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Nr4a2 Gene Detail
Summary
  • Symbol
    Nr4a2
  • Name
    nuclear receptor subfamily 4, group A, member 2
  • Synonyms
    HZF-3, Nurr1, RNR-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352456
    NCBI Gene: 18227
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:56996842-57014015 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 31.66 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    274 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352456
 protein coding gene Chr2:56996842-57014152 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025743
 protein coding gene Chr2:56593124-56610187 (-)
A/J MGP_AJ_G0025719
 protein coding gene Chr2:54443304-54461700 (-)
AKR/J MGP_AKRJ_G0025689
 protein coding gene Chr2:55937091-55956782 (-)
BALB/cJ MGP_BALBcJ_G0025714
 protein coding gene Chr2:54543807-54562216 (-)
C3H/HeJ MGP_C3HHeJ_G0025475
 protein coding gene Chr2:55997241-56015224 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026160
 protein coding gene Chr2:58349927-58368669 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023566
 protein coding gene Chr2:52071437-52088614 (-)
CAST/EiJ MGP_CASTEiJ_G0024940
 protein coding gene Chr2:56019818-56037270 (-)
CBA/J MGP_CBAJ_G0025455
 protein coding gene Chr2:60468448-60490595 (-)
DBA/2J MGP_DBA2J_G0025586
 protein coding gene Chr2:54057196-54074408 (-)
FVB/NJ MGP_FVBNJ_G0025548
 protein coding gene Chr2:53611287-53628564 (-)
LP/J MGP_LPJ_G0025674
 protein coding gene Chr2:56473902-56494231 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025579
 protein coding gene Chr2:62174860-62192866 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026218
 protein coding gene Chr2:55919605-55936794 (-)
PWK/PhJ MGP_PWKPhJ_G0024681
 protein coding gene Chr2:53866240-53883970 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024487
 protein coding gene Chr2:56039914-56057095 (-)
WSB/EiJ MGP_WSBEiJ_G0025007
 protein coding gene Chr2:56223412-56243803 (-)



Homology
more
  • Human Ortholog
    NR4A2, nuclear receptor subfamily 4 group A member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR4A2, nuclear receptor subfamily 4 group A member 2
  • Synonyms
    HZF-3, IDLDP, NOT, NURR1, RNR1, TINUR
  • Links
    NCBI Gene ID: 4929
    neXtProt AC: NX_P43354
    UniProt: P43354

  • Chr Location
    2q24.1; chr2:156324437-156342348 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Nr4a2 mouse models; 1 with human NR4A2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 4 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    3 images
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene fail to develop dopaminergic neurons in the mesencephalon and die within the first 12 hours of life. Heterozygotes suffer from reduced motor performance in old age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    92
  • GO References
    40
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1103
  • Tissues
    247
  • cDNA Data
    15
  • Literature Summary
    197
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026826 Ensembl Gene Model | MGI Sequence Detail 17174 C57BL/6J ±  kb
    transcript ENSMUST00000028166 Ensembl | MGI Sequence Detail 3568 Not Applicable  
    polypeptide ENSMUSP00000028166 Ensembl | MGI Sequence Detail 598 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000011409 nuclear receptor subfamily 4 group A member 2
      (term hierarchy)
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR003070 Nuclear receptor subfamily 4 group A member 1-3
      IPR003073 Nuclear receptor subfamily 4 group A member 2
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 8
      cDNA 16
      Primer pair 9
      Other 10

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-37459, MGI:108416
    References
    more
    • Summaries
      All 327
      Developmental Gene Expression 197
      Diseases 2
      Gene Ontology 40
      Phenotypes 72
    • Earliest
      J:33283 Law SW, et al., Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol. 1992 Dec;6(12):2129-35
    • Latest
      J:355331 Mao Y, et al., Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance. J Neuroinflammation. 2024 Oct 4;21(1):249
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory