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Foxe1 Gene Detail
Summary
  • Symbol
    Foxe1
  • Name
    forkhead box E1
  • Synonyms
    thyroid transcription factor 2, Titf2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353500
    NCBI Gene: 110805
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:46343644-46345774 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 24.68 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353500
 protein coding gene Chr4:46343609-46346412 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028255
 protein coding gene Chr4:44641964-44644768 (+)
A/J MGP_AJ_G0028214
 protein coding gene Chr4:43016493-43019297 (+)
AKR/J MGP_AKRJ_G0028164
 protein coding gene Chr4:44066014-44068817 (+)
BALB/cJ MGP_BALBcJ_G0028234
 protein coding gene Chr4:43112564-43115350 (+)
C3H/HeJ MGP_C3HHeJ_G0027955
 protein coding gene Chr4:44669921-44672725 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028675
 protein coding gene Chr4:46290929-46293732 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025984
 protein coding gene Chr4:40395201-40398036 (+)
CAST/EiJ MGP_CASTEiJ_G0027394
 protein coding gene Chr4:44218637-44221440 (+)
CBA/J MGP_CBAJ_G0027921
 protein coding gene Chr4:47761410-47764214 (+)
DBA/2J MGP_DBA2J_G0028071
 protein coding gene Chr4:42907646-42910450 (+)
FVB/NJ MGP_FVBNJ_G0028038
 protein coding gene Chr4:42155836-42158639 (+)
LP/J MGP_LPJ_G0028170
 protein coding gene Chr4:44698562-44701366 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028062
 protein coding gene Chr4:50853556-50856359 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028710
 protein coding gene Chr4:44281692-44284495 (+)
PWK/PhJ MGP_PWKPhJ_G0027119
 protein coding gene Chr4:43003056-43005857 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026947
 protein coding gene Chr4:43785338-43788153 (+)
WSB/EiJ MGP_WSBEiJ_G0027472
 protein coding gene Chr4:44186117-44188921 (+)



Homology
more
  • Human Ortholog
    FOXE1, forkhead box E1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXE1, forkhead box E1
  • Synonyms
    BAMLAZ, FKHL15, FOXE2, HFKH4, HFKL5, NMTC4, TITF2, TTF-2, TTF2
  • Links
    NCBI Gene ID: 2304
    neXtProt AC: NX_O00358
    UniProt: O00358

  • Chr Location
    9q22.33; chr9:97853226-97856717 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Foxe1 mouse models; 2 with human FOXE1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die within 48 hours of birth exhibiting cleft palate and a sublingual or absent thyroid gland due to thyroid dysgenesis at the stage of endodermal bud migration. Mutant skin grafts display thin, sparse and kinky pelage hairs due to defects in late hair follicle morphogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    836
  • Tissues
    51
  • cDNA Data
    7
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110805 NCBI Gene Model | MGI Sequence Detail 2131 C57BL/6J ±  kb
    transcript NM_183298 RefSeq | MGI Sequence Detail 2131 ZRU/MplStud  
    polypeptide Q8R2I0 UniProt | EBI | MGI Sequence Detail 371 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 9
      Primer pair 4
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:894329
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 33
      Diseases 2
      Gene Ontology 10
      Phenotypes 9
    • Earliest
      J:41061 Zannini M, et al., TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. EMBO J. 1997 Jun 2;16(11):3185-97
    • Latest
      J:352715 Kang HS, et al., GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression. Cell Mol Life Sci. 2024 Jan 28;81(1):65
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory