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Add3 Gene Detail
Summary
  • Symbol
    Add3
  • Name
    adducin 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351615
    NCBI Gene: 27360
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:53128874-53235518 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 47.18 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2840 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351615
 protein coding gene Chr19:53128874-53235830 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025243
 protein coding gene Chr19:53264474-53382592 (+)
A/J MGP_AJ_G0025219
 protein coding gene Chr19:50624171-50734366 (+)
AKR/J MGP_AKRJ_G0025188
 protein coding gene Chr19:52233612-52340027 (+)
BALB/cJ MGP_BALBcJ_G0025214
 protein coding gene Chr19:50713636-50822564 (+)
C3H/HeJ MGP_C3HHeJ_G0024974
 protein coding gene Chr19:52432043-52551730 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025657
 protein coding gene Chr19:54557072-54669595 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023069
 protein coding gene Chr19:49642796-49746715 (+)
CAST/EiJ MGP_CASTEiJ_G0024439
 protein coding gene Chr19:52388461-52504886 (+)
CBA/J MGP_CBAJ_G0024954
 protein coding gene Chr19:57220194-57342885 (+)
DBA/2J MGP_DBA2J_G0025086
 protein coding gene Chr19:50439349-50548812 (+)
FVB/NJ MGP_FVBNJ_G0025047
 protein coding gene Chr19:50149822-50256782 (+)
LP/J MGP_LPJ_G0025172
 protein coding gene Chr19:53120405-53235015 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025078
 protein coding gene Chr19:56699358-56814058 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025715
 protein coding gene Chr19:52410827-52526422 (+)
PWK/PhJ MGP_PWKPhJ_G0024187
 protein coding gene Chr19:50353171-50464005 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023990
 protein coding gene Chr19:51100243-51214149 (+)
WSB/EiJ MGP_WSBEiJ_G0024509
 protein coding gene Chr19:52547866-52662210 (+)



Homology
more
  • Human Ortholog
    ADD3, adducin 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADD3, adducin 3
  • Synonyms
    ADDL, CPSQ3
  • Links
    NCBI Gene ID: 120
    neXtProt AC: NX_Q9UEY8
    UniProt: Q9UEY8

  • Chr Location
    10q25.1-q25.2; chr10:109996368-110135565 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ADD3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    8 phenotype references
Mice homozygous for a knock-out allele exhibit normal blood pressure and show no significant alterations in red blood cell or platelet structure and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    915
  • Tissues
    25
  • cDNA Data
    16
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 27360 NCBI Gene Model | MGI Sequence Detail 106645 C57BL/6J ±  kb
transcript NM_001413986 RefSeq | MGI Sequence Detail 4294 ZRU/MplStud  
polypeptide Q9QYB5 UniProt | EBI | MGI Sequence Detail 706 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 16
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147558, MGI:2147811
References
more
  • Summaries
    All 45
    Developmental Gene Expression 5
    Gene Ontology 11
    Phenotypes 8
  • Earliest
    J:33510 Pinto-Correia C, et al., Immunofluorescence localization of an adducin-like protein in the chromosomes of mouse oocytes. Dev Biol. 1991 Aug;146(2):301-11
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory