Ptdss2 MGI Mouse Gene Detail - MGI:1351664 - phosphatidylserine synthase 2

Symbol

Ptdss2
Name

phosphatidylserine synthase 2
Synonyms

PSS2

Feature Type

protein coding gene
IDs

MGI:1351664
NCBI Gene: 27388
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:140711181-140736071 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 86.39 cM
Mapping Data

2 experiments

SNPs within 2kb

622 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351664	protein coding gene	Chr7:140702295-140737519 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033212	protein coding gene	Chr7:146293667-146329975 (+)
A/J	MGP_AJ_G0033194	protein coding gene	Chr7:142111468-142147999 (+)
AKR/J	MGP_AKRJ_G0033126	protein coding gene	Chr7:146027656-146062378 (+)
BALB/cJ	MGP_BALBcJ_G0033195	protein coding gene	Chr7:141853013-141888315 (+)
C3H/HeJ	MGP_C3HHeJ_G0032909	protein coding gene	Chr7:145778533-145818298 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033706	protein coding gene	Chr7:151644585-151681568 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030679	protein coding gene	Chr7:143322579-143356696 (+)
CAST/EiJ	MGP_CASTEiJ_G0032239	protein coding gene	Chr7:138089432-138123163 (+)
CBA/J	MGP_CBAJ_G0032881	protein coding gene	Chr7:156753720-156788191 (+)
DBA/2J	MGP_DBA2J_G0033033	protein coding gene	Chr7:140060828-140095389 (+)
FVB/NJ	MGP_FVBNJ_G0032986	protein coding gene	Chr7:139964248-140003195 (+)
LP/J	MGP_LPJ_G0033128	protein coding gene	Chr7:147783485-147821246 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033019	protein coding gene	Chr7:157437926-157474024 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033726	protein coding gene	Chr7:145007415-145043979 (+)
PWK/PhJ	MGP_PWKPhJ_G0031943	protein coding gene	Chr7:133337740-133373071 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031790	protein coding gene	Chr7:131820366-131859230 (+)
WSB/EiJ	MGP_WSBEiJ_G0032350	protein coding gene	Chr7:145953561-145990999 (+)

Human Ortholog

PTDSS2, phosphatidylserine synthase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTDSS2, phosphatidylserine synthase 2
Synonyms

PSS2
Links

HGNC:15463

NCBI Gene ID: 81490

neXtProt AC: NX_Q9BVG9

UniProt: Q9BVG9
Chr Location

11p15.5; chr11:448268-491399 (+) GRCh38

MGI Vertebrate Homology

Ptdss2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PTDSS2
Gene Tree

Ptdss2

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

85
Endonuclease-mediated

2
Gene trapped

79
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Ptdss2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

74 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Disruption of this gene causes infertility in about 10% of homozygous males. The remaining males and all females were fertile.

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

857
Tissues

115
cDNA Data

22
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptdss2

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All Sequences

86
RefSeq

20
UniProt

5
CCDS

CCDS22001.1

Ensembl

ENSMUSG00000025495 (Evidence)
NCBI Gene

27388

			Length	Strain/Species	Flank
genomic	27388	NCBI Gene Model \| MGI Sequence Detail	24891	C57BL/6J	± kb
transcript	NR_184743	RefSeq \| MGI Sequence Detail	2179	C57BL/6
polypeptide	Q9Z1X2	UniProt \| EBI \| MGI Sequence Detail	473	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013416 phosphatidylserine synthase 2

(term hierarchy)
EC

2.7.8.29
InterPro Domains

IPR004277 Phosphatidyl serine synthase
GlyGen

Q9Z1X2 1 site, 1 N-linked glycan (1 site)

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All nucleic 23

cDNA 22

Primer pair 1

Microarray probesets 11

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MGI:2141985, MGI:2142082

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 19
Earliest

J:57025 Stone SJ, et al., Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2. Biochem J. 1999 Aug 15;342(Pt 1):57-64
Latest

J:190989 Kimura AK, et al., Phosphatidylserine synthase 2: high efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid. J Lipid Res. 2013 Jan;54(1):214-22

TSS for Ptdss2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69916	Chr7:140711181-140711246 (+)	33 bp
Tssr69917	Chr7:140711254-140711291 (+)	92 bp
Tssr69918	Chr7:140712346-140712363 (+)	1,174 bp
Tssr69919	Chr7:140712371-140712389 (+)	1,199 bp
Tssr69920	Chr7:140712391-140712414 (+)	1,222 bp
Tssr69921	Chr7:140725040-140725043 (+)	13,861 bp
Tssr69922	Chr7:140728864-140728890 (+)	17,696 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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