Rps26 MGI Mouse Gene Detail - MGI:1351628

Symbol

Rps26
Name

ribosomal protein S26

Feature Type

protein coding gene
IDs

MGI:1351628
NCBI Gene: 27370
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:128460398-128462375 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 77.11 cM
Mapping Data

2 experiments

SNPs within 2kb

185 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351628	protein coding gene	Chr10:128460398-128462616 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017874	protein coding gene	Chr10:132383084-132385060 (-)
A/J	MGP_AJ_G0017849	protein coding gene	Chr10:127066565-127074045 (-)
AKR/J	MGP_AKRJ_G0017812	protein coding gene	Chr10:130784895-130786985 (-)
BALB/cJ	MGP_BALBcJ_G0017813	protein coding gene	Chr10:127439654-127441630 (-)
C3H/HeJ	MGP_C3HHeJ_G0017636	protein coding gene	Chr10:130950889-130953694 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018268	protein coding gene	Chr10:136862062-136864085 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015946	protein coding gene	Chr10:120987602-120989348 (-)
CAST/EiJ	MGP_CASTEiJ_G0017197	protein coding gene	Chr10:131673214-131677103 (-)
CBA/J	MGP_CBAJ_G0017606	protein coding gene	Chr10:142436861-142441041 (-)
DBA/2J	MGP_DBA2J_G0017712	protein coding gene	Chr10:126117417-126125234 (-)
FVB/NJ	MGP_FVBNJ_G0017707	protein coding gene	Chr10:125047173-125049149 (-)
LP/J	MGP_LPJ_G0017786	protein coding gene	Chr10:132980123-132982100 (-)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0018308	protein coding gene	Chr10:130889279-130891255 (-)
PWK/PhJ	MGP_PWKPhJ_G0016982	protein coding gene	Chr10:126387073-126389164 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016771	protein coding gene	Chr10:130003368-130006176 (-)
WSB/EiJ	MGP_WSBEiJ_G0017256	protein coding gene	Chr10:131110781-131112758 (-)

Human Ortholog

RPS26, ribosomal protein S26

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPS26, ribosomal protein S26
Synonyms

DBA10, eS26, S26
Links

HGNC:10414

NCBI Gene ID: 6231

neXtProt AC: NX_P62854

UniProt: P62854
Chr Location

12q13.2; chr12:56041351-56044697 (+) GRCh38

MGI Vertebrate Homology

Rps26 stringent orthology
1 human;1 mouse;3 rat;2 zebrafish
HCOP

vertebrate homology predictions: RPS26
Gene Tree

Rps26

Diseases

1 with human RPS26 associations

				Human Disease	Mouse Models
				Diamond-Blackfan anemia 10 IDs Diamond-Blackfan anemia 10 DOID:0111888 MESH:C567649 OMIM:613309

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 2 alleles in 3 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

55
Endonuclease-mediated

1
Gene trapped

50
Targeted

4
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Knockout in mouse oocytes results in arrested follicle development from pre-antral follicles to antral follicles and all oocytes die by P84 resulting in premature ovarian failure.

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All GO Annotations

28
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

6
cDNA Data

16
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rps26

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All Sequences

45
RefSeq

2
UniProt

2
CCDS

CCDS36090.1

Ensembl

ENSMUSG00000025362 (Evidence)
NCBI Gene

27370

			Length	Strain/Species	Flank
genomic	27370	NCBI Gene Model \| MGI Sequence Detail	1978	C57BL/6J	± kb
transcript	NM_013765	RefSeq \| MGI Sequence Detail	457	C57BL/6
polypeptide	P62855	UniProt \| EBI \| MGI Sequence Detail	115	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014269 small ribosomal subunit protein eS26

(term hierarchy)
PDB

7CPU, 7CPV, 7LS1, 7LS2
InterPro Domains

IPR047864 Ribosomal protein eS26, conserved site

IPR038551 Ribosomal protein eS26 superfamily

IPR000892 Small ribosomal subunit protein eS26
GlyGen

P62855 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 18

cDNA 16

Primer pair 2

Microarray probesets 4

Summaries

All 40

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rps26:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99913	Chr10:128462620-128462636 (-)	-253 bp
Tssr99912	Chr10:128462592-128462609 (-)	-226 bp
Tssr99911	Chr10:128462565-128462584 (-)	-200 bp
Tssr99910	Chr10:128462541-128462558 (-)	-175 bp
Tssr99909	Chr10:128462423-128462425 (-)	-49 bp
Tssr99908	Chr10:128462401-128462406 (-)	-29 bp
Tssr99907	Chr10:128462333-128462389 (-)	14 bp
Tssr99906	Chr10:128462322-128462327 (-)	50 bp
Tssr99905	Chr10:128462290-128462312 (-)	74 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24