Stau2 MGI Mouse Gene Detail - MGI:1352508 - staufen double-stranded RNA binding protein 2

Symbol

Stau2
Name

staufen double-stranded RNA binding protein 2

Feature Type

protein coding gene
IDs

MGI:1352508
NCBI Gene: 29819
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:16298898-16590336 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 5.05 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

7592 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352508	protein coding gene	Chr1:16298898-16591228 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0015855	protein coding gene	Chr1:13709096-14024395 (-)
A/J	MGP_AJ_G0015836	protein coding gene	Chr1:13547946-13850363 (-)
AKR/J	MGP_AKRJ_G0015795	protein coding gene	Chr1:13583318-13864226 (-)
BALB/cJ	MGP_BALBcJ_G0015792	protein coding gene	Chr1:13274192-13584322 (-)
C3H/HeJ	MGP_C3HHeJ_G0015626	protein coding gene	Chr1:13579964-13899799 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016246	protein coding gene	Chr1:14319461-14637603 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013967	protein coding gene	Chr1:12168514-12461003 (-)
CAST/EiJ	MGP_CASTEiJ_G0015207	protein coding gene	Chr1:13672933-13971833 (-)
CBA/J	MGP_CBAJ_G0015599	protein coding gene	Chr1:14656750-14979719 (-)
DBA/2J	MGP_DBA2J_G0015698	protein coding gene	Chr1:13146369-13458336 (-)
FVB/NJ	MGP_FVBNJ_G0015703	protein coding gene	Chr1:12964383-13248512 (-)
LP/J	MGP_LPJ_G0015770	protein coding gene	Chr1:13913270-14229172 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015722	protein coding gene	Chr1:15293238-15602688 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016293	protein coding gene	Chr1:13540595-13831545 (-)
PWK/PhJ	MGP_PWKPhJ_G0014991	protein coding gene	Chr1:12948372-13229720 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014772	protein coding gene	Chr1:13713353-14024364 (-)
WSB/EiJ	MGP_WSBEiJ_G0015270	protein coding gene	Chr1:13473466-13767007 (-)

Human Ortholog

STAU2, staufen double-stranded RNA binding protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STAU2, staufen double-stranded RNA binding protein 2
Synonyms

39K2, 39K3
Links

HGNC:11371

NCBI Gene ID: 27067

neXtProt AC: NX_Q9NUL3

UniProt: Q9NUL3
Chr Location

8q21.11; chr8:73420369-73747708 (-) GRCh38

MGI Vertebrate Homology

Stau2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STAU2
Gene Tree

Stau2

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Phenotype Summary

14 phenotypes from 3 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a hypomorphic gene trap allele show impaired motor coordination but increased motor learning capacity in the rotarod test.

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All GO Annotations

53
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

971
Tissues

89
cDNA Data

58
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stau2

ZFIN stau2

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All Sequences

105
RefSeq

30
UniProt

7
CCDS

CCDS14831.2, CCDS48223.1, CCDS83528.1, CCDS83529.1

Ensembl

ENSMUSG00000025920 (Evidence)
NCBI Gene

29819

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025920	Ensembl Gene Model \| MGI Sequence Detail	291439	C57BL/6J	± kb
transcript	ENSMUST00000162751	Ensembl \| MGI Sequence Detail	3030	Not Applicable
polypeptide	ENSMUSP00000124505	Ensembl \| MGI Sequence Detail	570	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000015727 double-stranded RNA-binding protein Staufen homolog 2

(term hierarchy)
PDB

1UHZ
InterPro Domains

IPR014720 Double-stranded RNA-binding domain

IPR051740 Double-stranded RNA-binding domain-containing protein

IPR044474 Staufen 2, fourth double-stranded RNA binding domain

IPR044464 Staufen 2, second double-stranded RNA binding domain

IPR044473 Staufen 2, third double-stranded RNA binding domain

IPR032478 Staufen, C-terminal
GlyGen

Q8CJ67 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)

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All nucleic 64

cDNA 60

Primer pair 4

Microarray probesets 7

Summaries

All 55

Developmental Gene Expression 13

Gene Ontology 7

Phenotypes 12
Earliest

J:58925 Buchner G, et al., Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region. Genomics. 1999 Nov 15;62(1):113-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Stau2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11042	Chr1:16590330-16590357 (-)	-8 bp
Tssr11041	Chr1:16590291-16590319 (-)	31 bp
Tssr11040	Chr1:16590247-16590263 (-)	81 bp
Tssr11039	Chr1:16589508-16589560 (-)	802 bp
Tssr11038	Chr1:16589425-16589484 (-)	881 bp
Tssr11037	Chr1:16415697-16415711 (-)	174,632 bp
Tssr11036	Chr1:16365116-16365121 (-)	225,217 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24