)
PWK/PhJ MGP_PWKPhJ_G0021093
 protein coding gene Chr15:77107429-77123970 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020930
 protein coding gene Chr15:79611783-79627471 (-)
WSB/EiJ MGP_WSBEiJ_G0021403
 protein coding gene Chr15:80207905-80222509 (-)



Homology
more
  • Human Ortholog
    RPL3, ribosomal protein L3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPL3, ribosomal protein L3
  • Synonyms
    ASC-1, L3, TARBP-B, uL3
  • Links
    NCBI Gene ID: 6122
    neXtProt AC: NX_P39023
    UniProt: P39023

  • Chr Location
    22q13.1; chr22:39312882-39320389 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    21
  • Radiation induced
    2
  • Genomic Mutations
    3 involving Rpl3
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    35 strains or lines available
Homozygous null mice exhibit prenatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    5
  • cDNA Data
    39
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 27367 NCBI Gene Model | MGI Sequence Detail 5561 C57BL/6J ±  kb
transcript NR_177964 RefSeq | MGI Sequence Detail 1476 C57BL/6  
polypeptide P27659 UniProt | EBI | MGI Sequence Detail 403 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000014212 eukaryotic-type large ribosomal subunit protein uL3
    (term hierarchy)
  • PDB
    6SWA, 7CPU, 7CPV, 7LS1, 7LS2
  • InterPro Domains
    IPR000597 Large ribosomal subunit protein uL3
    IPR045077 Large ribosomal subunit protein uL3, archaeal/eukaryotic-type
    IPR019926 Large ribosomal subunit protein uL3, conserved site
    IPR044892 Ribosomal protein L3, domain 3, archaeal-type superfamily
    IPR009000 Translation protein, beta-barrel domain superfamily
  • GlyGen
    P27659 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 41
    cDNA 39
    Primer pair 2

    Microarray probesets 9
References
more
  • Summaries
    All 59
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 7
    Phenotypes 28
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:335523 Shiraishi C, et al., RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function. Nat Commun. 2023 Apr 20;14(1):2131
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory