Abca7 MGI Mouse Gene Detail - MGI:1351646 - ATP-binding cassette, sub-family A member 7

Symbol

Abca7
Name

ATP-binding cassette, sub-family A member 7
Synonyms

Abc51

Feature Type

protein coding gene
IDs

MGI:1351646
NCBI Gene: 27403
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:79832328-79851406 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

7 experiments

SNPs within 2kb

463 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351646	protein coding gene	Chr10:79832328-79851406 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017477	protein coding gene	Chr10:80569412-80588489 (+)
A/J	MGP_AJ_G0017455	protein coding gene	Chr10:77752491-77772653 (+)
AKR/J	MGP_AKRJ_G0017416	protein coding gene	Chr10:79871529-79890606 (+)
BALB/cJ	MGP_BALBcJ_G0017417	protein coding gene	Chr10:77980075-77999153 (+)
C3H/HeJ	MGP_C3HHeJ_G0017240	protein coding gene	Chr10:79977303-79996381 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017871	protein coding gene	Chr10:83353571-83372640 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015559	protein coding gene	Chr10:73978450-73997375 (+)
CAST/EiJ	MGP_CASTEiJ_G0016807	protein coding gene	Chr10:80175720-80194797 (+)
CBA/J	MGP_CBAJ_G0017212	protein coding gene	Chr10:86580330-86599411 (+)
DBA/2J	MGP_DBA2J_G0017318	protein coding gene	Chr10:76969393-76988450 (+)
FVB/NJ	MGP_FVBNJ_G0017312	protein coding gene	Chr10:76148623-76167692 (+)
LP/J	MGP_LPJ_G0017389	protein coding gene	Chr10:81046663-81065753 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017338	protein coding gene	Chr10:88541640-88560772 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017912	protein coding gene	Chr10:79859489-79878565 (+)
PWK/PhJ	MGP_PWKPhJ_G0016588	protein coding gene	Chr10:76835772-76855032 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016377	protein coding gene	Chr10:78832743-78851846 (+)
WSB/EiJ	MGP_WSBEiJ_G0016867	protein coding gene	Chr10:79885001-79904080 (+)

Human Ortholog

ABCA7, ATP binding cassette subfamily A member 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ABCA7, ATP binding cassette subfamily A member 7
Synonyms

ABCA-SSN, ABCX, AD9
Links

HGNC:37

NCBI Gene ID: 10347

neXtProt AC: NX_Q8IZY2

UniProt: Q8IZY2
Chr Location

19p13.3; chr19:1039997-1065572 (+) GRCh38

MGI Vertebrate Homology

Abca7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ABCA7
Gene Tree

Abca7

Diseases

1 with human ABCA7 associations

				Human Disease	Mouse Models
				Alzheimer's disease 9 IDs Alzheimer's disease 9 DOID:0111364 OMIM:608907

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

9
Gene trapped

4
Targeted

5
Genomic Mutations

1 involving Abca7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

91 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant females, but not males, have less white fat and lower total serum and HDL cholesterol levels. Males exhibit a 10% reduction in kidney size.

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All GO Annotations

68
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

838
Tissues

125
cDNA Data

10
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

53
RefSeq

7
UniProt

5
CCDS

CCDS24004.1, CCDS83724.1

Ensembl

ENSMUSG00000035722 (Evidence)
NCBI Gene

27403

			Length	Strain/Species	Flank
genomic	27403	NCBI Gene Model \| MGI Sequence Detail	19079	C57BL/6J	± kb
transcript	NM_001347081	RefSeq \| MGI Sequence Detail	6720	ZRU/MplStud
polypeptide	Q91V24	UniProt \| EBI \| MGI Sequence Detail	2159	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000003545 phospholipid-transporting ATPase ABCA7

(term hierarchy)
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR013525 ABC-2 type transporter, transmembrane domain

IPR026082 ABC transporter A

IPR003439 ABC transporter-like, ATP-binding domain

IPR017871 ABC transporter-like, conserved site

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q91V24 6 sites, 10 N-linked glycans (6 sites)

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All nucleic 12

Genomic 1

cDNA 10

Primer pair 1

Microarray probesets 4

Summaries

All 72

Developmental Gene Expression 6

Gene Ontology 16

Phenotypes 32
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:351573 Sasner M, et al., In vivo validation of late-onset Alzheimer's disease genetic risk factors. Alzheimers Dement. 2024 Jul;20(7):4970-4984

TSS for Abca7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94446	Chr10:79830679-79830692 (+)	-1,642 bp
Tssr94447	Chr10:79830852-79830869 (+)	-1,467 bp
Tssr94448	Chr10:79830912-79830924 (+)	-1,410 bp
Tssr94449	Chr10:79831092-79831136 (+)	-1,214 bp
Tssr94450	Chr10:79832289-79832309 (+)	-29 bp
Tssr94451	Chr10:79832313-79832339 (+)	-2 bp
Tssr94452	Chr10:79832349-79832358 (+)	26 bp
Tssr94453	Chr10:79832376-79832385 (+)	53 bp
Tssr94454	Chr10:79833297-79833335 (+)	988 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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