Pik3cg MGI Mouse Gene Detail - MGI:1353576 - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

Symbol

Pik3cg
Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Synonyms

5830428L06Rik, p110gamma, PI(3)Kgamma, PI3K^gamma, PI3Kgamma

Feature Type

protein coding gene
IDs

MGI:1353576
NCBI Gene: 30955
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr12:32223472-32258658 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 13.74 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

1001 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1353576	protein coding gene	Chr12:32223128-32258675 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019669	protein coding gene	Chr12:30160177-30209487 (-)
A/J	MGP_AJ_G0019636	protein coding gene	Chr12:29302316-29339445 (-)
AKR/J	MGP_AKRJ_G0019607	protein coding gene	Chr12:30234805-30272100 (-)
BALB/cJ	MGP_BALBcJ_G0019613	protein coding gene	Chr12:29527295-29563013 (-)
C3H/HeJ	MGP_C3HHeJ_G0019417	protein coding gene	Chr12:30114026-30152767 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020060	protein coding gene	Chr12:31108090-31144088 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017685	protein coding gene	Chr12:28589894-28627196 (-)
CAST/EiJ	MGP_CASTEiJ_G0018972	protein coding gene	Chr12:25126496-25164883 (-)
CBA/J	MGP_CBAJ_G0019389	protein coding gene	Chr12:32110370-32148346 (-)
DBA/2J	MGP_DBA2J_G0019502	protein coding gene	Chr12:29128297-29162909 (-)
FVB/NJ	MGP_FVBNJ_G0019493	protein coding gene	Chr12:28916392-28952698 (-)
LP/J	MGP_LPJ_G0019572	protein coding gene	Chr12:30259013-30298605 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019528	protein coding gene	Chr12:31745843-31783358 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020100	protein coding gene	Chr12:29761972-29797713 (-)
PWK/PhJ	MGP_PWKPhJ_G0018739	protein coding gene	Chr12:23879977-23918282 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018527	protein coding gene	Chr12:24356607-24397681 (-)
WSB/EiJ	MGP_WSBEiJ_G0019022	protein coding gene	Chr12:29999537-30036430 (-)

Human Ortholog

PIK3CG, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PIK3CG, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Synonyms

IMD97, p110gamma, p120-PI3K, PI3CG, PI3K, PI3Kgamma, PIK3
Links

HGNC:8978

NCBI Gene ID: 5294

neXtProt AC: NX_P48736

UniProt: P48736
Chr Location

7q22.3; chr7:106865278-106908980 (+) GRCh38

MGI Vertebrate Homology

Pik3cg stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PIK3CG
Gene Tree

Pik3cg

Diseases

3 with human PIK3CG associations

				Human Disease	Mouse Models
				autistic disorder IDs autistic disorder DOID:12849 EFO:0003758 ICD10CM:F84.0 ICD9CM:299.0 MESH:D001321 NCI:C97161 OMIM:209850 ORDO:106 UMLS_CUI:C0004352
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051
				swine influenza IDs swine influenza DOID:0050211

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

51 phenotypes from 7 alleles in 8 genetic backgrounds
27 phenotypes from multigenic genotypes
1 images
195 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

3
Targeted

11
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display defects in thymocyte development, T cell activation, and neutrophil migration.

less

All GO Annotations

95
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

95
cDNA Data

13
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pik3cg

less

All Sequences

82
RefSeq

14
UniProt

8
CCDS

CCDS25870.1

Ensembl

ENSMUSG00000020573 (Evidence)
NCBI Gene

30955

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020573	Ensembl Gene Model \| MGI Sequence Detail	35187	C57BL/6J	± kb
transcript	ENSMUST00000156904	Ensembl \| MGI Sequence Detail	4805	Not Applicable
polypeptide	ENSMUSP00000123539	Ensembl \| MGI Sequence Detail	1102	Not Applicable

less

UniProt

8 Sequences
Protein Ontology

PR:000012722 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

(term hierarchy)
EC

2.7.1.137, 2.7.1.153, 2.7.1.154, 2.7.11.1
InterPro Domains

IPR016024 Armadillo-type fold

IPR035892 C2 domain superfamily

IPR002420 C2 phosphatidylinositol 3-kinase-type domain

IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain

IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

IPR018936 Phosphatidylinositol 3/4-kinase, conserved site

IPR003113 Phosphatidylinositol 3-kinase, adaptor-binding domain

IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain

IPR015433 Phosphatidylinositol kinase

IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain

IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamily

IPR045580 PIK3 catalytic subunit gamma, adaptor-binding domain

IPR011009 Protein kinase-like domain superfamily

IPR029071 Ubiquitin-like domain superfamily

less

All nucleic 16

Genomic 1

cDNA 14

Primer pair 1

Microarray probesets 5

less

MGI:1923289

Summaries

All 275

Developmental Gene Expression 4

Gene Ontology 17

Phenotypes 195
Earliest

J:68953 Klesse LJ, et al., p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons. J Neurosci. 1998 Dec 15;18(24):10420-8
Latest

J:351126 Shepard RM, et al., PI3Kgamma inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections. Sci Transl Med. 2024 Jul 3;16(754):eadi6887

TSS for Pik3cg:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116090	Chr12:32258608-32258682 (-)	13 bp
Tssr116089	Chr12:32258558-32258571 (-)	93 bp
Tssr116088	Chr12:32258526-32258541 (-)	124 bp
Tssr116087	Chr12:32258502-32258513 (-)	150 bp
Tssr116086	Chr12:32258331-32258399 (-)	293 bp
Tssr116085	Chr12:32258200-32258229 (-)	443 bp
Tssr116084	Chr12:32235198-32235207 (-)	23,455 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24