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Akr1c13 Gene Detail
Summary
  • Symbol
    Akr1c13
  • Name
    aldo-keto reductase family 1, member C13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351662
    NCBI Gene: 27384
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:4241167-4255601 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 2.34 cM, cytoband A1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    496 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351662
 protein coding gene Chr13:4241149-4255601 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020204
 protein coding gene Chr13:682134-696525 (+)
A/J MGP_AJ_G0020160
 protein coding gene Chr13:775943-791555 (+)
AKR/J MGP_AKRJ_G0020135
 protein coding gene Chr13:790515-804947 (+)
BALB/cJ MGP_BALBcJ_G0020143
 protein coding gene Chr13:768552-787786 (+)
C3H/HeJ MGP_C3HHeJ_G0019947
 protein coding gene Chr13:856749-871236 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020590
 protein coding gene Chr13:753435-772666 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018202
 protein coding gene Chr13:663121-674332 (+)
CAST/EiJ MGP_CASTEiJ_G0019487
 protein coding gene Chr13:695465-710055 (+)
CBA/J MGP_CBAJ_G0019914
 protein coding gene Chr13:760201-778450 (+)
DBA/2J MGP_DBA2J_G0020031
 protein coding gene Chr13:688581-703515 (+)
FVB/NJ MGP_FVBNJ_G0020016
 protein coding gene Chr13:656261-669660 (+)
LP/J MGP_LPJ_G0020105
 protein coding gene Chr13:754428-767668 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020052
 protein coding gene Chr13:820870-838289 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020618
 protein coding gene Chr13:748668-763152 (+)
PWK/PhJ MGP_PWKPhJ_G0019250
 protein coding gene Chr13:833623-844286 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019054
 protein coding gene Chr13:784976-803506 (+)
WSB/EiJ MGP_WSBEiJ_G0019545
 protein coding gene Chr13:693080-707835 (+)



Homology
more
  • Human Ortholog
    AKR1C4, aldo-keto reductase family 1 member C4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKR1C4, aldo-keto reductase family 1 member C4
  • Synonyms
    3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA
  • Links
    NCBI Gene ID: 1109
    neXtProt AC: NX_P17516
    UniProt: P17516

  • Chr Location
    10p15.1; chr10:5195462-5218949 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human AKR1C2,AKR1C3,AKR1C4 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    9
  • cDNA Data
    4
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 27384 NCBI Gene Model | MGI Sequence Detail 14435 C57BL/6J ±  kb
transcript NM_001426627 RefSeq | MGI Sequence Detail 1391 C57BL/6  
polypeptide Q8VC28 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 4
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:58090 Ikeda S, et al., Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach. FEBS Lett. 1999 Oct 15;459(3):433-7
  • Latest
    J:306135 Shimizu R, et al., Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models. Biochem Biophys Res Commun. 2021 Jan 8;535:87-92
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory