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Srr Gene Detail
Summary
  • Symbol
    Srr
  • Name
    serine racemase
  • Synonyms
    M100034, Rgsc34
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351636
    NCBI Gene: 27364
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:74797185-74816774 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.76 cM, cytoband B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    447 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351636
 protein coding gene Chr11:74794853-74818427 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018702
 protein coding gene Chr11:75622096-75642761 (-)
A/J MGP_AJ_G0018668
 protein coding gene Chr11:72815134-72834662 (-)
AKR/J MGP_AKRJ_G0018638
 protein coding gene Chr11:75024294-75043863 (-)
BALB/cJ MGP_BALBcJ_G0018642
 protein coding gene Chr11:73183547-73203331 (-)
C3H/HeJ MGP_C3HHeJ_G0018455
 protein coding gene Chr11:75028143-75048726 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019093
 protein coding gene Chr11:77997623-78018572 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016728
 protein coding gene Chr11:69840461-69858112 (-)
CAST/EiJ MGP_CASTEiJ_G0018009
 protein coding gene Chr11:75411336-75439230 (-)
CBA/J MGP_CBAJ_G0018425
 protein coding gene Chr11:81421114-81444916 (-)
DBA/2J MGP_DBA2J_G0018534
 protein coding gene Chr11:72415279-72434659 (-)
FVB/NJ MGP_FVBNJ_G0018524
 protein coding gene Chr11:71986936-72006388 (-)
LP/J MGP_LPJ_G0018605
 protein coding gene Chr11:76214784-76234353 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018550
 protein coding gene Chr11:82022224-82042929 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019133
 protein coding gene Chr11:75213094-75233780 (-)
PWK/PhJ MGP_PWKPhJ_G0017780
 protein coding gene Chr11:73113411-73133945 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017571
 protein coding gene Chr11:74788168-74812009 (-)
WSB/EiJ MGP_WSBEiJ_G0018062
 protein coding gene Chr11:75022879-75044836 (-)



Homology
more
  • Human Ortholog
    SRR, serine racemase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRR, serine racemase
  • Synonyms
    ILV1, ISO1
  • Links
    NCBI Gene ID: 63826
    neXtProt AC: NX_Q9GZT4
    UniProt: Q9GZT4

  • Chr Location
    17p13.3; chr17:2303378-2325264 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Srr mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 4 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased D-serine levels in the cerebral cortex and hippocampus, and neuronal damage associated with NMDA excitotoxicity and beta-amyloid peptide 1-42 exposure is decreased.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    814
  • Tissues
    100
  • cDNA Data
    22
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001323 Ensembl Gene Model | MGI Sequence Detail 19590 C57BL/6J ±  kb
    transcript ENSMUST00000108448 Ensembl | MGI Sequence Detail 3239 Not Applicable  
    polypeptide ENSMUSP00000104087 Ensembl | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 24

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:3798494
    References
    more
    • Summaries
      All 116
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 13
      Phenotypes 70
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:355705 Barragan EV, et al., d-Serine Inhibits Non-ionotropic NMDA Receptor Signaling. J Neurosci. 2024 Aug 7;44(32)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory