Zfp385a MGI Mouse Gene Detail - MGI:1352495

Symbol

Zfp385a
Name

zinc finger protein 385A
Synonyms

Hzf, Zfp385

Feature Type

protein coding gene
IDs

MGI:1352495
NCBI Gene: 29813
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr15:103222322-103248520 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 58.88 cM, cytoband F3
Mapping Data

1 experiment

SNPs within 2kb

437 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352495	protein coding gene	Chr15:103222322-103248537 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022439	protein coding gene	Chr15:105583845-105609770 (-)
A/J	MGP_AJ_G0022401	protein coding gene	Chr15:101397843-101425010 (-)
AKR/J	MGP_AKRJ_G0022376	protein coding gene	Chr15:104478394-104506260 (-)
BALB/cJ	MGP_BALBcJ_G0022405	protein coding gene	Chr15:101442671-101468576 (-)
C3H/HeJ	MGP_C3HHeJ_G0022172	protein coding gene	Chr15:104570234-104597910 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022854	protein coding gene	Chr15:109464676-109492343 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020377	protein coding gene	Chr15:97160116-97186085 (-)
CAST/EiJ	MGP_CASTEiJ_G0021698	protein coding gene	Chr15:105441648-105469888 (-)
CBA/J	MGP_CBAJ_G0022141	protein coding gene	Chr15:113322421-113353612 (-)
DBA/2J	MGP_DBA2J_G0022272	protein coding gene	Chr15:100673660-100699527 (-)
FVB/NJ	MGP_FVBNJ_G0022248	protein coding gene	Chr15:99733360-99759027 (-)
LP/J	MGP_LPJ_G0022341	protein coding gene	Chr15:105714477-105741010 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022270	protein coding gene	Chr15:116815028-116842079 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022866	protein coding gene	Chr15:104513331-104539033 (-)
PWK/PhJ	MGP_PWKPhJ_G0021438	protein coding gene	Chr15:100853841-100879820 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021270	protein coding gene	Chr15:104350850-104377396 (-)
WSB/EiJ	MGP_WSBEiJ_G0021748	protein coding gene	Chr15:105135633-105164662 (-)

Human Ortholog

ZNF385A, zinc finger protein 385A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF385A, zinc finger protein 385A
Synonyms

HZF, RZF, ZFP385, ZNF385
Links

HGNC:17521

NCBI Gene ID: 25946

neXtProt AC: NX_Q96PM9

UniProt: Q96PM9
Chr Location

12q13.13; chr12:54369133-54391298 (-) GRCh38

MGI Vertebrate Homology

Zfp385a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZNF385A
Gene Tree

Zfp385a

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Phenotype Summary

9 phenotypes from 2 alleles in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Gene trapped

14
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display partial postnatal lethality with gastrointestinal and intracranial hemorrhages, abnormal megakaryocyte development, and reduced body size.

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All GO Annotations

35
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

930
Tissues

126
cDNA Data

54
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

56
RefSeq

22
UniProt

2
CCDS

CCDS49743.1, CCDS88860.1

Ensembl

ENSMUSG00000000552 (Evidence)
NCBI Gene

29813

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000552	Ensembl Gene Model \| MGI Sequence Detail	26199	C57BL/6J	± kb
transcript	ENSMUST00000168828	Ensembl \| MGI Sequence Detail	2298	Not Applicable
polypeptide	ENSMUSP00000130176	Ensembl \| MGI Sequence Detail	386	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017859 zinc finger protein 385A

(term hierarchy)
InterPro Domains

IPR003604 Matrin/U1-C-like, C2H2-type zinc finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

IPR051845 Zinc finger protein 385

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All nucleic 60

cDNA 55

Primer pair 4

Other 1

Microarray probesets 3

Summaries

All 45

Developmental Gene Expression 12

Gene Ontology 12

Phenotypes 11
Earliest

J:58923 Hidaka M, et al., Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells. Mech Dev. 2000 Jan;90(1):3-15
Latest

J:222424 Tsuboi D, et al., Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity. Nat Neurosci. 2015 May;18(5):698-707

TSS for Zfp385a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136771	Chr15:103248557-103248568 (-)	-43 bp
Tssr136770	Chr15:103248529-103248552 (-)	-21 bp
Tssr136769	Chr15:103248512-103248527 (-)	0 bp
Tssr136768	Chr15:103242698-103242774 (-)	5,784 bp
Tssr136767	Chr15:103242237-103242263 (-)	6,270 bp
Tssr136766	Chr15:103241782-103241817 (-)	6,720 bp
Tssr136765	Chr15:103231922-103231993 (-)	16,562 bp
Tssr136764	Chr15:103231856-103231873 (-)	16,655 bp
Tssr136763	Chr15:103231644-103231694 (-)	16,851 bp
Tssr136762	Chr15:103228150-103228153 (-)	20,368 bp
Tssr136761	Chr15:103228033-103228039 (-)	20,484 bp
Tssr136760	Chr15:103226689-103226701 (-)	21,825 bp
Tssr136759	Chr15:103224962-103224967 (-)	23,555 bp
Tssr136758	Chr15:103224424-103224444 (-)	24,086 bp
Tssr136757	Chr15:103223499-103223511 (-)	25,015 bp
Tssr136756	Chr15:103223423-103223450 (-)	25,083 bp
Tssr136755	Chr15:103223384-103223410 (-)	25,123 bp
Tssr136754	Chr15:103223303-103223326 (-)	25,205 bp
Tssr136753	Chr15:103223168-103223181 (-)	25,345 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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