Defb3 MGI Mouse Gene Detail - MGI:1351612

Symbol

Defb3
Name

defensin beta 3
Synonyms

mBD-3

Feature Type

protein coding gene
IDs

MGI:1351612
NCBI Gene: 27358
Alliance

gene page

Sequence Map

Chr8:19343376-19345307 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 10.35 cM, cytoband A4
Mapping Data

6 experiments

SNPs within 2kb

226 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351612	protein coding gene	Chr8:19343376-19345355 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033419	protein coding gene	Chr8:16767877-16769821 (+)
A/J	MGP_AJ_G0033400	protein coding gene	Chr8:16233930-16235874 (+)
AKR/J	MGP_AKRJ_G0033330	protein coding gene	Chr8:16708355-16710286 (+)
BALB/cJ	MGP_BALBcJ_G0033400	protein coding gene	Chr8:16344234-16346178 (+)
C3H/HeJ	MGP_C3HHeJ_G0033112	protein coding gene	Chr8:16879280-16881224 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033914	protein coding gene	Chr8:17318576-17320507 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0032435	protein coding gene	Chr8:16785361-16787288 (+)
CBA/J	MGP_CBAJ_G0033086	protein coding gene	Chr8:18117337-18119281 (+)
DBA/2J	MGP_DBA2J_G0033240	protein coding gene	Chr8:16147206-16149150 (+)
FVB/NJ	MGP_FVBNJ_G0033188	protein coding gene	Chr8:16163758-16165702 (+)
LP/J	MGP_LPJ_G0033333	protein coding gene	Chr8:16833669-16835600 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033225	protein coding gene	Chr8:18222992-18224936 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033931	protein coding gene	Chr8:16696819-16698750 (+)
PWK/PhJ	MGP_PWKPhJ_G0032148	protein coding gene	Chr8:16367771-16369717 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031989	protein coding gene	Chr8:16620589-16622556 (+)
WSB/EiJ	MGP_WSBEiJ_G0032552	protein coding gene	Chr8:16783116-16785047 (+)

Human Ortholog

DEFB4A, defensin beta 4A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DEFB4A, defensin beta 4A
Synonyms

BD-2, DEFB102, DEFB-2, DEFB2, DEFB4, HBD-2, SAP1
Links

HGNC:2767

NCBI Gene ID: 1673

neXtProt AC: NX_O15263

UniProt: O15263
Chr Location

8p23.1

Human Ortholog

DEFB4B, defensin beta 4B
Synonyms

DEFB4P
Links

HGNC:30193

NCBI Gene ID: 100289462

neXtProt AC: NX_O15263
Chr Location

8

MGI Vertebrate Homology

Defb3 stringent orthology
2 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DEFB4A, DEFB4B
Gene Tree

Defb3

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

3
Targeted

2
Genomic Mutations

1 involving Defb3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibits increased susceptibility to P. aeruginosa- or F. solani-induced keratitis.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

712
Tissues

3
cDNA Data

4
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS40258.1

Ensembl

ENSMUSG00000039775 (Evidence)
NCBI Gene

27358

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039775	Ensembl Gene Model \| MGI Sequence Detail	1932	C57BL/6J	± kb
transcript	ENSMUST00000033852	Ensembl \| MGI Sequence Detail	275	Not Applicable
polypeptide	ENSMUSP00000033852	Ensembl \| MGI Sequence Detail	63	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006806 beta-defensin 3

(term hierarchy)
InterPro Domains

IPR001855 Beta defensin type

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All nucleic 10

Genomic 4

cDNA 4

Primer pair 2

Microarray probesets 2

Summaries

All 37

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 8
Earliest

J:55859 Bals R, et al., Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs. Infect Immun. 1999 Jul;67(7):3542-7
Latest

J:341717 Taylor TC, et al., IkappaBzeta is an essential mediator of immunity to oropharyngeal candidiasis. Cell Host Microbe. 2023 Oct 11;31(10):1700-1713.e4

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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