Cspg5 MGI Mouse Gene Detail - MGI:1352747 - chondroitin sulfate proteoglycan 5

Symbol

Cspg5
Name

chondroitin sulfate proteoglycan 5
Synonyms

CALEB, neuroglycan C, NGC

Feature Type

protein coding gene
IDs

MGI:1352747
NCBI Gene: 29873
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr9:110072851-110091644 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 59.89 cM
Mapping Data

2 experiments

SNPs within 2kb

504 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352747	protein coding gene	Chr9:110072851-110091644 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035343	protein coding gene	Chr9:112382168-112398194 (+)
A/J	MGP_AJ_G0035324	protein coding gene	Chr9:108299674-108317505 (+)
AKR/J	MGP_AKRJ_G0035255	protein coding gene	Chr9:110988757-111004764 (+)
BALB/cJ	MGP_BALBcJ_G0035319	protein coding gene	Chr9:108043283-108059264 (+)
C3H/HeJ	MGP_C3HHeJ_G0035027	protein coding gene	Chr9:111484331-111502225 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035841	protein coding gene	Chr9:115430530-115446613 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032727	protein coding gene	Chr9:105526369-105542410 (+)
CAST/EiJ	MGP_CASTEiJ_G0034333	protein coding gene	Chr9:111275252-111292085 (+)
CBA/J	MGP_CBAJ_G0034994	protein coding gene	Chr9:119730254-119746025 (+)
DBA/2J	MGP_DBA2J_G0035153	protein coding gene	Chr9:107762343-107779881 (+)
FVB/NJ	MGP_FVBNJ_G0035100	protein coding gene	Chr9:106587577-106603378 (+)
LP/J	MGP_LPJ_G0035232	protein coding gene	Chr9:112681038-112697903 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035140	protein coding gene	Chr9:121091244-121108265 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035861	protein coding gene	Chr9:111307763-111326250 (+)
PWK/PhJ	MGP_PWKPhJ_G0034040	protein coding gene	Chr9:108000854-108016825 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033875	protein coding gene	Chr9:111393957-111410125 (+)
WSB/EiJ	MGP_WSBEiJ_G0034454	protein coding gene	Chr9:111191848-111207598 (+)

Human Ortholog

CSPG5, chondroitin sulfate proteoglycan 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CSPG5, chondroitin sulfate proteoglycan 5
Synonyms

NGC
Links

HGNC:2467

NCBI Gene ID: 10675

neXtProt AC: NX_O95196

UniProt: O95196
Chr Location

3p21.31; chr3:47562238-47580792 (-) GRCh38

MGI Vertebrate Homology

Cspg5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CSPG5
Gene Tree

Cspg5

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

3
Gene trapped

10
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display decreased spontaneous postsynaptic currents, increased paired-pulse ratios, and reduced long term depression during early postnatal developmental stages.

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All GO Annotations

25
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

750
Tissues

31
cDNA Data

23
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN cspg5a, cspg5b

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All Sequences

43
RefSeq

4
UniProt

1
CCDS

CCDS52936.1, CCDS81085.1

Ensembl

ENSMUSG00000032482 (Evidence)
NCBI Gene

29873

			Length	Strain/Species	Flank
genomic	29873	NCBI Gene Model \| MGI Sequence Detail	18794	C57BL/6J	± kb
transcript	NM_001166273	RefSeq \| MGI Sequence Detail	3881	C57BL/6
polypeptide	Q71M36	UniProt \| EBI \| MGI Sequence Detail	566	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005954 chondroitin sulfate proteoglycan 5

(term hierarchy)
InterPro Domains

IPR042382 Chondroitin sulfate proteoglycan 5

IPR010555 CSPG5, sulphate attachment domain

IPR009505 Neural chondroitin sulphate proteoglycan cytoplasmic
GlyGen

Q71M36 16 sites, 7 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 26

cDNA 26

Microarray probesets 4

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MGI:2143104

Summaries

All 46

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 11
Earliest

J:59346 Aono S, et al., Genomic organization and expression pattern of mouse neuroglycan C in the cerebellar development. J Biol Chem. 2000 Jan 7;275(1):337-42
Latest

J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

TSS for Cspg5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87332	Chr9:110073988-110074012 (+)	1,149 bp
Tssr87333	Chr9:110074017-110074032 (+)	1,174 bp
Tssr87334	Chr9:110074177-110074258 (+)	1,367 bp
Tssr87335	Chr9:110074450-110074485 (+)	1,617 bp
Tssr87336	Chr9:110074489-110074559 (+)	1,673 bp
Tssr87337	Chr9:110074574-110074586 (+)	1,729 bp
Tssr87338	Chr9:110075283-110075304 (+)	2,443 bp
Tssr87339	Chr9:110076328-110076340 (+)	3,483 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24