Ddx25 MGI Mouse Gene Detail - MGI:1353582

Symbol

Ddx25
Name

DEAD box helicase 25
Synonyms

DEAD (Asp-Glu-Ala-Asp) box polypeptide 25, GRTH

Feature Type

protein coding gene
IDs

MGI:1353582
NCBI Gene: 30959
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr9:35453144-35469766 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 20.31 cM, cytoband A3-A5
Mapping Data

3 experiments

SNPs within 2kb

537 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1353582	protein coding gene	Chr9:35447943-35469824 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034536	protein coding gene	Chr9:33351103-33373938 (-)
A/J	MGP_AJ_G0034514	protein coding gene	Chr9:32482648-32504523 (-)
AKR/J	MGP_AKRJ_G0034440	protein coding gene	Chr9:33217183-33239071 (-)
BALB/cJ	MGP_BALBcJ_G0034505	protein coding gene	Chr9:32400957-32422852 (-)
C3H/HeJ	MGP_C3HHeJ_G0034217	protein coding gene	Chr9:33550471-33572359 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035026	protein coding gene	Chr9:34466089-34487982 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031956	protein coding gene	Chr9:31169942-31192130 (-)
CAST/EiJ	MGP_CASTEiJ_G0033540	protein coding gene	Chr9:33456596-33478348 (-)
CBA/J	MGP_CBAJ_G0034191	protein coding gene	Chr9:35618151-35644484 (-)
DBA/2J	MGP_DBA2J_G0034348	protein coding gene	Chr9:32466270-32488169 (-)
FVB/NJ	MGP_FVBNJ_G0034291	protein coding gene	Chr9:31883479-31905360 (-)
LP/J	MGP_LPJ_G0034434	protein coding gene	Chr9:33594614-33616385 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034335	protein coding gene	Chr9:37186474-37208367 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035046	protein coding gene	Chr9:33164423-33186182 (-)
PWK/PhJ	MGP_PWKPhJ_G0033245	protein coding gene	Chr9:32451261-32473284 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033080	protein coding gene	Chr9:33313735-33336335 (-)
WSB/EiJ	MGP_WSBEiJ_G0033655	protein coding gene	Chr9:32937872-32959762 (-)

Human Ortholog

DDX25, DEAD-box helicase 25

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDX25, DEAD-box helicase 25
Synonyms

GRTH
Links

HGNC:18698

NCBI Gene ID: 29118

neXtProt AC: NX_Q9UHL0

UniProt: Q9UHL0
Chr Location

11q24.2; chr11:125903328-125943702 (+) GRCh38

MGI Vertebrate Homology

Ddx25 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DDX25
Gene Tree

Ddx25

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display male infertility, arrest of spermatogenesis at step 8, abnormal Leydig cells, and increased germ cell apoptosis in males.

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All GO Annotations

27
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

3
cDNA Data

46
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddx25

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS52753.1

Ensembl

ENSMUSG00000032101 (Evidence)
NCBI Gene

30959

			Length	Strain/Species	Flank
genomic	30959	NCBI Gene Model \| MGI Sequence Detail	16623	C57BL/6J	± kb
transcript	NM_013932	RefSeq \| MGI Sequence Detail	1675	C57BL/6
polypeptide	Q9QY15	UniProt \| EBI \| MGI Sequence Detail	484	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006361 ATP-dependent RNA helicase DDX25

(term hierarchy)
EC

3.6.4.13
InterPro Domains

IPR011545 DEAD/DEAH box helicase domain

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR014014 RNA helicase, DEAD-box type, Q motif

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All nucleic 46

cDNA 46

Microarray probesets 4

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MGI:2143278

Summaries

All 47

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 17
Earliest

J:59130 Tang PZ, et al., A novel gonadotropin-regulated testicular RNA helicase. A new member of the dead-box family. J Biol Chem. 1999 Dec 31;274(53):37932-40
Latest

J:337868 Anbazhagan R, et al., miRNA Expression Profiles of Mouse Round Spermatids in GRTH/DDX25-Mediated Spermiogenesis: mRNA-miRNA Network Analysis. Cells. 2023 Feb 27;12(5)

TSS for Ddx25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr88744	Chr9:35469818-35469844 (-)	-65 bp
Tssr88743	Chr9:35469801-35469814 (-)	-42 bp
Tssr88742	Chr9:35469755-35469772 (-)	2 bp
Tssr88741	Chr9:35469693-35469747 (-)	46 bp
Tssr88740	Chr9:35458116-35458138 (-)	11,639 bp
Tssr88739	Chr9:35455997-35456001 (-)	13,767 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24