Slco1a5 MGI Mouse Gene Detail - MGI:1351865 - solute carrier organic anion transporter family, member 1a5

Symbol

Slco1a5
Name

solute carrier organic anion transporter family, member 1a5
Synonyms

Oatp3, Slc21a7

Feature Type

protein coding gene
IDs

MGI:1351865
NCBI Gene: 108096
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr6:142179953-142268707 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 73.69 cM
Mapping Data

2 experiments

SNPs within 2kb

2840 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351865	protein coding gene	Chr6:142179953-142268707 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031459	protein coding gene	Chr6:147023022-147111314 (-)
A/J	MGP_AJ_G0031434	protein coding gene	Chr6:141239169-141330356 (-)
AKR/J	MGP_AKRJ_G0031362	protein coding gene	Chr6:145439435-145529680 (-)
BALB/cJ	MGP_BALBcJ_G0031441	protein coding gene	Chr6:141020069-141105902 (-)
C3H/HeJ	MGP_C3HHeJ_G0031163	protein coding gene	Chr6:145485420-145575998 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031903	protein coding gene	Chr6:151053055-151153924 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029027	protein coding gene	Chr6:140089528-140171941 (-)
CAST/EiJ	MGP_CASTEiJ_G0030531	protein coding gene	Chr6:145047016-145142626 (-)
CBA/J	MGP_CBAJ_G0031123	protein coding gene	Chr6:156776810-156887984 (-)
DBA/2J	MGP_DBA2J_G0031280	protein coding gene	Chr6:140050862-140141941 (-)
FVB/NJ	MGP_FVBNJ_G0031231	protein coding gene	Chr6:138820744-138910190 (-)
LP/J	MGP_LPJ_G0031364	protein coding gene	Chr6:147154158-147248971 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031271	protein coding gene	Chr6:160688714-160787172 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031935	protein coding gene	Chr6:145264314-145357133 (-)
PWK/PhJ	MGP_PWKPhJ_G0030258	protein coding gene	Chr6:138546547-138638928 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030082	protein coding gene	Chr6:143464492-143550898 (-)
WSB/EiJ	MGP_WSBEiJ_G0030624	protein coding gene	Chr6:145898468-145990232 (-)

Human Ortholog

SLCO1A2, solute carrier organic anion transporter family member 1A2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLCO1A2, solute carrier organic anion transporter family member 1A2
Synonyms

OATP, OATP1A2, OATP-A, SLC21A3
Links

HGNC:10956

NCBI Gene ID: 6579

neXtProt AC: NX_P46721

UniProt: P46721
Chr Location

12p12.1; chr12:21264600-21419634 (-) GRCh38

MGI Vertebrate Homology

Slco1a5 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SLCO1A2
Gene Tree

Slco1a5

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Genomic Mutations

1 involving Slco1a5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

56 strains or lines available

Homozygous mutation of this gene results in decreased percentage of CD8 ells and increased percentage of B cells in the peripheral blood.

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All GO Annotations

28
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

859
Tissues

101
cDNA Data

20
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

43
RefSeq

4
UniProt

5
CCDS

CCDS57464.1

Ensembl

ENSMUSG00000063975 (Evidence)
NCBI Gene

108096

			Length	Strain/Species	Flank
genomic	108096	NCBI Gene Model \| MGI Sequence Detail	88755	C57BL/6J	± kb
transcript	NM_001267707	RefSeq \| MGI Sequence Detail	2624	C57BL/6
polypeptide	Q91YY5	UniProt \| EBI \| MGI Sequence Detail	670	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015967 solute carrier organic anion transporter family member 1A5

(term hierarchy)
InterPro Domains

IPR002350 Kazal domain

IPR036058 Kazal domain superfamily

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR004156 Organic anion transporter polypeptide
GlyGen

Q91YY5 4 sites

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All nucleic 23

cDNA 20

Primer pair 3

Microarray probesets 3

Summaries

All 41

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 13
Earliest

J:66643 Walters HC, et al., Expression, transport properties, and chromosomal location of organic anion transporter subtype 3. Am J Physiol Gastrointest Liver Physiol. 2000 Dec;279(6):G1188-200
Latest

J:334921 Truong JK, et al., Active enterohepatic cycling is not required for the choleretic actions of 24-norUrsodeoxycholic acid in mice. JCI Insight. 2023 Mar 22;8(6)

TSS for Slco1a5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr63946	Chr6:142268768-142268788 (-)	-71 bp
Tssr63945	Chr6:142268752-142268766 (-)	-52 bp
Tssr63944	Chr6:142268736-142268748 (-)	-35 bp
Tssr63943	Chr6:142268704-142268733 (-)	-12 bp
Tssr63942	Chr6:142268693-142268703 (-)	9 bp
Tssr63941	Chr6:142268667-142268683 (-)	32 bp
Tssr63940	Chr6:142224572-142224581 (-)	44,130 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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