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Nr2f6 Gene Detail
Summary
  • Symbol
    Nr2f6
  • Name
    nuclear receptor subfamily 2, group F, member 6
  • Synonyms
    COUP-TF3, EAR2, Erbal2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352453
    NCBI Gene: 13864
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71826762-71834593 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    159 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352453
 protein coding gene Chr8:71826762-71834604 (-)
129S1/SvImJ ENSMUSG00200030104
 protein coding gene Chr8:66421942-66431325 (-)
A/J ENSMUSG00195015136
 protein coding gene Chr8:66870571-66879959 (-)
AKR/J ENSMUSG00220021767
 protein coding gene Chr8:66908407-66917802 (-)
BALB/cJ ENSMUSG00180028000
 protein coding gene Chr8:66604697-66614080 (-)
C3H/HeJ ENSMUSG00175020202
 protein coding gene Chr8:66807146-66816529 (-)
C57BL/6NJ ENSMUSG00215026072
 protein coding gene Chr8:66382906-66392294 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031180
 protein coding gene Chr8:63481601-63489434 (-)
CAST/EiJ ENSTCUG00005036465
 protein coding gene Chr8:66407693-66417090 (-)
CBA/J ENSMUSG00210033258
 protein coding gene Chr8:66650752-66660135 (-)
DBA/2J ENSMUSG00185011544
 protein coding gene Chr8:72810389-72819772 (-)
FVB/NJ ENSMUSG00205040343
 protein coding gene Chr8:65902720-65912103 (-)
JF1/MsJ ENSUMUG00000011728
 protein coding gene Chr8:75074115-75083511 (-)
LP/J ENSMUSG00230028347
 protein coding gene Chr8:76421877-76431260 (-)
NOD/ShiLtJ ENSMUSG00190022782
 protein coding gene Chr8:66566108-66575496 (-)
NZO/HlLtJ ENSMUSG00225047224
 protein coding gene Chr8:79822008-79831391 (-)
PWK/PhJ ENSLUMG00010027346
 protein coding gene Chr8:66538370-66547759 (-)
SPRET/EiJ ENSMSPG00010039024
 protein coding gene Chr8:68230068-68239617 (-)
WSB/EiJ ENSIUOG00005021985
 protein coding gene Chr8:67419463-67428857 (-)



Homology
more
  • Human Ortholog
    NR2F6, nuclear receptor subfamily 2 group F member 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR2F6, nuclear receptor subfamily 2 group F member 6
  • Synonyms
    EAR-2, EAR2, ERBAL2
  • Links
    NCBI Gene ID: 2063
    UniProt: P10588

  • Chr Location
    19p13.11; chr19:17231883-17245919 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial agenesis of the locus coeruleus, increased thermal nociception, and defective circadian behavior including a delayed entrainment to shifted light-dark cycles and reduced anticipatory locomotor activity in restricted feeding experiments.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    912
  • Tissues
    219
  • cDNA Data
    18
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13864 NCBI Gene Model | MGI Sequence Detail 7832 C57BL/6J ±  kb
    transcript NM_001417423 RefSeq | MGI Sequence Detail 2346 ZRU/MplStud  
    polypeptide P43136 UniProt | EBI | MGI Sequence Detail 390 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000029648 nuclear receptor subfamily 2 group F member 6
      (term hierarchy)
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR050274 Nuclear hormone receptor family NR2 subfamily
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    • GlyGen
      P43136 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 19
      Primer pair 5
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16308, MGI:2142737, MGI:99530
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 20
      Gene Ontology 11
      Phenotypes 22
    • Earliest
      J:18334 Barnhart KM, et al., The sequence of a murine cDNA encoding Ear-2, a nuclear orphan receptor. Gene. 1994 May 16;142(2):313-4
    • Latest
      J:383426 Humer D, et al., NR2F6 deletion revives CAR-T cell function and induces antigen-agnostic immune memory in solid tumors. Nat Commun. 2026 Feb 27;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory