About   Help   FAQ
Slco1a1 Gene Detail
Summary
  • Symbol
    Slco1a1
  • Name
    solute carrier organic anion transporter family, member 1a1
  • Synonyms
    Oatp1, Oatp1a1, Slc21a1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351891
    NCBI Gene: 28248
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:141853008-141892688 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 73.09 cM, cytoband A3-A5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1213 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351891
 protein coding gene Chr6:141853007-141892688 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031456
 protein coding gene Chr6:146694136-146736548 (-)
A/J MGP_AJ_G0031431
 protein coding gene Chr6:140911218-140952445 (-)
AKR/J MGP_AKRJ_G0031359
 protein coding gene Chr6:145108129-145152393 (-)
BALB/cJ MGP_BALBcJ_G0031438
 protein coding gene Chr6:140703880-140744861 (-)
C3H/HeJ MGP_C3HHeJ_G0031160
 protein coding gene Chr6:145164246-145206341 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031900
 protein coding gene Chr6:150693282-150734438 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030528
 protein coding gene Chr6:144723247-144773701 (-)
CBA/J MGP_CBAJ_G0031120
 protein coding gene Chr6:156428979-156470824 (-)
DBA/2J MGP_DBA2J_G0031277
 protein coding gene Chr6:139718445-139757873 (-)
FVB/NJ MGP_FVBNJ_G0031228
 protein coding gene Chr6:138509627-138547415 (-)
LP/J MGP_LPJ_G0031361
 protein coding gene Chr6:146833320-146878238 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031268
 protein coding gene Chr6:160337325-160389023 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031932
 protein coding gene Chr6:144936557-144980067 (-)
PWK/PhJ MGP_PWKPhJ_G0030255
 protein coding gene Chr6:138231430-138273148 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030079
 protein coding gene Chr6:143149725-143190989 (-)
WSB/EiJ MGP_WSBEiJ_G0030621
 protein coding gene Chr6:145587476-145630528 (-)



Homology
more
  • Human Ortholog
    SLCO1A2, solute carrier organic anion transporter family member 1A2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLCO1A2, solute carrier organic anion transporter family member 1A2
  • Synonyms
    OATP, OATP1A2, OATP-A, SLC21A3
  • Links
    NCBI Gene ID: 6579
    neXtProt AC: NX_P46721
    UniProt: P46721

  • Chr Location
    12p12.1; chr12:21264600-21419634 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired organic anion transporter activity and urinary metabolomic profiles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    61
  • cDNA Data
    30
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041698 Ensembl Gene Model | MGI Sequence Detail 39681 C57BL/6J ±  kb
    transcript ENSMUST00000042119 Ensembl | MGI Sequence Detail 3395 Not Applicable  
    polypeptide ENSMUSP00000037022 Ensembl | MGI Sequence Detail 670 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 31
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1351890
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:59386 Hagenbuch B, et al., Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X. Biochem J. 2000 Jan 1;345 Pt 1:115-20
    • Latest
      J:334921 Truong JK, et al., Active enterohepatic cycling is not required for the choleretic actions of 24-norUrsodeoxycholic acid in mice. JCI Insight. 2023 Mar 22;8(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory