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Abcg3 Gene Detail
Summary
  • Symbol
    Abcg3
  • Name
    ATP binding cassette subfamily G member 3
  • Synonyms
    Abcp2, Mxr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351624
    NCBI Gene: 27405
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:105082923-105130584 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 50.68 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1109 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351624
 protein coding gene Chr5:105082923-105130675 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029818
 protein coding gene Chr5:106695246-106754432 (-)
A/J MGP_AJ_G0029782
 protein coding gene Chr5:102535482-102584994 (-)
AKR/J MGP_AKRJ_G0029730
 protein coding gene Chr5:106017694-106069287 (-)
BALB/cJ MGP_BALBcJ_G0029795
 protein coding gene Chr5:103775367-103825686 (-)
C3H/HeJ MGP_C3HHeJ_G0029516
 protein coding gene Chr5:106409789-106459767 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030249
 protein coding gene Chr5:111085568-111143920 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027483
 protein coding gene Chr5:97824270-97896880 (-)
CAST/EiJ MGP_CASTEiJ_G0028928
 protein coding gene Chr5:105254596-105316002 (-)
CBA/J MGP_CBAJ_G0029487
 protein coding gene Chr5:114962240-115018734 (-)
DBA/2J MGP_DBA2J_G0029631
 protein coding gene Chr5:102854562-102905297 (-)
FVB/NJ MGP_FVBNJ_G0029589
 protein coding gene Chr5:101606657-101652613 (-)
LP/J MGP_LPJ_G0029719
 protein coding gene Chr5:107365779-107413764 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029619
 protein coding gene Chr5:119890957-119941826 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030283
 protein coding gene Chr5:105503820-105551714 (-)
PWK/PhJ MGP_PWKPhJ_G0028644
 protein coding gene Chr5:101266926-101320335 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028481
 protein coding gene Chr5:103072524-103122672 (-)
WSB/EiJ MGP_WSBEiJ_G0029006
 protein coding gene Chr5:105861178-105913855 (-)



Homology
more
  • Human Ortholog
    ABCG2, ATP binding cassette subfamily G member 2 (JR blood group)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCG2, ATP binding cassette subfamily G member 2 (JR blood group)
  • Synonyms
    ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, CDw388, EST157481, GOUT1, MRX, MXR, MXR-1, MXR1, UAQTL1
  • Links
    NCBI Gene ID: 9429
    neXtProt AC: NX_Q9UNQ0
    UniProt: Q9UNQ0

  • Chr Location
    4q22.1; chr4:88090150-88231628 (-)  GRCh38
Human Diseases
more
  • Diseases
    6 with human ABCG2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    26
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    13
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029299 Ensembl Gene Model | MGI Sequence Detail 47662 C57BL/6J ±  kb
transcript ENSMUST00000031239 Ensembl | MGI Sequence Detail 3035 Not Applicable  
polypeptide ENSMUSP00000031239 Ensembl | MGI Sequence Detail 650 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000033932 ATP-binding cassette sub-family G member 3
    (term hierarchy)
  • InterPro Domains
    IPR013525 ABC-2 type transporter, transmembrane domain
    IPR043926 ABC transporter family G domain
    IPR003439 ABC transporter-like, ATP-binding domain
    IPR050352 ATP-binding cassette subfamily G transporters
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 4
References
more
  • Summaries
    All 38
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory