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Mga Gene Detail
Summary
  • Symbol
    Mga
  • Name
    MAX gene associated
  • Synonyms
    C130042M01Rik, D030062C11Rik, Mad5, Mga
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352483
    NCBI Gene: 29808
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:119727709-119800062 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.97 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1075 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352483
 protein coding gene Chr2:119702974-119800610 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026354
 protein coding gene Chr2:122745289-122822533 (+)
A/J MGP_AJ_G0026315
 protein coding gene Chr2:117710304-117787961 (+)
AKR/J MGP_AKRJ_G0026294
 protein coding gene Chr2:120998447-121072587 (+)
BALB/cJ MGP_BALBcJ_G0026328
 protein coding gene Chr2:117952178-118026579 (+)
C3H/HeJ MGP_C3HHeJ_G0026074
 protein coding gene Chr2:121467183-121535055 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026775
 protein coding gene Chr2:126751090-126828409 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024155
 protein coding gene Chr2:112734566-112807669 (+)
CAST/EiJ MGP_CASTEiJ_G0025536
 protein coding gene Chr2:121779849-121858010 (+)
CBA/J MGP_CBAJ_G0026050
 protein coding gene Chr2:131177628-131266074 (+)
DBA/2J MGP_DBA2J_G0026189
 protein coding gene Chr2:117102897-117175080 (+)
FVB/NJ MGP_FVBNJ_G0026151
 protein coding gene Chr2:115938059-116011399 (+)
LP/J MGP_LPJ_G0026290
 protein coding gene Chr2:123006678-123081794 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026170
 protein coding gene Chr2:135494096-135582594 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026830
 protein coding gene Chr2:121118535-121197768 (+)
PWK/PhJ MGP_PWKPhJ_G0025272
 protein coding gene Chr2:116698023-116772947 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025071
 protein coding gene Chr2:120317007-120390708 (+)
WSB/EiJ MGP_WSBEiJ_G0025605
 protein coding gene Chr2:121960086-122036019 (+)



Homology
more
  • Human Ortholog
    MGA, MAX dimerization protein MGA
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MGA, MAX dimerization protein MGA
  • Synonyms
    MAD5, MXD5
  • Links
    NCBI Gene ID: 23269
    neXtProt AC: NX_Q8IWI9
    UniProt: Q8IWI9

  • Chr Location
    15q15.1; chr15:41621134-41773081 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a gene trap allele die shortly after implantation due to defective development of the inner cell mass (ICM) and the epiblast. ICM derivatives fail to develop past E4.5 and show increased apoptosis but no change in cell proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    971
  • Tissues
    188
  • cDNA Data
    31
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033943 Ensembl Gene Model | MGI Sequence Detail 72354 C57BL/6J ±  kb
    transcript ENSMUST00000110774 Ensembl | MGI Sequence Detail 13931 Not Applicable  
    polypeptide ENSMUSP00000106401 Ensembl | MGI Sequence Detail 3042 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010376 MAX gene-associated protein
      (term hierarchy)
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR037935 MAX gene-associated protein, basic Helix-Loop-Helix-zipper domain
      IPR032060 MGA, conserved domain
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR008967 p53-like transcription factor, DNA-binding domain superfamily
      IPR036960 T-box superfamily
      IPR001699 T-box transcription factor
      IPR046360 T-box transcription factor, DNA-binding domain
      IPR018186 Transcription factor, T-box, conserved site
    • GlyGen
      A2AWL7 9 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (7 sites)
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 32
      Primer pair 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2139266, MGI:2139508, MGI:2441880, MGI:2441937
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 12
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory