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Hacd1 Gene Detail
Summary
  • Symbol
    Hacd1
  • Name
    3-hydroxyacyl-CoA dehydratase 1
  • Synonyms
    Ptpla
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353592
    NCBI Gene: 30963
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:14031642-14060846 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 10.30 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    774 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353592
 protein coding gene Chr2:13855093-14060847 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025359
 protein coding gene Chr2:11365522-11562844 (-)
A/J MGP_AJ_G0025336
 protein coding gene Chr2:10934631-11133538 (-)
AKR/J MGP_AKRJ_G0025305
 protein coding gene Chr2:11249122-11458599 (-)
BALB/cJ MGP_BALBcJ_G0025332
 protein coding gene Chr2:10921535-11126469 (-)
C3H/HeJ MGP_C3HHeJ_G0025092
 protein coding gene Chr2:11198343-11414336 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025774
 protein coding gene Chr2:11850489-11877349 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023189
 protein coding gene Chr2:10532573-10697669 (-)
CAST/EiJ MGP_CASTEiJ_G0024555
 protein coding gene Chr2:11163779-11393006 (-)
CBA/J MGP_CBAJ_G0025071
 protein coding gene Chr2:12148791-12386635 (-)
DBA/2J MGP_DBA2J_G0025203
 protein coding gene Chr2:10825603-11027253 (-)
FVB/NJ MGP_FVBNJ_G0025165
 protein coding gene Chr2:10727230-10925686 (-)
LP/J MGP_LPJ_G0025289
 protein coding gene Chr2:11453757-11483604 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025197
 protein coding gene Chr2:12025351-12244465 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025832
 protein coding gene Chr2:11162372-11362858 (-)
PWK/PhJ MGP_PWKPhJ_G0024306
 protein coding gene Chr2:10709693-10913333 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024106
 protein coding gene Chr2:11136569-11427497 (-)
WSB/EiJ MGP_WSBEiJ_G0024625
 protein coding gene Chr2:11279657-11491580 (-)



Homology
more
  • Human Ortholog
    HACD1, 3-hydroxyacyl-CoA dehydratase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HACD1, 3-hydroxyacyl-CoA dehydratase 1
  • Synonyms
    CAP, CMYO11, CMYP11, MYONP, PTPLA
  • Links
    NCBI Gene ID: 9200
    neXtProt AC: NX_B0YJ81
    UniProt: B0YJ81

  • Chr Location
    10p12.33; chr10:17589032-17617374 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HACD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout leads to decreased body size and weight and reduced skeletal muscle weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    792
  • Tissues
    50
  • cDNA Data
    45
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30963 NCBI Gene Model | MGI Sequence Detail 29205 C57BL/6J ±  kb
    transcript NM_013935 RefSeq | MGI Sequence Detail 1015 C57BL/6  
    polypeptide Q9QY80 UniProt | EBI | MGI Sequence Detail 281 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 45
      Primer pair 4

      Microarray probesets 4
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:60250 Uwanogho DA, et al., Molecular cloning, chromosomal mapping, and developmental expression of a novel protein tyrosine phosphatase-like gene. Genomics. 1999 Dec 15;62(3):406-16
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory