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Foxe3 Gene Detail
Summary
  • Symbol
    Foxe3
  • Name
    forkhead box E3
  • Synonyms
    FREAC8, rct
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353569
    NCBI Gene: 30923
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:114782344-114783210 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 52.73 cM, cytoband C7
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353569
 protein coding gene Chr4:114781640-114783264 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028591
 protein coding gene Chr4:115684386-115685252 (-)
A/J MGP_AJ_G0028553
 protein coding gene Chr4:111268939-111269805 (-)
AKR/J MGP_AKRJ_G0028501
 protein coding gene Chr4:113572938-113573804 (-)
BALB/cJ MGP_BALBcJ_G0028573
 protein coding gene Chr4:111910699-111911565 (-)
C3H/HeJ MGP_C3HHeJ_G0028287
 protein coding gene Chr4:115187737-115188603 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029017
 protein coding gene Chr4:120160574-120161440 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026301
 protein coding gene Chr4:105369285-105370151 (-)
CAST/EiJ MGP_CASTEiJ_G0027724
 protein coding gene Chr4:112606873-112607739 (-)
CBA/J MGP_CBAJ_G0028255
 protein coding gene Chr4:123265473-123266339 (-)
DBA/2J MGP_DBA2J_G0028404
 protein coding gene Chr4:111916651-111917523 (-)
FVB/NJ MGP_FVBNJ_G0028372
 protein coding gene Chr4:110386846-110387712 (-)
LP/J MGP_LPJ_G0028505
 protein coding gene Chr4:115888099-115888965 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028397
 protein coding gene Chr4:128417428-128418294 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029053
 protein coding gene Chr4:114819299-114820165 (-)
PWK/PhJ MGP_PWKPhJ_G0027449
 protein coding gene Chr4:108702615-108703481 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027273
 protein coding gene Chr4:111206857-111207720 (-)
WSB/EiJ MGP_WSBEiJ_G0027802
 protein coding gene Chr4:114603477-114604343 (-)



Homology
more
  • Human Ortholog
    FOXE3, forkhead box E3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXE3, forkhead box E3
  • Synonyms
    AAT11, ASGD2, CATC3, CTRCT34, FKHL12, FREAC8
  • Links
    NCBI Gene ID: 2301
    neXtProt AC: NX_Q13461
    UniProt: Q13461

  • Chr Location
    1p33; chr1:47416285-47418052 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Foxe3 mouse models; 4 with human FOXE3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 4 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    2 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous or null mutation display microphthalmia, fusion of the lens and cornea, and other corneal and lens abnormalities. Null mice have reduced smooth muscle cell density in the ascending aorta and show aortic remodeling and rupture of the aorta after TAC.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    904
  • Tissues
    132
  • cDNA Data
    5
  • Literature Summary
    62
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044518 Ensembl Gene Model | MGI Sequence Detail 867 C57BL/6J ±  kb
    transcript ENSMUST00000050940 Ensembl | MGI Sequence Detail 867 Not Applicable  
    polypeptide ENSMUSP00000050445 Ensembl | MGI Sequence Detail 288 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 5
      Primer pair 3
      Other 5

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-9263, MGI:1890502, MGI:95261
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 62
      Diseases 2
      Gene Ontology 12
      Phenotypes 27
    • Earliest
      J:6131 Sanyal S, et al., Dysgenetic lens (dyl)--a new gene in the mouse. Invest Ophthalmol Vis Sci. 1979 Jun;18(6):642-5
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory