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Prl3c1 Gene Detail
Summary
  • Symbol
    Prl3c1
  • Name
    prolactin family 3, subfamily c, member 1
  • Synonyms
    PLP I, PLP-J, Prlpj
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351649
    NCBI Gene: 27372
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:27380643-27387732 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 12.32 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    223 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351649
 protein coding gene Chr13:27380642-27387732 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020392
 protein coding gene Chr13:24815299-24822291 (+)
A/J MGP_AJ_G0020343
 protein coding gene Chr13:24285379-24292346 (+)
AKR/J MGP_AKRJ_G0020323
 protein coding gene Chr13:24623944-24630815 (+)
BALB/cJ MGP_BALBcJ_G0020341
 protein coding gene Chr13:24286233-24293598 (+)
C3H/HeJ MGP_C3HHeJ_G0020144
 protein coding gene Chr13:24688085-24695052 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020778
 protein coding gene Chr13:25681975-25688942 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018363
 protein coding gene Chr13:22918659-22926302 (+)
CAST/EiJ MGP_CASTEiJ_G0019662
 protein coding gene Chr13:24374833-24385806 (+)
CBA/J MGP_CBAJ_G0020098
 protein coding gene Chr13:26747227-26756875 (+)
DBA/2J MGP_DBA2J_G0020222
 protein coding gene Chr13:23816310-23823958 (+)
FVB/NJ MGP_FVBNJ_G0020208
 protein coding gene Chr13:23426614-23434028 (+)
LP/J MGP_LPJ_G0020298
 protein coding gene Chr13:25080131-25088760 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020236
 protein coding gene Chr13:26996160-27000419 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020818
 protein coding gene Chr13:24466200-24474231 (+)
PWK/PhJ MGP_PWKPhJ_G0019416
 protein coding gene Chr13:23728378-23735618 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019232
 protein coding gene Chr13:23376559-23384034 (+)
WSB/EiJ MGP_WSBEiJ_G0019722
 protein coding gene Chr13:24641804-24648788 (+)



Homology
less
Human Diseases
more
  • Diseases
    1 with Prl3c1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced female fertility and a male reproductive tract phenotype that includes enlarged testes and seminal vesicles, increased sperm count, increased serum testosterone and luteinizing hormone levels, and abnormal adult Leydig cell differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    14
  • cDNA Data
    6
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27372 NCBI Gene Model | MGI Sequence Detail 7090 C57BL/6J ±  kb
    transcript NM_001163218 RefSeq | MGI Sequence Detail 865 ZRU/MplStud  
    polypeptide Q9QUN5 UniProt | EBI | MGI Sequence Detail 212 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 8
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1861442
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:324161 Tang S, et al., BMP/SMAD1/5 Signaling in the Endometrial Epithelium Is Essential for Receptivity and Early Pregnancy. Endocrinology. 2022 May 1;163(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory