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Baz1b Gene Detail
Summary
  • Symbol
    Baz1b
  • Name
    bromodomain adjacent to zinc finger domain, 1B
  • Synonyms
    Wbscr9, WSTF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353499
    NCBI Gene: 22385
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135216118-135274983 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 75.05 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1262 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353499
 protein coding gene Chr5:135214094-135274985 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030177
 protein coding gene Chr5:139690221-139753114 (+)
A/J MGP_AJ_G0030145
 protein coding gene Chr5:133715655-133777652 (+)
AKR/J MGP_AKRJ_G0030078
 protein coding gene Chr5:138060864-138124014 (+)
BALB/cJ MGP_BALBcJ_G0030155
 protein coding gene Chr5:135072621-135132768 (+)
C3H/HeJ MGP_C3HHeJ_G0029871
 protein coding gene Chr5:138622998-138684005 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030608
 protein coding gene Chr5:144919142-144981721 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027831
 protein coding gene Chr5:128013024-128078180 (+)
CAST/EiJ MGP_CASTEiJ_G0029280
 protein coding gene Chr5:138039392-138103953 (+)
CBA/J MGP_CBAJ_G0029841
 protein coding gene Chr5:150591565-150659166 (+)
DBA/2J MGP_DBA2J_G0029992
 protein coding gene Chr5:133616610-133675610 (+)
FVB/NJ MGP_FVBNJ_G0029947
 protein coding gene Chr5:132751306-132809546 (+)
LP/J MGP_LPJ_G0030080
 protein coding gene Chr5:140135770-140197638 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029979
 protein coding gene Chr5:153602472-153665609 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030648
 protein coding gene Chr5:137807932-137870461 (+)
PWK/PhJ MGP_PWKPhJ_G0028995
 protein coding gene Chr5:132658913-132719975 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028830
 protein coding gene Chr5:135372517-135437979 (+)
WSB/EiJ MGP_WSBEiJ_G0029354
 protein coding gene Chr5:138558280-138617495 (+)



Homology
more
  • Human Ortholog
    BAZ1B, bromodomain adjacent to zinc finger domain 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BAZ1B, bromodomain adjacent to zinc finger domain 1B
  • Synonyms
    WBSCR10, WBSCR9, WSTF
  • Links
    NCBI Gene ID: 9031
    neXtProt AC: NX_Q9UIG0
    UniProt: Q9UIG0

  • Chr Location
    7q11.23; chr7:73440406-73522293 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Baz1b mouse models

Human Disease Mouse Models
      
IDs
 View 6 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 3 alleles in 3 genetic backgrounds
    3 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal lethality by P2, small size at birth, impaired double strand DNA repair, and heart defects. Mice heterozygous for a null allele exhibit hypercalcemia and heart defects. Mice homozygous for an ENU mutation exhibit craniofacial and skeletal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    935
  • Tissues
    201
  • cDNA Data
    141
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002748 Ensembl Gene Model | MGI Sequence Detail 58866 C57BL/6J ±  kb
    transcript ENSMUST00000002825 Ensembl | MGI Sequence Detail 6492 Not Applicable  
    polypeptide ENSMUSP00000002825 Ensembl | MGI Sequence Detail 1479 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 152
      Genomic 5
      cDNA 142
      Primer pair 5

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1329032, MGI:2141344
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 16
      Diseases 4
      Gene Ontology 13
      Phenotypes 30
    • Earliest
      J:51602 Peoples RJ, et al., Identification of the WBSCR9 gene, encoding a novel transcriptional regulator, in the Williams-Beuren syndrome deletion at 7q11.23. Cytogenet Cell Genet. 1998;82(3-4):238-46
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory