Hdgfl3 MGI Mouse Gene Detail - MGI:1352760

Symbol

Hdgfl3
Name

HDGF like 3
Synonyms

2700022B06Rik, Hdgfrp3, HRP-3

Feature Type

protein coding gene
IDs

MGI:1352760
NCBI Gene: 29877
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:81530999-81584221 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 45.71 cM, cytoband D2
Mapping Data

2 experiments

SNPs within 2kb

1116 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1352760	protein coding gene	Chr7:81530999-81587227 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032440	protein coding gene	Chr7:83974694-84030470 (-)
A/J	MGP_AJ_G0032418	protein coding gene	Chr7:81976988-82031290 (-)
AKR/J	MGP_AKRJ_G0032354	protein coding gene	Chr7:83804860-83857812 (-)
BALB/cJ	MGP_BALBcJ_G0032430	protein coding gene	Chr7:81642880-81695552 (-)
C3H/HeJ	MGP_C3HHeJ_G0032144	protein coding gene	Chr7:84411607-84465147 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032921	protein coding gene	Chr7:87248681-87302319 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029931	protein coding gene	Chr7:84443508-84494444 (-)
CAST/EiJ	MGP_CASTEiJ_G0031471	protein coding gene	Chr7:75352264-75410273 (-)
CBA/J	MGP_CBAJ_G0032109	protein coding gene	Chr7:90166675-90226279 (-)
DBA/2J	MGP_DBA2J_G0032264	protein coding gene	Chr7:80506430-80559411 (-)
FVB/NJ	MGP_FVBNJ_G0032218	protein coding gene	Chr7:80443701-80495284 (-)
LP/J	MGP_LPJ_G0032345	protein coding gene	Chr7:85198497-85254115 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032255	protein coding gene	Chr7:90220715-90276157 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032941	protein coding gene	Chr7:83215507-83269985 (-)
PWK/PhJ	MGP_PWKPhJ_G0031191	protein coding gene	Chr7:73726370-73780461 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031033	protein coding gene	Chr7:70211900-70267449 (-)
WSB/EiJ	MGP_WSBEiJ_G0031588	protein coding gene	Chr7:83578923-83633610 (-)

Human Ortholog

HDGFL3, HDGF like 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HDGFL3, HDGF like 3
Synonyms

CGI-142, HDGF-2, HDGF2, HDGFRP3, HRP-3
Links

HGNC:24937

NCBI Gene ID: 50810

neXtProt AC: NX_Q9Y3E1

UniProt: Q9Y3E1
Chr Location

15q25.2; chr15:83112738-83207875 (-) GRCh38

MGI Vertebrate Homology

Hdgfl3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HDGFL3
Gene Tree

Hdgfl3

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

2
Genomic Mutations

3 involving Hdgfl3
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

735
Tissues

25
cDNA Data

15
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hdgfl3

ZFIN hdgfl3

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All Sequences

51
RefSeq

4
UniProt

3
CCDS

CCDS40011.1

Ensembl

ENSMUSG00000025104 (Evidence)
NCBI Gene

29877

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025104	Ensembl Gene Model \| MGI Sequence Detail	53223	C57BL/6J	± kb
transcript	ENSMUST00000026094	Ensembl \| MGI Sequence Detail	2865	Not Applicable
polypeptide	ENSMUSP00000026094	Ensembl \| MGI Sequence Detail	205	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008493 hepatoma-derived growth factor-related protein 3

(term hierarchy)
PDB

1N27
InterPro Domains

IPR000313 PWWP domain

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All nucleic 17

cDNA 17

Microarray probesets 8

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MGI:1919839, MGI:5883595

Summaries

All 44

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 16
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hdgfl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73366	Chr7:81584379-81584398 (-)	-168 bp
Tssr73365	Chr7:81584318-81584340 (-)	-108 bp
Tssr73364	Chr7:81584064-81584211 (-)	83 bp
Tssr73363	Chr7:81584040-81584059 (-)	171 bp
Tssr73362	Chr7:81584025-81584036 (-)	190 bp
Tssr73361	Chr7:81583914-81583925 (-)	301 bp
Tssr73360	Chr7:81583562-81583620 (-)	630 bp
Tssr73359	Chr7:81553771-81553774 (-)	30,448 bp
Tssr73358	Chr7:81535083-81535099 (-)	49,130 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24