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Nr2c1 Gene Detail
Summary
  • Symbol
    Nr2c1
  • Name
    nuclear receptor subfamily 2, group C, member 1
  • Synonyms
    4831444H07Rik, Eenr, TR2, Tr2-11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352465
    NCBI Gene: 22025
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:93983885-94033073 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 48.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1463 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352465
 protein coding gene Chr10:93983491-94033078 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017661
 protein coding gene Chr10:95612167-95667412 (+)
A/J MGP_AJ_G0017640
 protein coding gene Chr10:92261129-92310514 (+)
AKR/J MGP_AKRJ_G0017598
 protein coding gene Chr10:94903081-94952991 (+)
BALB/cJ MGP_BALBcJ_G0017603
 protein coding gene Chr10:92535506-92589303 (+)
C3H/HeJ MGP_C3HHeJ_G0017426
 protein coding gene Chr10:94897843-94948432 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018060
 protein coding gene Chr10:98766921-98820466 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015741
 protein coding gene Chr10:87844640-87895224 (+)
CAST/EiJ MGP_CASTEiJ_G0016991
 protein coding gene Chr10:94902521-94953364 (+)
CBA/J MGP_CBAJ_G0017395
 protein coding gene Chr10:102851283-102911337 (+)
DBA/2J MGP_DBA2J_G0017501
 protein coding gene Chr10:91355778-91405163 (+)
FVB/NJ MGP_FVBNJ_G0017493
 protein coding gene Chr10:90595893-90645455 (+)
LP/J MGP_LPJ_G0017575
 protein coding gene Chr10:96220503-96270674 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017524
 protein coding gene Chr10:104113218-104165696 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018097
 protein coding gene Chr10:94806058-94859522 (+)
PWK/PhJ MGP_PWKPhJ_G0016772
 protein coding gene Chr10:91451711-91501578 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016560
 protein coding gene Chr10:93604832-93665760 (+)
WSB/EiJ MGP_WSBEiJ_G0017050
 protein coding gene Chr10:94771708-94822545 (+)



Homology
more
  • Human Ortholog
    NR2C1, nuclear receptor subfamily 2 group C member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR2C1, nuclear receptor subfamily 2 group C member 1
  • Synonyms
    TR2
  • Links
    NCBI Gene ID: 7181
    neXtProt AC: NX_P13056
    UniProt: P13056

  • Chr Location
    12q22; chr12:95020229-95073628 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable, fertile and do not exhibit any defects in testis development or in spermatogenesis; no gross defects were detected in the central nervous system and normal motor neuron cell numbers were noted.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1008
  • Tissues
    221
  • cDNA Data
    20
  • Literature Summary
    18
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005897 Ensembl Gene Model | MGI Sequence Detail 49189 C57BL/6J ±  kb
transcript ENSMUST00000092213 Ensembl | MGI Sequence Detail 2376 Not Applicable  
polypeptide ENSMUSP00000089858 Ensembl | MGI Sequence Detail 590 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011399 nuclear receptor subfamily 2 group C member 1
    (term hierarchy)
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR050274 Nuclear hormone receptor family NR2 subfamily
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR035500 Nuclear hormone receptor-like domain superfamily
    IPR048245 Nuclear receptor subfamily 2 group C member 1/2-like, DNA-binding domain
    IPR048246 Nuclear receptor subfamily 2 group C member 1/2-like, ligand binding domain
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
less
  • All nucleic 34
    Genomic 7
    cDNA 20
    Primer pair 5
    Other 2

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-26050, MGD-MRK-26100, MGI:104613, MGI:104660, MGI:2443924
References
more
  • Summaries
    All 76
    Developmental Gene Expression 18
    Gene Ontology 12
    Phenotypes 21
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:248772 Olivares AM, et al., The nuclear hormone receptor gene Nr2c1 (Tr2) is a critical regulator of early retina cell patterning. Dev Biol. 2017 Sep 1;429(1):343-355
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory