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Pdhx Gene Detail
Summary
  • Symbol
    Pdhx
  • Name
    pyruvate dehydrogenase complex, component X
  • Synonyms
    Pdx1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351627
    NCBI Gene: 27402
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:102851420-102903858 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 54.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    385 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351627
protein coding gene Chr2:102851400-102903858 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026200
protein coding gene Chr2:104971575-105027773 (-)
A/J MGP_AJ_G0026161
protein coding gene Chr2:100653736-100707839 (-)
AKR/J MGP_AKRJ_G0026142
protein coding gene Chr2:103378117-103430384 (-)
BALB/cJ MGP_BALBcJ_G0026170
protein coding gene Chr2:100934246-100987214 (-)
C3H/HeJ MGP_C3HHeJ_G0025921
protein coding gene Chr2:103743510-103796537 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026621
protein coding gene Chr2:108522506-108575848 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024012
protein coding gene Chr2:96315061-96373975 (-)
CAST/EiJ MGP_CASTEiJ_G0025386
protein coding gene Chr2:104184974-104242026 (-)
CBA/J MGP_CBAJ_G0025899
protein coding gene Chr2:112225515-112279875 (-)
DBA/2J MGP_DBA2J_G0026035
protein coding gene Chr2:100219135-100272245 (-)
FVB/NJ MGP_FVBNJ_G0025998
protein coding gene Chr2:99218052-99272910 (-)
LP/J MGP_LPJ_G0026139
protein coding gene Chr2:105119732-105174561 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026024
protein coding gene Chr2:116158077-116210357 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026675
protein coding gene Chr2:103593989-103646274 (-)
PWK/PhJ MGP_PWKPhJ_G0025121
protein coding gene Chr2:99715543-99768403 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024922
protein coding gene Chr2:102814936-102868714 (-)
WSB/EiJ MGP_WSBEiJ_G0025453
protein coding gene Chr2:104298144-104351115 (-)



Homology
more
  • Human Ortholog
    PDHX, pyruvate dehydrogenase complex component X
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDHX, pyruvate dehydrogenase complex component X
  • Synonyms
    DLDBP, E3BP, OPDX, PDHXD, PDX1, proX
  • Links
    NCBI Gene ID: 8050
    neXtProt AC: NX_O00330
    UniProt: O00330

  • Chr Location
    11p13; chr11:34915829-35020591 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human PDHX associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000010914 Ensembl Gene Model | MGI Sequence Detail 52439 C57BL/6J ±  kb
    transcript ENSMUST00000011058 Ensembl | MGI Sequence Detail 2506 Not Applicable  
    polypeptide ENSMUSP00000011058 Ensembl | MGI Sequence Detail 501 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012496 pyruvate dehydrogenase protein X component, mitochondrial
    • InterPro Domains
      IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
      IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
      IPR000089 Biotin/lipoyl attachment
      IPR023213 Chloramphenicol acetyltransferase-like domain superfamily
      IPR045257 Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component
      IPR036625 E3-binding domain superfamily
      IPR004167 Peripheral subunit-binding domain
      IPR011053 Single hybrid motif
    • GlyGen
      Q8BKZ9 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 52

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138985
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 9
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/12/2024
    MGI 6.24
    The Jackson Laboratory