Zfp292 MGI Mouse Gene Detail - MGI:1353423

Symbol

Zfp292
Name

zinc finger protein 292
Synonyms

5730450D02Rik, 9430062L07Rik, Krox-10, mKIAA0530, Zfp-15, Zfp15, Zn-15, Zn-16

Feature Type

protein coding gene
IDs

MGI:1353423
NCBI Gene: 30046
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:34803113-34882960 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 16.86 cM, cytoband A5
Mapping Data

6 experiments

SNPs within 2kb

1954 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1353423	protein coding gene	Chr4:34803110-34882982 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028133	protein coding gene	Chr4:32399930-32483133 (-)
A/J	MGP_AJ_G0028091	protein coding gene	Chr4:31232177-31311832 (-)
AKR/J	MGP_AKRJ_G0028054	protein coding gene	Chr4:32054404-32137507 (-)
BALB/cJ	MGP_BALBcJ_G0028102	protein coding gene	Chr4:31499929-31580407 (-)
C3H/HeJ	MGP_C3HHeJ_G0027831	protein coding gene	Chr4:32360296-32448823 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028544	protein coding gene	Chr4:33632344-33718343 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025885	protein coding gene	Chr4:29327652-29406798 (-)
CAST/EiJ	MGP_CASTEiJ_G0027286	protein coding gene	Chr4:32163920-32248576 (-)
CBA/J	MGP_CBAJ_G0027803	protein coding gene	Chr4:34737527-34829473 (-)
DBA/2J	MGP_DBA2J_G0027947	protein coding gene	Chr4:31203083-31284037 (-)
FVB/NJ	MGP_FVBNJ_G0027913	protein coding gene	Chr4:30619579-30701455 (-)
LP/J	MGP_LPJ_G0028055	protein coding gene	Chr4:32485376-32588904 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027946	protein coding gene	Chr4:37324623-37409140 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028603	protein coding gene	Chr4:32072302-32156855 (-)
PWK/PhJ	MGP_PWKPhJ_G0027005	protein coding gene	Chr4:31232416-31313475 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026834	protein coding gene	Chr4:31941673-32020546 (-)
WSB/EiJ	MGP_WSBEiJ_G0027362	protein coding gene	Chr4:32071413-32151152 (-)

Human Ortholog

ZNF292, zinc finger protein 292

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF292, zinc finger protein 292
Synonyms

bA393I2.3, MRD63, MRD64, Nbla00365, ZFP292, Zn-15, ZN-16
Links

HGNC:18410

NCBI Gene ID: 23036

neXtProt AC: NX_O60281

UniProt: O60281
Chr Location

6q14.3; chr6:87151803-87265943 (+) GRCh38

MGI Vertebrate Homology

Zfp292 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ZNF292
Gene Tree

Zfp292

Diseases

1 with human ZNF292 associations

				Human Disease	Mouse Models
				autosomal dominant intellectual developmental disorder IDs autosomal dominant intellectual developmental disorder DOID:0060307 OMIM:PS156200 ORDO:178469

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

75
Chemically and radiation induced

1
Endonuclease-mediated

4
Gene trapped

67
Targeted

3
Genomic Mutations

1 involving Zfp292
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

153 strains or lines available

Mice homozygous for a null allele exhibit decreased ILC3 with increased susceptibility to C. rodentium infection.

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

744
Tissues

38
cDNA Data

125
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase znf292

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All Sequences

62
RefSeq

13
UniProt

4
CCDS

CCDS51138.1

Ensembl

ENSMUSG00000039967 (Evidence)
NCBI Gene

30046

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039967	Ensembl Gene Model \| MGI Sequence Detail	79848	C57BL/6J	± kb
transcript	ENSMUST00000047950	Ensembl \| MGI Sequence Detail	9986	Not Applicable
polypeptide	ENSMUSP00000037233	Ensembl \| MGI Sequence Detail	2698	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017811 zinc finger protein 292

(term hierarchy)
InterPro Domains

IPR052251 Glycosyl Hydrolase and Zinc Finger Regulators

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

Q9Z2U2 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 128

Genomic 1

cDNA 126

Primer pair 1

Microarray probesets 9

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MGD-MRK-11609, MGD-MRK-15858, MGD-MRK-15914, MGI:1917828, MGI:1924556, MGI:2140283, MGI:99162

Summaries

All 56

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 14
Earliest

J:9172 Chavrier P, et al., Characterization of a mouse multigene family that encodes zinc finger structures. Mol Cell Biol. 1988 Mar;8(3):1319-26
Latest

J:337931 Li L, et al., Mettl14-mediated m(6)A modification ensures the cell-cycle progression of late-born retinal progenitor cells. Cell Rep. 2023 Jun 1;42(6):112596

TSS for Zfp292:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr41208	Chr4:34882919-34882964 (-)	18 bp
Tssr41207	Chr4:34834862-34834865 (-)	48,096 bp
Tssr41206	Chr4:34806927-34806975 (-)	76,009 bp
Tssr41205	Chr4:34806307-34806348 (-)	76,632 bp
Tssr41204	Chr4:34805884-34805887 (-)	77,074 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24