About   Help   FAQ
Gipr Gene Detail
Summary
  • Symbol
    Gipr
  • Name
    gastric inhibitory polypeptide receptor
  • Synonyms
    glucose-dependent insulinotropic polypeptide receptor, LOC232937, LOC381853
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352753
    NCBI Gene: 381853
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:18889986-18900052 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    345 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352753
 protein coding gene Chr7:18889986-18904173 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031763
 protein coding gene Chr7:17119457-17129331 (-)
A/J MGP_AJ_G0031739
 protein coding gene Chr7:16797976-16807962 (-)
AKR/J MGP_AKRJ_G0031665
 protein coding gene Chr7:17255105-17265070 (-)
BALB/cJ MGP_BALBcJ_G0031744
 protein coding gene Chr7:16990173-17000699 (-)
C3H/HeJ MGP_C3HHeJ_G0031466
 protein coding gene Chr7:17520632-17530502 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032210
 protein coding gene Chr7:18005054-18014916 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029276
 protein coding gene Chr7:18443324-18453837 (-)
CAST/EiJ MGP_CASTEiJ_G0030809
 protein coding gene Chr7:13916887-13926750 (-)
CBA/J MGP_CBAJ_G0031428
 protein coding gene Chr7:18661048-18670918 (-)
DBA/2J MGP_DBA2J_G0031583
 protein coding gene Chr7:16733127-16742979 (-)
FVB/NJ MGP_FVBNJ_G0031535
 protein coding gene Chr7:16597600-16607451 (-)
LP/J MGP_LPJ_G0031666
 protein coding gene Chr7:17459115-17468985 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031571
 protein coding gene Chr7:18516123-18525993 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032238
 protein coding gene Chr7:16864929-16874781 (-)
PWK/PhJ MGP_PWKPhJ_G0030533
 protein coding gene Chr7:13822010-13831864 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030360
 protein coding gene Chr7:11559231-11571561 (-)
WSB/EiJ MGP_WSBEiJ_G0030909
 protein coding gene Chr7:17071452-17082372 (-)



Homology
more
  • Human Ortholog
    GIPR, gastric inhibitory polypeptide receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GIPR, gastric inhibitory polypeptide receptor
  • Synonyms
    PGQTL2
  • Links
    NCBI Gene ID: 2696
    neXtProt AC: NX_P48546
    UniProt: P48546

  • Chr Location
    19q13.32; chr19:45668221-45683722 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human GIPR associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    81 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in mild glucose intolerance due to impaired glucose-stimulated insulin secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    16
  • cDNA Data
    11
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030406 Ensembl Gene Model | MGI Sequence Detail 10067 C57BL/6J ±  kb
    transcript ENSMUST00000094790 Ensembl | MGI Sequence Detail 2856 Not Applicable  
    polypeptide ENSMUSP00000092384 Ensembl | MGI Sequence Detail 460 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007988 gastric inhibitory polypeptide receptor
      (term hierarchy)
    • PDB
      6O9H, 6O9I
    • InterPro Domains
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR001749 GPCR, family 2, gastric inhibitory polypeptide receptor
      IPR017981 GPCR, family 2-like, 7TM
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR050332 G-protein coupled receptor 2
    • GlyGen
      Q0P543 3 sites
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 11
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2685006, MGI:2685927
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 81
    • Earliest
      J:328571 Gelling RW, et al., Localization of the domains involved in ligand binding and activation of the glucose-dependent insulinotropic polypeptide receptor. Endocrinology. 1997 Jun;138(6):2640-3
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory