Dnajb9 MGI Mouse Gene Detail - MGI:1351618 - DnaJ heat shock protein family (Hsp40) member B9

Symbol

Dnajb9
Name

DnaJ heat shock protein family (Hsp40) member B9
Synonyms

ERdj4, Mdg1, mDj7, microvascular endothelial differentiation gene

Feature Type

protein coding gene
IDs

MGI:1351618
NCBI Gene: 27362
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:44252680-44256851 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 20.71 cM
Mapping Data

3 experiments

SNPs within 2kb

166 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351618	protein coding gene	Chr12:44252342-44257109 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019710	protein coding gene	Chr12:42773071-42777242 (-)
A/J	MGP_AJ_G0019674	protein coding gene	Chr12:41251183-41256563 (-)
AKR/J	MGP_AKRJ_G0019645	protein coding gene	Chr12:42570310-42574481 (-)
BALB/cJ	MGP_BALBcJ_G0019652	protein coding gene	Chr12:41549415-41553594 (-)
C3H/HeJ	MGP_C3HHeJ_G0019456	protein coding gene	Chr12:42537614-42541785 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020099	protein coding gene	Chr12:44041413-44045584 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017724	protein coding gene	Chr12:40268934-40273158 (-)
CAST/EiJ	MGP_CASTEiJ_G0019009	protein coding gene	Chr12:37697451-37701753 (-)
CBA/J	MGP_CBAJ_G0019428	protein coding gene	Chr12:45507129-45511300 (-)
DBA/2J	MGP_DBA2J_G0019541	protein coding gene	Chr12:41137855-41142027 (-)
FVB/NJ	MGP_FVBNJ_G0019530	protein coding gene	Chr12:40662137-40666308 (-)
LP/J	MGP_LPJ_G0019611	protein coding gene	Chr12:42741578-42745749 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019566	protein coding gene	Chr12:46198259-46202650 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020139	protein coding gene	Chr12:42153088-42157259 (-)
PWK/PhJ	MGP_PWKPhJ_G0018776	protein coding gene	Chr12:35806134-35810697 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018566	protein coding gene	Chr12:36752997-36757167 (-)
WSB/EiJ	MGP_WSBEiJ_G0019059	protein coding gene	Chr12:42454388-42460646 (-)

Human Ortholog

DNAJB9, DnaJ heat shock protein family (Hsp40) member B9

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJB9, DnaJ heat shock protein family (Hsp40) member B9
Synonyms

ERdj4, MDG-1, MDG1, MST049, MSTP049
Links

HGNC:6968

NCBI Gene ID: 4189

neXtProt AC: NX_Q9UBS3

UniProt: Q9UBS3
Chr Location

7q31; chr7:108569867-108574850 (+) GRCh38

MGI Vertebrate Homology

Dnajb9 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DNAJB9
Gene Tree

Dnajb9

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Phenotype Summary

21 phenotypes from 1 allele in 3 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a hypomorphic allele show perinatal death, reduced birth size and liver glycogen levels, and hypoglycemia. Surviving adults show elevated ER stress in MEFs, lung, kidney, salivary gland and in pancreas, associated with beta cell loss, hypoinsulinemia, and glucose intolerance.

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All GO Annotations

22
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

807
Tissues

97
cDNA Data

14
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnajb9

ZFIN dnajb9b

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All Sequences

45
RefSeq

2
UniProt

2
CCDS

CCDS25897.1

Ensembl

ENSMUSG00000014905 (Evidence)
NCBI Gene

27362

			Length	Strain/Species	Flank
genomic	27362	NCBI Gene Model \| MGI Sequence Detail	4172	C57BL/6J	± kb
transcript	NM_013760	RefSeq \| MGI Sequence Detail	1865	C57BL/6
polypeptide	Q9QYI6	UniProt \| EBI \| MGI Sequence Detail	222	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006578 DnaJ homolog subfamily B member 9

(term hierarchy)
InterPro Domains

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR018253 DnaJ domain, conserved site

IPR051948 Hsp70 co-chaperone J-domain-containing protein

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All nucleic 18

cDNA 15

Primer pair 2

Other 1

Microarray probesets 4

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MGI:2144721, MGI:2144746, MGI:2144747, MGI:2145046

Summaries

All 48

Developmental Gene Expression 6

Gene Ontology 9

Phenotypes 9
Earliest

J:67228 Ohtsuka K, et al., Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. Cell Stress Chaperones. 2000 Apr;5(2):98-112
Latest

J:344311 Yan W, et al., Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy. Commun Biol. 2024 Jan 13;7(1):94

TSS for Dnajb9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116195	Chr12:44257161-44257171 (-)	-315 bp
Tssr116194	Chr12:44256961-44256968 (-)	-114 bp
Tssr116193	Chr12:44256897-44256910 (-)	-53 bp
Tssr116192	Chr12:44256878-44256887 (-)	-32 bp
Tssr116191	Chr12:44256844-44256860 (-)	-1 bp
Tssr116190	Chr12:44253860-44253867 (-)	2,987 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24