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Slco3a1 Gene Detail
Summary
  • Symbol
    Slco3a1
  • Name
    solute carrier organic anion transporter family, member 3a1
  • Synonyms
    5830414C08Rik, Anr1, MJAM, OATP-D, Slc21a11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351867
    NCBI Gene: 108116
  • Alliance
    gene page
  • Transcription Start Sites
    30 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:73925167-74204528 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 42.95 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9068 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351867
 protein coding gene Chr7:73925166-74204528 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032372
 protein coding gene Chr7:75880966-76200316 (-)
A/J MGP_AJ_G0032351
 protein coding gene Chr7:74157223-74444780 (-)
AKR/J MGP_AKRJ_G0032287
 protein coding gene Chr7:75734440-76035597 (-)
BALB/cJ MGP_BALBcJ_G0032363
 protein coding gene Chr7:73913294-74199830 (-)
C3H/HeJ MGP_C3HHeJ_G0032076
 protein coding gene Chr7:76490071-76782783 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032855
 protein coding gene Chr7:79000725-79313742 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029863
 protein coding gene Chr7:76774886-77058655 (-)
CAST/EiJ MGP_CASTEiJ_G0031404
 protein coding gene Chr7:67345373-67645005 (-)
CBA/J MGP_CBAJ_G0032042
 protein coding gene Chr7:81561031-81873959 (-)
DBA/2J MGP_DBA2J_G0032197
 protein coding gene Chr7:72818498-73107245 (-)
FVB/NJ MGP_FVBNJ_G0032152
 protein coding gene Chr7:72857391-73136968 (-)
LP/J MGP_LPJ_G0032278
 protein coding gene Chr7:77113636-77413802 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032189
 protein coding gene Chr7:81701391-82002989 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032873
 protein coding gene Chr7:75197098-75487578 (-)
PWK/PhJ MGP_PWKPhJ_G0031124
 protein coding gene Chr7:65944799-66289943 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030965
 protein coding gene Chr7:62279906-62585196 (-)
WSB/EiJ MGP_WSBEiJ_G0031522
 protein coding gene Chr7:75552589-75850693 (-)



Homology
more
  • Human Ortholog
    SLCO3A1, solute carrier organic anion transporter family member 3A1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLCO3A1, solute carrier organic anion transporter family member 3A1
  • Synonyms
    OATP3A1, OATP-D, OATPD, OATP-RP3, OATPRP3, SLC21A11
  • Links
    NCBI Gene ID: 28232
    neXtProt AC: NX_Q9UIG8
    UniProt: Q9UIG8

  • Chr Location
    15q26.1; chr15:91853708-92172435 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice for a null endonuclease-mediated mutation exhibit shorter survival times, increased hepatic levels of bile acid, and develop more liver injury after induction of cholestasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    15
  • cDNA Data
    88
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025790 Ensembl Gene Model | MGI Sequence Detail 279362 C57BL/6J ±  kb
    transcript ENSMUST00000026897 Ensembl | MGI Sequence Detail 4589 Not Applicable  
    polypeptide ENSMUSP00000026897 Ensembl | MGI Sequence Detail 710 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      cDNA 88
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1328325, MGI:1926070, MGI:2142386
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 15
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:284228 Ikegami K, et al., Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice. Sci Rep. 2019 Sep 20;9(1):13634
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory