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Nr2f1 Gene Detail
Summary
  • Symbol
    Nr2f1
  • Name
    nuclear receptor subfamily 2, group F, member 1
  • Synonyms
    COUP-TF1, COUP-TFI, Erbal3, Tcfcoup1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352451
    NCBI Gene: 13865
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:78337090-78346954 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 41.38 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    169 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352451
 protein coding gene Chr13:78337090-78347876 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020784
 protein coding gene Chr13:78760126-78770910 (-)
A/J MGP_AJ_G0020740
 protein coding gene Chr13:76065646-76076507 (-)
AKR/J MGP_AKRJ_G0020713
 protein coding gene Chr13:78375487-78386268 (-)
BALB/cJ MGP_BALBcJ_G0020736
 protein coding gene Chr13:76588428-76597212 (-)
C3H/HeJ MGP_C3HHeJ_G0020530
 protein coding gene Chr13:78044194-78056630 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021173
 protein coding gene Chr13:81402843-81414435 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018741
 protein coding gene Chr13:72721033-72731752 (-)
CAST/EiJ MGP_CASTEiJ_G0020048
 protein coding gene Chr13:77130609-77163470 (-)
CBA/J MGP_CBAJ_G0020489
 protein coding gene Chr13:84464992-84474646 (-)
DBA/2J MGP_DBA2J_G0020614
 protein coding gene Chr13:75763845-75774671 (-)
FVB/NJ MGP_FVBNJ_G0020594
 protein coding gene Chr13:74857458-74867856 (-)
LP/J MGP_LPJ_G0020687
 protein coding gene Chr13:79027447-79038550 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020623
 protein coding gene Chr13:82948000-82961405 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021213
 protein coding gene Chr13:77712795-77724602 (-)
PWK/PhJ MGP_PWKPhJ_G0019801
 protein coding gene Chr13:74649702-74670937 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019624
 protein coding gene Chr13:73972902-74005159 (-)
WSB/EiJ MGP_WSBEiJ_G0020105
 protein coding gene Chr13:78166391-78177876 (-)



Homology
more
  • Human Ortholog
    NR2F1, nuclear receptor subfamily 2 group F member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR2F1, nuclear receptor subfamily 2 group F member 1
  • Synonyms
    BBOAS, BBSOAS, COUPTF1, COUP-TFI, EAR-3, EAR3, ERBAL3, SVP44, TCFCOUP1, TFCOUP1
  • Links
    NCBI Gene ID: 7025
    neXtProt AC: NX_P10589
    UniProt: P10589

  • Chr Location
    5q15; chr5:93583222-93594611 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nr2f1 mouse models; 1 with human NR2F1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 5 alleles in 5 genetic backgrounds
    16 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele die perinatally with axon guidance defects in all forebrain commissures. Homozygotes for another null allele show neonatal death, impaired cranial ganglion IX formation and axon guidance, increased cochlear HC and support cell number, and altered cortex regionalization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1188
  • Tissues
    295
  • cDNA Data
    43
  • Literature Summary
    130
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13865 NCBI Gene Model | MGI Sequence Detail 9865 C57BL/6J ±  kb
    transcript NM_001403775 RefSeq | MGI Sequence Detail 2371 ZRU/MplStud  
    polypeptide Q60632 UniProt | EBI | MGI Sequence Detail 422 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000011404 COUP transcription factor 1
      (term hierarchy)
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR050274 Nuclear hormone receptor family NR2 subfamily
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    • GlyGen
      Q60632 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 85
      Genomic 14
      cDNA 49
      Primer pair 12
      Other 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18611, MGD-MRK-33774, MGI:101801
    References
    more
    • Summaries
      All 188
      Developmental Gene Expression 130
      Diseases 1
      Gene Ontology 8
      Phenotypes 47
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:354182 Sun M, et al., ERK signaling expands mammalian cortical radial glial cells and extends the neurogenic period. Proc Natl Acad Sci U S A. 2024 Mar 26;121(13):e2314802121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory