Fam50b MGI Mouse Gene Detail - MGI:1351640 - family with sequence similarity 50, member B

Symbol

Fam50b
Name

family with sequence similarity 50, member B
Synonyms

D0H6S2654E, X5L, XAP-5-like

Feature Type

protein coding gene
IDs

MGI:1351640
NCBI Gene: 108161
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:34918833-34931605 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 14.18 cM
Mapping Data

1 experiment

SNPs within 2kb

437 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351640	protein coding gene	Chr13:34918833-34931606 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020452	protein coding gene	Chr13:32862785-32878695 (+)
A/J	MGP_AJ_G0020406	protein coding gene	Chr13:31878862-31891625 (+)
AKR/J	MGP_AKRJ_G0020384	protein coding gene	Chr13:32644129-32656937 (+)
BALB/cJ	MGP_BALBcJ_G0020402	protein coding gene	Chr13:31952374-31965489 (+)
C3H/HeJ	MGP_C3HHeJ_G0020201	protein coding gene	Chr13:32577218-32589960 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020835	protein coding gene	Chr13:33927411-33940115 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018422	protein coding gene	Chr13:30190800-30203315 (+)
CAST/EiJ	MGP_CASTEiJ_G0019716	protein coding gene	Chr13:32246533-32261834 (+)
CBA/J	MGP_CBAJ_G0020162	protein coding gene	Chr13:35411128-35424009 (+)
DBA/2J	MGP_DBA2J_G0020284	protein coding gene	Chr13:31420817-31434096 (+)
FVB/NJ	MGP_FVBNJ_G0020263	protein coding gene	Chr13:30983864-30996456 (+)
LP/J	MGP_LPJ_G0020359	protein coding gene	Chr13:33095528-33108256 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020293	protein coding gene	Chr13:35608042-35620724 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020878	protein coding gene	Chr13:32296519-32309269 (+)
PWK/PhJ	MGP_PWKPhJ_G0019471	protein coding gene	Chr13:31551067-31563905 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019298	protein coding gene	Chr13:30938695-30952548 (+)
WSB/EiJ	MGP_WSBEiJ_G0019778	protein coding gene	Chr13:32658556-32674115 (+)

Human Ortholog

FAM50B, family with sequence similarity 50 member B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM50B, family with sequence similarity 50 member B
Synonyms

D6S2654E, X5L
Links

HGNC:18789

NCBI Gene ID: 26240

neXtProt AC: NX_Q9Y247

UniProt: Q9Y247
Chr Location

6p25.2; chr6:3831894-3851320 (+) GRCh38

MGI Vertebrate Homology

Fam50b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAM50B
Gene Tree

Fam50b

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Fam50b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout leads to male infertility owing to impaired sperm motility caused by flagellum dysmorphologies.

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

8
cDNA Data

6
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

35
RefSeq

4
UniProt

1
CCDS

CCDS49232.1

Ensembl

ENSMUSG00000038246 (Evidence)
NCBI Gene

108161

			Length	Strain/Species	Flank
genomic	108161	NCBI Gene Model \| MGI Sequence Detail	12773	C57BL/6J	± kb
transcript	NM_138746	RefSeq \| MGI Sequence Detail	1315	C57BL/6
polypeptide	Q9WTJ8	UniProt \| EBI \| MGI Sequence Detail	334	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032469 protein FAM50B

(term hierarchy)
InterPro Domains

IPR048337 FAM50A/XAP5, C-terminal domain

IPR007005 XAP5 protein

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All nucleic 6

cDNA 6

Microarray probesets 3

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 13
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:357849 Wang W, et al., Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors. Elife. 2024;

TSS for Fam50b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119224	Chr13:34918820-34918845 (+)	0 bp
Tssr119225	Chr13:34918854-34918865 (+)	27 bp
Tssr119226	Chr13:34923590-34923619 (+)	4,772 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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